Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury.

Abstract:

UNLABELLED:Abstract Introduction: Traumatic brain injury is a main cause of disability and death in developed countries, above all among children and adolescents. The intrinsic inability of the central nervous system to efficiently repair traumatic injuries renders transplantation of bone marrow-derived cells (BMDC) a promising approach towards repair of brain lesions. On the other hand, many studies have reported the beneficial effect of Lipoic acid (LA), a potent antioxidant promoting cell survival, angiogenesis and neuroregeneration. METHODS:In this study, the cortex of adult mice was cryo-injured in order to mimic local traumatic brain injury. Vehicle or freshly prepared BMDC were grafted in the cerebral penumbra area 24 hours after unilateral local injury alone or combined with intra-peritoneal LA administration as a new regenerative strategy. RESULTS:Differences were found in the process of cell proliferation, angiogenesis and glial scar formation after local injury depending of the applied treatment, either LA or BMDC alone or in combination. CONCLUSION:The data presented here suggest that transplantation of BMDC is a good alternative and valid strategy to treat a focal brain injury when LA could not be prescribed due to its non-desired secondary effects.

journal_name

Brain Inj

journal_title

Brain injury

authors

Paradells S,Zipancic I,Martínez-Losa MM,García Esparza MÁ,Bosch-Morell F,Alvarez-Dolado M,Soria JM

doi

10.3109/02699052.2014.973448

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

380-95

issue

3

eissn

0269-9052

issn

1362-301X

journal_volume

29

pub_type

杂志文章
  • Impersistent execution of saccadic eye movements after traumatic brain injury.

    abstract::A dynamic scoring system was developed to quantitatively resolve the ability of a subject to persistently execute a repeated motor act. Saccadic eye movements in response to pseudo-random and periodic stimuli were examined in patients with traumatic brain injury (TBI) and in normal subjects. Results indicated signific...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008233

    authors: Glass I,Groswasser Z,Groswasser-Reider I

    更新日期:1995-11-01 00:00:00

  • The effects of normal ageing on neuropsychological functioning following traumatic brain injury.

    abstract::Increasing age is associated with greater absolute neuropsychological impairment (e.g. slower processing speed, diminished memory), although it is unclear if older individuals with traumatic brain injury (TBI) show greater relative impairment than younger individuals with TBI. The current study evaluated the effects o...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990598122331

    authors: Johnstone B,Childers MK,Hoerner J

    更新日期:1998-07-01 00:00:00

  • Self-awareness following a traumatic brain injury in childhood: a developmental perspective.

    abstract::Impaired self-awareness is a common consequence following a brain injury that affects engagement in rehabilitation and results in poor long term functional outcomes. Literature regarding self-awareness following a brain injury in childhood is lacking. The aim of this research study was to understand the self-awareness...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1566838

    authors: Wales L,Sidebotham P,Hawley C

    更新日期:2019-01-01 00:00:00

  • Consciousness recovery after various periods in vegetative state.

    abstract:BACKGROUND:Recent studies suggest that late recovery from vegetative state (VS) is more prevalent today than previously thought. This study examined the decline in the rate of recovery from VS with time after admission to rehabilitation, and established a new time frame, in which the odds of recovery from VS remain sub...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1800093

    authors: Aidinoff E,Elkayam K,Oximitny A,Groswasser Z,Gelernter I,Catz A

    更新日期:2020-07-28 00:00:00

  • Alcohol and drug use following traumatic brain injury: a prospective study.

    abstract:PRIMARY OBJECTIVES:To establish pre-morbid alcohol and drug use in persons with TBI, relative to controls, investigate how patterns of substance use change over time following TBI and identify factors associated with heavy post-injury substance use. METHODS AND PROCEDURES:The Alcohol Use Disorders Identification test ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701796960

    authors: Ponsford J,Whelan-Goodinson R,Bahar-Fuchs A

    更新日期:2007-12-01 00:00:00

  • Prognostic models for prediction of outcomes after traumatic brain injury based on patients admission characteristics.

    abstract:OBJECTIVE:To identify the best performing prognostic model using admission characteristics to predict mortality at 30 days and functioning outcome at 6-months post-admission in patients with moderate or severe brain injury. METHODS:Using a retrospective database (n = 1466 patients) of a tertiary trauma care centre, th...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1113568

    authors: Kamal VK,Agrawal D,Pandey RM

    更新日期:2016-01-01 00:00:00

  • Identification of rehabilitation problems after head injury.

    abstract::We have reported a large study of patients admitted to hospital following head injury in the city of Glasgow over one calendar year. This showed 1000 patients still to be disabled one year after their injury. In order to see whether the difficulties reported by these patients represented needs for rehabilitation servi...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050210154231

    authors: Roy CW,Thornhill S,Teasdale GM

    更新日期:2002-12-01 00:00:00

  • Neuroleptic malignant syndrome in a patient on long-term olanzapine treatment at a stable dose: Successful treatment with dantrolene.

    abstract:BACKGROUND:Neuroleptic malignant syndrome (NMS) is a rare life-threatening disorder resulting from treatment with neuroleptic agents and other drugs that act as dopamine antagonists. NMS most often occurs shortly after the initiation, dose increase or withdrawal of the offending agent, but can rarely occur after long-t...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.1002002

    authors: Kouparanis A,Bozikas A,Spilioti M,Tziomalos K

    更新日期:2015-01-01 00:00:00

  • Method of symptom assessment influences cognitive, affective and somatic post-concussion-like symptom base rates.

    abstract:PRIMARY OBJECTIVE:To investigate whether assessment method influences the type of post-concussion-like symptoms. METHODS AND PROCEDURES:Participants were 73 Australian undergraduate students (Mage = 24.14, SD = 8.84; 75.3% female) with no history of mild traumatic brain injury (mTBI). Participants reported symptoms ex...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.915988

    authors: Edmed SL,Sullivan KA

    更新日期:2014-01-01 00:00:00

  • Cognitive profile for Chinese patients with stroke.

    abstract:PRIMARY OBJECTIVE:This study aimed to investigate the usefulness of the Chinese version of Cognistat for patients with stroke in a Chinese community. METHODS AND PROCEDURES:A total of 53 patients and 34 normal elderly with age, gender and literacy level matched were tested with the Chinese translated version of Cognis...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050210131975

    authors: Chan CC,Lee TM,Fong KN,Lee C,Wong V

    更新日期:2002-10-01 00:00:00

  • Circadian rhythm of temperature in head injury.

    abstract::It has been shown in a previous study that head injured patients appear to have a circadian rhythm of their body functions. This needed to be confirmed using additional data, better collection methods and analysis. Additional goals were to develop a method of detrending of physiological time series in order to improve...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050010007515

    authors: Kropyvnytskyy I,Saunders F,Pols M,Zarowski C

    更新日期:2001-06-01 00:00:00

  • Neuropsychological functioning during the year following severe traumatic brain injury.

    abstract::The neuropsychological functioning of a group of 65 adults with severe traumatic brain injury was assessed at 6 months and 1 year post-injury. The cognitive domains assessed were pre-morbid intellectual level, current level of general intellectual functioning, simple and complex attention, verbal memory, executive fun...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050010005887

    authors: Kersel DA,Marsh NV,Havill JH,Sleigh JW

    更新日期:2001-04-01 00:00:00

  • What kind of consciousness is minimal?

    abstract:PRIMARY OBJECTIVE:A comparison between unitary and non-unitary views on minimal consciousness. RESEARCH DESIGN:First, unitary (all-or-none) and non-unitary (gradual or continuous) models of consciousness are defined as they have been developed in both philosophy and neurophysiology. Then, the implications of these ide...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2014.920523

    authors: Kotchoubey B,Vogel D,Lang S,Müller F

    更新日期:2014-01-01 00:00:00

  • Predictors of performance on three developmentally sensitive neuropsychological tests in children with and without traumatic brain injury.

    abstract:OBJECTIVE:To determine the effect of age and vocabulary as predictors of performance on neuropsychological tests in children with and without traumatic brain injury (TBI). SETTING AND PARTICIPANTS:In the first study, 213 school-age children were evaluated in their public school environment. In the second study, 65 chi...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802084902

    authors: Prigatano GP,Gray JA

    更新日期:2008-06-01 00:00:00

  • CT findings in persistent vegetative state following blunt traumatic brain injury.

    abstract::The use of linear measurements in the analysis of CT scans of TBI patients was found to contribute to the understanding of brain damage and were correlated with outcome in severe traumatic close brain injured patients. The purpose of the present study was to analyse the data obtained by the linear measurements on CT s...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597122936

    authors: Reider-Groswasser I,Costeff H,Sazbon L,Groswasser Z

    更新日期:1997-12-01 00:00:00

  • Pupillary responses to light in chronic non-blast-induced mTBI.

    abstract:PURPOSE:To evaluate objectively and quantitatively human pupillary responses to a light stimulus under photopic conditions in individuals with non-blast-induced, chronic, mild traumatic brain injury (mTBI). METHODS:Seventeen individuals with chronic, non-blast-induced mTBI and 15 visually-normal (VN) controls were tes...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1045029

    authors: Thiagarajan P,Ciuffreda KJ

    更新日期:2015-01-01 00:00:00

  • Participation after traumatic brain injury: the surplus value of social cognition tests beyond measures for executive functioning and dysexecutive behavior in a statistical prediction model.

    abstract::Objective: This study evaluates the contribution of measures for social cognition (SC), executive functioning (EF) and dysexecutive behavior to the statistical prediction of social and vocational participation in patients with traumatic brain injury (TBI), taking into account age and injury severity.Method: A total of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1531303

    authors: Westerhof-Evers HJ,Fasotti L,van der Naalt J,Spikman JM

    更新日期:2019-01-01 00:00:00

  • Kinematic analysis of jaw function in children following traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To investigate jaw movements in children following traumatic brain injury (TBI) during speech using electromagnetic articulography (EMA). METHODS AND PROCEDURES:Jaw movements of two non-dysarthric children (aged 12.75 and 13.08 years) who had sustained a TBI were recorded using the AG-100 EMA system ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050400025083

    authors: Loh EW,Goozée JV,Murdoch BE

    更新日期:2005-07-01 00:00:00

  • Patient perspectives on quality and access to healthcare after brain injury.

    abstract:PRIMARY OBJECTIVE:To gather information about brain injury (BI) survivors' long-term healthcare needs, quality, barriers and facilitators. RESEARCH DESIGN:Qualitative content analysis of data gathered in focus groups using semi-structured interviews. METHODS:Forty-four community-dwelling adults participated at two cl...

    journal_title:Brain injury

    pub_type: 杂志文章,多中心研究

    doi:10.1080/02699052.2018.1429024

    authors: Dams-O'Connor K,Landau A,Hoffman J,St De Lore J

    更新日期:2018-01-01 00:00:00

  • The use of cranial electrotherapy stimulation in the treatment of closed-head-injured patients.

    abstract::This double-blind study sought to discover if cranial electrotherapy stimulation (CES), which is a known treatment of depression, anxiety and insomnia in non-head-injured patients, could be an effective, drug-free treatment of stress-related symptoms in the closed-head-injured (CHI) patient. In this study 10 CHI patie...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/02699059409150986

    authors: Smith RB,Tiberi A,Marshall J

    更新日期:1994-05-01 00:00:00

  • Consequences of cognitive impairments following traumatic brain injury: Pilot study on visual exploration while driving.

    abstract:PRIMARY OBJECTIVE:The aim was to assess the visual exploration of a person suffering from traumatic brain injury (TBI). It was hypothesized that visual exploration could be modified as a result of attentional or executive function deficits that are often observed following brain injury. RESEARCH DESIGN:This study comp...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699051003692159

    authors: Milleville-Pennel I,Pothier J,Hoc JM,Mathé JF

    更新日期:2010-01-01 00:00:00

  • Suicide in professional American football players in the past 95 years.

    abstract:OBJECTIVE:To examine publicly-available information on all identified cases of suicide in active or former American professional football players between 1920 and the spring of 2015. DESIGN:Retrospective cohort study. SETTING:Professional American Football in the US. PARTICIPANTS:A cohort of 26 702 athletes who had ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2016.1202451

    authors: Webner D,Iverson GL

    更新日期:2016-01-01 00:00:00

  • The Visual Response Evaluation: a pilot study of an evaluation tool for assessing visual responses in low-level brain-injured patients.

    abstract::The Visual Response Evaluation (VRE) was developed to meet the need for a formal and in-depth measure of visual responses in low-level brain-injured persons (Rancho Levels II and III) and to monitor and document minute changes in the recovery of these patients. Often, patients at these low functional levels exhibit li...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059109008101

    authors: Davis AL

    更新日期:1991-07-01 00:00:00

  • A systematic review of treatments for mild traumatic brain injury.

    abstract:OBJECTIVES:To assess the effectiveness of interventions for mild traumatic brain injury (MTBI) in adults as found in the literature. RESEARCH DESIGN:Systematic review of the literature. METHODS:Six electronic databases and 18 journals within the brain injury field were manually searched between the years 1980-2003. R...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050400025042

    authors: Comper P,Bisschop SM,Carnide N,Tricco A

    更新日期:2005-10-01 00:00:00

  • Neuropsychological test validity in Veterans presenting with subjective complaints of 'very severe' cognitive symptoms following mild traumatic brain injury.

    abstract:OBJECTIVE:This study explored the utility of combining data from measures of performance validity and symptom validity among Veterans undergoing neuropsychological evaluation for mild traumatic brain injury (mTBI). BACKGROUND:Persistent cognitive impairments following mTBI are often reported by returning combat vetera...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2016.1218546

    authors: Spencer RJ,Waldron-Perrine B,Drag LL,Pangilinan PH,Axelrod BN,Bieliauskas LA

    更新日期:2017-01-01 00:00:00

  • Senior fitness test; a useful tool to measure physical fitness in persons with acquired brain injury.

    abstract:OBJECTIVES:To evaluate the feasibility and usability of the senior fitness test (SFT) in persons with acquired brain injury (ABI). METHODS:A pilot cohort design with a convenience sample of persons with ABI was used. RESULTS:Persons with ABIs (n = 47) were younger than their healthy counterparts (n = 172) were but pe...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1540796

    authors: Langhammer B,Stanghelle JK

    更新日期:2019-01-01 00:00:00

  • Quality-of-life and psychosocial outcome following childhood arterial ischaemic stroke.

    abstract:OBJECTIVES:This study investigates psychosocial outcome and quality-of-life in children who have experienced arterial ischaemic stroke (AIS), using a multidimensional and multi-perspective approach. It also examines the predictors of quality-of-life following childhood AIS. METHOD:Forty-nine children between 6-18 year...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.661117

    authors: O'Keeffe F,Ganesan V,King J,Murphy T

    更新日期:2012-01-01 00:00:00

  • Spasticity after stroke: physiology, assessment and treatment.

    abstract:BACKGROUND:Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this disorder, however, are not well understood. METHOD:This review aims to define spasticity, describe hypotheses explaining its development after a stroke, give an overview of related neuroimaging studies as well as a...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2013.804202

    authors: Thibaut A,Chatelle C,Ziegler E,Bruno MA,Laureys S,Gosseries O

    更新日期:2013-01-01 00:00:00

  • Cognitive interventions post acquired brain injury.

    abstract:OBJECTIVE:Cognitive rehabilitation represents a substantial portion of rehabilitative efforts put forth in increasing independence following an acquired brain injury. MAIN OUTCOMES AND RESULTS:This review examined four major areas of cognitive therapy including: attention/concentration, learning and memory, executive ...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050701201813

    authors: Rees L,Marshall S,Hartridge C,Mackie D,Weiser M,Erabi Group.

    更新日期:2007-02-01 00:00:00

  • Pharmacological management of Dysautonomia following traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To document and critically evaluate the likely effectiveness of pharmacological treatments used in a sample of patients with Dysautonomia and to link these findings to previously published literature. RESEARCH DESIGN:Retrospective case control chart review. METHODS AND PROCEDURES:Data were collected...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050310001645775

    authors: Baguley IJ,Cameron ID,Green AM,Slewa-Younan S,Marosszeky JE,Gurka JA

    更新日期:2004-05-01 00:00:00