The combined use of amantadine and l-dopa/carbidopa in the treatment of chronic brain injury.

Abstract:

:The frontal lobes are particularly vulnerable to injury during trauma. The syndrome commonly attributed to frontal lobe dysfunction includes problems with impulsivity, perseveration, disinhibition, amotivation, attention, planning, and problem solving. These symptoms can respond to certain pharmacologic interventions, such as the dopaminergic agents. The case of a 50-year-old woman who showed persistent frontal dysfunction 5 years post-injury is described. After treatment with amantadine alone, she showed decreased impulsivity and perseveration and improved executive function. Further positive response was obtained with the addition of l-dopa/carbidopa, with additional improvements in constructional praxis, divided auditory attention, and cognitive flexibility. Her improved functioning following treatment demonstrates the potential for increasing effectiveness through a combination of dopaminergic agents. No side effects were observed, and the patient maintained gains at follow-up. The rationale for using dopaminergic agents alone and in combination is discussed.

journal_name

Brain Inj

journal_title

Brain injury

authors

Kraus MF,Maki P

doi

10.1080/026990597123430

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

455-60

issue

6

eissn

0269-9052

issn

1362-301X

journal_volume

11

pub_type

杂志文章
  • A QEEG index of level of functional dependence for people sustaining acquired brain injury: the Seville Independence Index (SINDI).

    abstract:PRIMARY OBJECTIVE:To find an easy-to-use, valid and reliable tool for evaluating the level of functional dependence of an individual with brain damage who seeks a diagnosis of his/her functional dependence in daily activities. METHODS:Eighty-one patients with acquired brain injury (ABI) in post-acute phase, 40 traumat...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701824143

    authors: Leon-Carrion J,Martin-Rodriguez JF,Damas-Lopez J,Martin JM,Dominguez-Morales Mdel R

    更新日期:2008-01-01 00:00:00

  • False positive diagnosis of malingering due to the use of multiple effort tests.

    abstract:OBJECTIVE:Effort indicators are used to determine if neuropsychological test results are valid measures of a patient's cognitive abilities. The use of multiple effort measures is often advocated, but the false positive rate for multiple indicators depends on the number of measures used and the correlation among indicat...

    journal_title:Brain injury

    pub_type: 杂志文章,meta分析,评审

    doi:10.3109/02699052.2013.793400

    authors: Berthelson L,Mulchan SS,Odland AP,Miller LJ,Mittenberg W

    更新日期:2013-01-01 00:00:00

  • Is high PEEP ventilation strategy safe for acute respiratory distress syndrome after severe traumatic brain injury?

    abstract:PRIMARY OBJECTIVE:To investigate the safety and efficacy of high positive end-expiratory pressure (PEEP) ventilation strategy for acute respiratory distress syndrome (ARDS) after traumatic brain injury. RESEARCH DESIGN:A case report and discussion based on literature review. METHODS AND PROCEDURES:This article report...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2012.660514

    authors: Lou M,Xue F,Chen L,Xue Y,Wang K

    更新日期:2012-01-01 00:00:00

  • The effects of motivating interventions on rehabilitation outcomes in children and youth with acquired brain injuries: a systematic review.

    abstract:PRIMARY OBJECTIVE:To systematically review the evidence of the effects of motivating rehabilitation interventions on outcomes in children with acquired brain injury (ABI). METHODS:A literature search of six databases was conducted to identify intervention studies published until July 2013. The American Academy for Cer...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2014.890747

    authors: Tatla SK,Sauve K,Jarus T,Virji-Babul N,Holsti L

    更新日期:2014-01-01 00:00:00

  • Neuroendocrine dysfunction in acute phase of moderate-to-severe traumatic brain injury: a prospective study.

    abstract:OBJECTIVES:Most of the retrospective studies have demonstrated that traumatic brain injury mediated hypopituitarism could be more frequent than previously known. Therefore, this study has prospectively investigated pituitary function and their correlation with severity, pressure effect and Glasgow Outcome Scale in the ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.955882

    authors: Prasanna KL,Mittal RS,Gandhi A

    更新日期:2015-01-01 00:00:00

  • Attentional deficits in patients with closed head injury: a further study to the discriminative validity of the test of everyday attention.

    abstract::This study aimed to explore the attentional performance of patients with closed head injury (CHI) and to examine the discriminative validity of the Test of Everyday Attention (TEA) in this clinical population. A sample of 21 patients with CHI was recruited for this study. Another sample of matched controls was also re...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990500120709

    authors: Chan RC

    更新日期:2000-03-01 00:00:00

  • Investigating ioflupane I123 injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.

    abstract:OBJECTIVE:To determine whether there were differences in clinical outcomes for ioflupane I123 injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI). METHODS:We performed a case-control study among ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1388443

    authors: Reams N,Anderson J,Perlman R,Li W,Walters S,Tideman S,Wang C,Simon K,Frigerio R,Maraganore DM

    更新日期:2018-01-01 00:00:00

  • The utility of the Convergence Insufficiency Symptom Survey (CISS) post-concussion.

    abstract::Background: The Convergence Insufficiency Symptom Survey (CISS) is being utilized as an assessment measure following concussion despite minimal research. This study explored the sensitivity and specificity of the CISS in identifying receded near point of convergence (NPC) post-concussion. Methods: Prospective study of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1658131

    authors: Trbovich AM,Sherry NK,Henley J,Emami K,Kontos AP

    更新日期:2019-01-01 00:00:00

  • Neurologically-related sequelae associated with mild traumatic brain injury.

    abstract:OBJECTIVE:Mild traumatic brain injury (mTBI) accounts for more than 75% of traumatic brain injuries every year. This study examines the temporal association between non-blast mTBI and the onset of neurologic sequelae to illuminate risks of post-concussive syndrome, epilepsy and chronic pain. METHODS:A large historical...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.989904

    authors: Webb TS,Whitehead CR,Wells TS,Gore RK,Otte CN

    更新日期:2015-01-01 00:00:00

  • Baicalin protects PC-12 cells from oxidative stress induced by hydrogen peroxide via anti-apoptotic effects.

    abstract:PRIMARY OBJECTIVE:To examine the neuroprotection of baicalin, a flavonoid compound derived from the dried root of Scutellaria baicalensis Georgi, on neurons. RESEARCH DESIGN:A rat PC12 cell line was used to study the neuroprotection and possible mechanisms of baicalin on H₂O₂-induced neuron damage. METHODS:Three anti...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2013.860469

    authors: Zheng WX,Wang F,Cao XL,Pan HY,Liu XY,Hu XM,Sun YY

    更新日期:2014-01-01 00:00:00

  • Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury.

    abstract:UNLABELLED:Abstract Introduction: Traumatic brain injury is a main cause of disability and death in developed countries, above all among children and adolescents. The intrinsic inability of the central nervous system to efficiently repair traumatic injuries renders transplantation of bone marrow-derived cells (BMDC) a ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.973448

    authors: Paradells S,Zipancic I,Martínez-Losa MM,García Esparza MÁ,Bosch-Morell F,Alvarez-Dolado M,Soria JM

    更新日期:2015-01-01 00:00:00

  • Dynamics of clinical recovery during the early phase of rehabilitation in patients with severe traumatic and non-traumatic brain injury.

    abstract:PURPOSE:Our aim was to describe the changes in the functional outcome at the early phase of rehabilitation following severe brain injury and to identify the factors associated with faster recovery. METHODS:This retrospective analysis included 182 patients who were transferred from the intensive care unit (ICU) to a po...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1376759

    authors: Oujamaa L,Francony G,Boucheix P,Schilte C,Bouzat P,Perennou D,Payen JF

    更新日期:2017-01-01 00:00:00

  • Casual conversations between individuals with traumatic brain injury and their friends.

    abstract:PRIMARY OBJECTIVE:To investigate casual conversations with friends following severe traumatic brain injury (TBI). METHODS:Nine participants with severe TBI were matched by age, gender and education to nine control participants. Each participant also invited a friend to partake in the study. Participants were recorded ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2011.648711

    authors: Bogart E,Togher L,Power E,Docking K

    更新日期:2012-01-01 00:00:00

  • Long-term multi-dimensional outcome following isolated traumatic brain injuries and traumatic brain injuries associated with multiple trauma.

    abstract::We retrospectively investigated long-term, multi-dimensional quality-of-life outcomes in 68 male patients who suffered pure head injuries and 63 male head-injured patients with associated multiple trauma. Results indicated that patients sustaining associated multiple trauma were significantly younger and more deeply c...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059009026191

    authors: Moore AD,Stambrook M,Peters LC,Cardoso ER,Kassum DA

    更新日期:1990-10-01 00:00:00

  • Sinemet and brain injury: functional versus statistical change and suggestions for future research designs.

    abstract::During the past decade the usage of dopaminergic agonists for the brain-injured population has become a more common treatment option during both the acute and subacute phases of recovery. We attempted to use Sinemet to address the functional limitations of a 74-year-old woman who was 7 months status post-traumatic bra...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008208

    authors: Wolf AP,Gleckman AD

    更新日期:1995-07-01 00:00:00

  • Mortality among older adults after a traumatic brain injury: a meta-analysis.

    abstract:PRIMARY OBJECTIVE:To examine mortality rates among older adults (≥60 years) post-traumatic brain injury (TBI). RESEARCH DESIGN:Systematic review and meta-analysis. METHODS AND PROCEDURES:Using multiple databases, a literature search was conducted for articles on mortality after TBI published up to July 2011. Informat...

    journal_title:Brain injury

    pub_type: 杂志文章,meta分析,评审

    doi:10.3109/02699052.2012.700086

    authors: McIntyre A,Mehta S,Aubut J,Dijkers M,Teasell RW

    更新日期:2013-01-01 00:00:00

  • Diagnostic criteria and differential diagnosis of mild traumatic brain injury.

    abstract::Brain injury is classified clinically as severe, moderate or mild brain injury characteristics, including admission Glasgow coma score, duration of unconsciousness and post-traumatic amnesia and any focal neurological findings. Most traumatic brain injuries are classified as mild traumatic brain injury (MTBI). Headach...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/026990501458335

    authors: De Kruijk JR,Twijnstra A,Leffers P

    更新日期:2001-02-01 00:00:00

  • Biochemical and physiological parameters of recovery in acute severe head injury: responses to multisensory stimulation.

    abstract::We investigated the efficacy of applying a programme of multisensory stimulation to patients with severe diffuse traumatic brain injury, during their admission to a tertiary neurosurgical intensive care unit. We attempted to determine the nature and extent of any physiological or biochemical changes occurring as a res...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/02699059309008176

    authors: Johnson DA,Roethig-Johnston K,Richards D

    更新日期:1993-11-01 00:00:00

  • The effects of cognitive teletherapy on reported everyday memory behaviours of persons with chronic traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:The purpose of this study was to evaluate the effects of an errorless training approach, Spaced Retrieval (SR) training delivered over the telephone, on the reported everyday memory problems of adults with chronic traumatic brain injury (TBI). RESEARCH DESIGN:The study was a randomized controlled cli...

    journal_title:Brain injury

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/02699050701727452

    authors: Bourgeois MS,Lenius K,Turkstra L,Camp C

    更新日期:2007-11-01 00:00:00

  • Reliability, validity and clinical usefulness of the BNI fatigue scale in mild traumatic brain injury.

    abstract:OBJECTIVES:The purpose of this study was to examine the reliability, validity and clinical usefulness of the Barrow Neurological Institute Fatigue Scale (BNI-FS) in patients with mild traumatic brain injuries (MTBI). METHODS AND PROCEDURE:Participants were 125 patients enrolled from the Emergency Department (ED) of Ta...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.660511

    authors: Wäljas M,Iverson GL,Hartikainen KM,Liimatainen S,Dastidar P,Soimakallio S,Jehkonen M,Ohman J

    更新日期:2012-01-01 00:00:00

  • Social competence and head injury: a new emphasis.

    abstract::In the push for quantifiable outcome-based rehabilitation programmes, sensitivity to the integrity and uniqueness of the individual has been moved to the background. This has been particularly noticeable in the area of social skills therapy for persons who have suffered a traumatic head injury. We review some of the p...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699059509004575

    authors: McGann W,Werven G

    更新日期:1995-01-01 00:00:00

  • Cognitive correlates of pragmatic language comprehension in adult traumatic brain injury: A systematic review and meta-analyses.

    abstract::Effective pragmatic comprehension of language is critical for successful communication and interaction, but this ability is routinely impaired following Traumatic Brain Injury (TBI) (1,2). Individual studies have investigated the cognitive domains associated with impaired pragmatic comprehension, but there remains lit...

    journal_title:Brain injury

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/02699052.2017.1341645

    authors: Rowley DA,Rogish M,Alexander T,Riggs KJ

    更新日期:2017-01-01 00:00:00

  • Mild traumatic brain injury in an insured population: subjective complaints and return to employment.

    abstract::The great majority of traumatic brain injury (TBI) is of mild severity, with Glasgow Coma Scores (GCS) of 13-15, post-traumatic amnesia of less than 48 hours and brief, if any, hospitalization. All mild TBI admissions to hospital were provided with education in the form of a brief interview and a brochure on minor hea...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059209029654

    authors: Englander J,Hall K,Stimpson T,Chaffin S

    更新日期:1992-03-01 00:00:00

  • Discourse recovery after severe traumatic brain injury: exploring the first year.

    abstract:OBJECTIVES:Although much is known about discourse impairment, little is known about discourse recovery after severe traumatic brain injury (TBI). This paper explores discourse recovery across the critical first year, controlling for pre-injury, injury and post-injury variables. DESIGN AND METHODS:An inception cohort c...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1539246

    authors: Elbourn E,Kenny B,Power E,Honan C,McDonald S,Tate R,Holland A,MacWhinney B,Togher L

    更新日期:2019-01-01 00:00:00

  • The course and impact of family optimism in the post-acute period after acquired brain injury.

    abstract:OBJECTIVE:To investigate the course and impact of family optimism in the post-acute stage of acquired brain injury. METHODS:At Time 1, 30 family relatives of in-patients in rehabilitation units and 30 relatives of patients recently discharged from such units completed questionnaires relating to their emotional health,...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1004754

    authors: Riley GA,Hough A,Meader LM,Brennan AJ

    更新日期:2015-01-01 00:00:00

  • Extent of intellectual, cognitive, and academic decline in adolescent traumatic brain injury.

    abstract::Pre-injury cognitive data are rarely available for review for individuals suffering from traumatic brain injury (TBI). Although pre-injury intelligence and academic scores may be available, particularly if an individual is learning-disabled (LD), data on specific cognitive abilities are unlikely to exist. We present n...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990596124322

    authors: Vieth AZ,Johnstone B,Dawson B

    更新日期:1996-06-01 00:00:00

  • Anoxic encephalopathy: a neurobehavioural study in rehabilitation.

    abstract::This study examined an operational conditioning paradigm designed to train procedural learning channels in a patient with anoxic encephalopathy. Prior to treatment the patient had been incontinent to bowel and bladder incontinent, minimally participant in daily activities and aggressive toward staff and residents for ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123115

    authors: Goldberg KB,Ellis DW

    更新日期:1997-10-01 00:00:00

  • Additive effects of sequential excitatory and inhibitory theta burst stimulation in improving cortical excitability following ischaemic stroke.

    abstract:PURPOSE:To study the effects of sequential excitatory and inhibitory theta burst stimulation (TBS) on cortical excitability in patients with subacute ischaemic stroke. METHODS:Fifteen patients with first-ever middle cerebral artery ischaemic stroke within last three months were subjected to intermittent TBS over the h...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1283536

    authors: Khan FR

    更新日期:2017-01-01 00:00:00

  • Sociodemographic, physical and psychosocial factors associated with depressive behaviour in family caregivers of stroke survivors in the acute care phase.

    abstract:PRIMARY OBJECTIVE:This study examined sociodemographic, physical and psychosocial characteristics of family caregivers of stroke survivors at risk for depression. RESEARCH DESIGN:A correlational study. METHODS AND PROCEDURES:Data were collected from 52 family caregivers and care recipients with ischemic stroke. Data ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050410001671766

    authors: Grant JS,Weaver M,Elliott TR,Bartolucci AR,Newman Giger J

    更新日期:2004-08-01 00:00:00

  • Effects of spatial working memory in balance during dual tasking in traumatic brain injury and healthy controls.

    abstract:OBJECTIVES:The aim of this research was to assess cognitive-motor interactions though dual tasks of working memory in patients with traumatic brain injury (TBI) and control subjects. Methods: Twenty patients with chronic TBI with good functional level and 19 matched healthy controls performed dual working memory tasks ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1792984

    authors: Useros Olmo AI,Periañez JA,Martínez-Pernía D,Miangolarra Page JC

    更新日期:2020-07-28 00:00:00