Abstract:
PRIMARY OBJECTIVE:To examine the neuroprotection of baicalin, a flavonoid compound derived from the dried root of Scutellaria baicalensis Georgi, on neurons. RESEARCH DESIGN:A rat PC12 cell line was used to study the neuroprotection and possible mechanisms of baicalin on H₂O₂-induced neuron damage. METHODS:Three anti- and one pro-apoptosis genes in PC12 cells were examined. Cell apoptosis was induced by H₂O₂ and apoptotic rate was obtained by flow cytometry. MTT for cell viability, immunofluorescence microscopy for promoter activity and western blot for gene expression were also employed. RESULTS:Data of MTT reduction assay and flow cytometry revealed that viability loss and apoptotic rate were reduced by pre-treatment of PC12 cells with baicalin for 24 hours. Baicalin was also found to increase SOD, GSH-Px activities and to decrease MDA level. Results from Western blot and immunofluorescence microscopy showed baicalin increased the expressions of survivin, Bcl-2 and p-STAT3 and decreased caspase-3 expression which were attenuated by AG-490. CONCLUSIONS:The results point to the possibility of the neuroprotective effects of baicalin on neuronal apoptosis induced by oxidative stress and indicate that activation of the JAK/STAT signalling pathway might involve the anti-apoptotic effect of baicalin.
journal_name
Brain Injjournal_title
Brain injuryauthors
Zheng WX,Wang F,Cao XL,Pan HY,Liu XY,Hu XM,Sun YYdoi
10.3109/02699052.2013.860469subject
Has Abstractpub_date
2014-01-01 00:00:00pages
227-34issue
2eissn
0269-9052issn
1362-301Xjournal_volume
28pub_type
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