Abstract:
PRIMARY OBJECTIVE:To study the effect of flavonoids isolated from aerial parts of Scutellaria baicalensis Georgi (SSF) on cerebral damage induced by okadaic acid (OA) in rats. METHODS AND PROCEDURES:OA was microinjected into the right lateral ventricle of male rats at a dose of 200 ng kg(-1) twice with a 3-day interval between injections to establish a model of Alzheimer's-disease-like cerebral damage. Neuronal morphology was observed with thionin staining and the expressions of glial fibrillary acidic protein (GFAP) and β-amyloid peptide 1-40 (Aβ1-40) were monitored via immunohistochemistry. The level of malondialdehyde (MDA) and the activities of glutathione peroxidase (GSH-Px) and lactate dehydrogenase (LDH) were measured using spectrophotometry. MAIN OUTCOMES AND RESULTS:The results showed that OA-treated rats exhibited marked neuronal damage accompanied by increased levels of Aβ1-40 peptide and MDA accumulation, decreased GFAP protein expression and reduced GSH-Px and LDH activity in the brain. SSF at three doses (25, 50 and 100 mg kg(-1)) dramatically reversed the OA-induced changes in the brains of rats. CONCLUSION:SSF-mediated amelioration of OA-induced neuronal damage in rats provides a rationale for assessing SSF as a means of to reducing tau hyperphosphorylation and Aβ expression in the treatment of Alzheimer's disease.
journal_name
Brain Injjournal_title
Brain injuryauthors
Zhang SF,Dong YC,Zhang XF,Wu XG,Cheng JJ,Guan LH,Shang YZdoi
10.3109/02699052.2015.1042053subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1376-82issue
11eissn
0269-9052issn
1362-301Xjournal_volume
29pub_type
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