Pharmacological management of Dysautonomia following traumatic brain injury.

Abstract:

PRIMARY OBJECTIVE:To document and critically evaluate the likely effectiveness of pharmacological treatments used in a sample of patients with Dysautonomia and to link these findings to previously published literature. RESEARCH DESIGN:Retrospective case control chart review. METHODS AND PROCEDURES:Data were collected on age, sex and GCS matched subjects with and without Dysautonomia (35 cases and 35 controls). Data included demographic and injury details, physiological parameters, medication usage, clinical progress and rehabilitation outcome. Descriptive analyses were undertaken to characterize the timing and frequency of CNS active medications. MAIN OUTCOMES AND RESULTS:Dysautonomic patients were significantly more likely to receive neurologically active medications. A wide variety of drugs were utilised with the most frequent being morphine/midazolam and chlorpromazine. Cessation of morphine/midazolam produced significant increases in heart rate and respiratory rate but not temperature. Chlorpromazine may have modified respiratory rate responses, but not temperature or heart rate. CONCLUSIONS:The features of Dysautonomia are similar to a number of conditions treated as medical emergencies. Despite this, no definitive treatment paradigm exists. The best available evidence is for morphine (especially intravenously), benzodiazepines, propanolol, bromocriptine and possibly intrathecal baclofen. Barriers to improving management include the lack of a standardized nomenclature, formal definition or accepted diagnostic test. Future research needs to be conducted to improve understanding of Dysautonomia with a view to minimizing disability.

journal_name

Brain Inj

journal_title

Brain injury

authors

Baguley IJ,Cameron ID,Green AM,Slewa-Younan S,Marosszeky JE,Gurka JA

doi

10.1080/02699050310001645775

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

409-17

issue

5

eissn

0269-9052

issn

1362-301X

pii

EA5NQ18CL8T1K34K

journal_volume

18

pub_type

杂志文章
  • ICU sedation with dexmedetomidine after severe traumatic brain injury.

    abstract:OBJECTIVE:To comprehensively describe the use of dexmedetomidine in a single institutional series of adult ICU patients with severe TBI. This study describes the dexmedetomidine dosage and infusion times, as well as the physiological parameters, neurological status and daily narcotic requirements before, during and aft...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2016.1187289

    authors: Humble SS,Wilson LD,Leath TC,Marshall MD,Sun DZ,Pandharipande PP,Patel MB

    更新日期:2016-01-01 00:00:00

  • Further development of the response scales of the Acquired Brain Injury Challenge Assessment (ABI-CA).

    abstract:PRIMARY OBJECTIVE:To revise the scaling of the response sets of the Acquired Brain Injury Challenge Assessment (ABI-CA) through expert input and determination of empirically based cut-points. RESEARCH DESIGN:A measurement development study with a content validity focus. METHODS:Response option wording was revised thr...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2013.809551

    authors: McArthur C,Venkatesh S,Warren D,Pringle D,Doerr T,Salbach NM,Kirkwood G,Wright V

    更新日期:2013-01-01 00:00:00

  • Sleep Disturbances in Young Adults with Childhood Traumatic Brain Injury: Relationship with Fatigue, Depression, and Quality of Life.

    abstract:OBJECTIVE:This study assessed the consequences of childhood traumatic brain injury (TBI) on sleep, fatigue, depression, and quality of life (QoL) outcomes and explored the relationships between these variables at 20 years following childhood TBI. PARTICIPANTS:We followed up 54 young adults with mild, moderate, and sev...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1832704

    authors: Botchway EN,Godfrey C,Ryan NP,Hearps S,Nicholas CL,Anderson VA,Catroppa C

    更新日期:2020-10-14 00:00:00

  • Spasticity after stroke: physiology, assessment and treatment.

    abstract:BACKGROUND:Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this disorder, however, are not well understood. METHOD:This review aims to define spasticity, describe hypotheses explaining its development after a stroke, give an overview of related neuroimaging studies as well as a...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2013.804202

    authors: Thibaut A,Chatelle C,Ziegler E,Bruno MA,Laureys S,Gosseries O

    更新日期:2013-01-01 00:00:00

  • A QEEG index of level of functional dependence for people sustaining acquired brain injury: the Seville Independence Index (SINDI).

    abstract:PRIMARY OBJECTIVE:To find an easy-to-use, valid and reliable tool for evaluating the level of functional dependence of an individual with brain damage who seeks a diagnosis of his/her functional dependence in daily activities. METHODS:Eighty-one patients with acquired brain injury (ABI) in post-acute phase, 40 traumat...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701824143

    authors: Leon-Carrion J,Martin-Rodriguez JF,Damas-Lopez J,Martin JM,Dominguez-Morales Mdel R

    更新日期:2008-01-01 00:00:00

  • Quantitative assessment of impairment in constructional ability by cube copying in patients with aphasia.

    abstract::Constructional apraxia was evaluated in patients with aphasia using a cube-copying task. It was assessed whether quantitative assessment of cube copying could be used to estimate the performance intelligence quotient (IQ) according to neuropsychological tests. Abnormality in the cube-copying test was observed in 42 of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050110102095

    authors: Maeshima S,Ueyoshi A,Matsumoto T,Boh-Oka S,Yoshida M,Itakura T

    更新日期:2002-02-01 00:00:00

  • Voluntary exercise enhances survival and migration of neural progenitor cells after intracerebral haemorrhage in mice.

    abstract:PRIMARY OBJECTIVE:This study explored the long-term effects of exercise on the proliferation, survival and migration of endogenous neural progenitor cells (NPCs) in the subventricular zone (SVZ) of the brain after intracerebral haemorrhage (ICH). RESEARCH DESIGN:ICH was induced by an injection of collagenase into the ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699051003610458

    authors: Jin J,Kang HM,Park C

    更新日期:2010-01-01 00:00:00

  • Understanding the 'miserable minority': a diasthesis-stress paradigm for post-concussional syndrome.

    abstract::Opinions about persisting post-concussional symptoms after minor traumatic brain injury still reflect a polarization of views around the sterile debate concerning the psychological vs organic origins of symptoms. Reviews of the experimental literature do not always integrate the often diverse perspectives that explain...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050410001675906

    authors: Wood RL

    更新日期:2004-11-01 00:00:00

  • Factors increasing the risk of suicide after traumatic brain injury: a state-of-the-science review of military and civilian studies.

    abstract::Primary Objective: Survey TBI literature to identify evidence of risk for post-injury suicide. Literature Selection: Search terms ((traumatic brain injury OR TBI) AND (suicidality OR suicidal behaviour OR suicidal ideation)) entered in PubMed, OVID Medline, PsychInfo, and Web of Science for papers published in print 0...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1861656

    authors: McIntire KS,Crawford KA,Perrin PB,Sestak JL,Aman K,Walter LA,Page DB,Wen H,Randolph BO,Brunner RC,Novack TL,Niemeier JP

    更新日期:2021-01-18 00:00:00

  • Mild traumatic brain injury in an insured population: subjective complaints and return to employment.

    abstract::The great majority of traumatic brain injury (TBI) is of mild severity, with Glasgow Coma Scores (GCS) of 13-15, post-traumatic amnesia of less than 48 hours and brief, if any, hospitalization. All mild TBI admissions to hospital were provided with education in the form of a brief interview and a brochure on minor hea...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059209029654

    authors: Englander J,Hall K,Stimpson T,Chaffin S

    更新日期:1992-03-01 00:00:00

  • Development and validity of the Brain Injury Alert (BI Alert) screening tool for cognitive, emotional and social problems after paediatric acquired brain injury.

    abstract:PURPOSE:Validation of a new screening tool, viz., the Brain Injury Alert (BI Alert) for identification of cognitive and emotional problems after traumatic brain injury (TBI) in children. METHODS:Parents and teachers of children with TBI as well as controls were interviewed using the BI Alert. Validity was determined u...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2011.580311

    authors: Rasquin S,van Heugten C,Winkens I,Ritzen W,Hendriksen J,Vles H

    更新日期:2011-01-01 00:00:00

  • Psychosis secondary to traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) can result in serious and disabling neuropsychiatric disorders. METHOD:The authors report a case of a 51-year old male, admitted to the psychiatric ward for acute psychosis and suicidal ideation, probably associated with TBI. After a temporal head trauma he initiated auditory/ve...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050902800918

    authors: Guerreiro DF,Navarro R,Silva M,Carvalho M,Gois C

    更新日期:2009-04-01 00:00:00

  • Biochemical and physiological parameters of recovery in acute severe head injury: responses to multisensory stimulation.

    abstract::We investigated the efficacy of applying a programme of multisensory stimulation to patients with severe diffuse traumatic brain injury, during their admission to a tertiary neurosurgical intensive care unit. We attempted to determine the nature and extent of any physiological or biochemical changes occurring as a res...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/02699059309008176

    authors: Johnson DA,Roethig-Johnston K,Richards D

    更新日期:1993-11-01 00:00:00

  • Participation after traumatic brain injury: the surplus value of social cognition tests beyond measures for executive functioning and dysexecutive behavior in a statistical prediction model.

    abstract::Objective: This study evaluates the contribution of measures for social cognition (SC), executive functioning (EF) and dysexecutive behavior to the statistical prediction of social and vocational participation in patients with traumatic brain injury (TBI), taking into account age and injury severity.Method: A total of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1531303

    authors: Westerhof-Evers HJ,Fasotti L,van der Naalt J,Spikman JM

    更新日期:2019-01-01 00:00:00

  • Cognitive rehabilitation with right hemifield eye-patching for patients with sub-acute stroke and visuo-spatial neglect: a randomized controlled trial.

    abstract:OBJECTIVE:To assess whether, following a right-hemisphere stroke, the combined administration of computer-based cognitive rehabilitation and right hemifield eye-patching in patients with visuo-spatial neglect is more effective than computer-based cognitive rehabilitation alone. METHODS:Twelve patients were randomized ...

    journal_title:Brain injury

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/02699052.2014.995230

    authors: Aparicio-López C,García-Molina A,García-Fernández J,Lopez-Blazquez R,Enseñat-Cantallops A,Sánchez-Carrión R,Muriel V,Tormos JM,Roig-Rovira T

    更新日期:2015-01-01 00:00:00

  • Bispectral index as a predictor of unsalvageable traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:We aimed to assess the utility of bispectral index (BIS) monitoring to diagnose brain death (BD) in patients with severe traumatic brain injury (TBI). RESEARCH DESIGN AND METHODS:A prospective observational study was conducted for patients with severe TBI between 2012 and 2014. MAIN OUTCOMES AND RES...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1330966

    authors: Mahmood S,El-Menyar A,Shabana A,Mahmood I,Asim M,Abdelrahman H,Al-Thani H

    更新日期:2017-01-01 00:00:00

  • Screening for substance abuse in individuals with traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To determine the utility of the CAGE, the Brief Michigan Alcohol Screening Test (BMAST) and the Substance Abuse Subtle Screening Inventory (SASSI-3) with individuals with traumatic brain injury (TBI), two studies were conducted examining the accuracy, sensitivity and specificity of these instruments. ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/0269905031000149506

    authors: Ashman TA,Schwartz ME,Cantor JB,Hibbard MR,Gordon WA

    更新日期:2004-02-01 00:00:00

  • The 'dice' game: a new test of pragmatic language skills after closed-head injury.

    abstract::There are few clinical tools available to assess communication skills following closed-head injury. This paper describes one such task in which the subject is required to explain a board game to a naive listener. The explanation is taped, transcribed and the content is quantified. Reliability studies demonstrated that...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008197

    authors: McDonald S,Pearce S

    更新日期:1995-04-01 00:00:00

  • Functional improvement in severe head injury after readmission for rehabilitation.

    abstract::Early rehabilitation has been shown to minimize complications and optimize functional outcomes in head-injured patients. Although cognitive, behavioural and vocational issues continue for years after injury, many investigations maintain that physical improvement is limited after 6 months. At 12 months after injury, ex...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059209034951

    authors: Tuel SM,Presty SK,Meythaler JM,Heinemann AW,Katz RT

    更新日期:1992-07-01 00:00:00

  • The mediating effects of effort upon the relationship between head injury severity and cognitive functioning.

    abstract:PRIMARY OBJECTIVE:Given that poor effort may have a profound impact upon the results of neuropsychological assessment, it is of critical importance that assessment of effort is incorporated into the interpretation of a patient's neuropsychological profile. The current study examines the relationship between head injury...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/0269905031000070125

    authors: Moss A,Jones C,Fokias D,Quinn D

    更新日期:2003-05-01 00:00:00

  • Syria civil war: Outcomes of humanitarian neurosurgical care provided to Syrian wounded refugees in Israel.

    abstract:BACKGROUND:As an expected consequence of the civil war in Syria, emergent neurosurgical care for battlefield trauma has been provided for severely head-injured Syrians transferred to Northern Israel. METHODS:Sixty-six patients suffering from brain injury were brought to the border and then referred to the institution ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1043346

    authors: Barhoum M,Tobias S,Elron M,Sharon A,Heija T,Soustiel JF

    更新日期:2015-01-01 00:00:00

  • Seeing minds in patients with disorders of consciousness.

    abstract::Objective: To explore the ways in which health care professionals and families understand terms and concepts associated with disorders of consciousness.Methods: Open-ended, semi-structured interviews were conducted with 20 health care professionals and 18 family caregivers affiliated with a disorders of consciousness ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1706000

    authors: Peterson A,Kostick KM,O'Brien KA,Blumenthal-Barby J

    更新日期:2020-02-23 00:00:00

  • An overview of head injury: its consequences and rehabilitation.

    abstract::This article provides a broad overview of the consequences of head injury and approaches to its rehabilitation. Of necessity, no specific area is covered in depth. Sufficient references are provided, however, for the reader who desires further information in any of the areas discussed. It is hoped that, by providing t...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699058709034450

    authors: Vogenthaler DR

    更新日期:1987-07-01 00:00:00

  • False positive diagnosis of malingering due to the use of multiple effort tests.

    abstract:OBJECTIVE:Effort indicators are used to determine if neuropsychological test results are valid measures of a patient's cognitive abilities. The use of multiple effort measures is often advocated, but the false positive rate for multiple indicators depends on the number of measures used and the correlation among indicat...

    journal_title:Brain injury

    pub_type: 杂志文章,meta分析,评审

    doi:10.3109/02699052.2013.793400

    authors: Berthelson L,Mulchan SS,Odland AP,Miller LJ,Mittenberg W

    更新日期:2013-01-01 00:00:00

  • Early motor predictors of recovery in patients with severe traumatic brain injury.

    abstract:RESEARCH DESIGN:Retrospective observational study. OBJECTIVE:To compare motor variables between patients with severe traumatic brain injury who emerge and patients who do not emerge from vegetative state, in an attempt to identify early motor manifestations associated with consistent patient improvement. METHODS AND ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.661911

    authors: Tamashiro M,Cozzo D,Mattei M,Salierno F,Rivas ME,Alzúa O,Olmos L,Bonamico L,Leiguarda R

    更新日期:2012-01-01 00:00:00

  • Virtual reality gaming as a neurorehabilitation tool for brain injuries in adults: A systematic review.

    abstract:OBJECTIVE:Evidence of the effectiveness of virtual reality (VR) in motor and cognitive rehabilitation for traumatic brain injury (TBI) continues to be mixed. Therefore, we conducted a systematic literature review in accordance with PRISMA guidelines to strategically evaluate the strength of evidence supporting the use ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1802779

    authors: Aulisio MC,Han DY,Glueck AC

    更新日期:2020-08-23 00:00:00

  • Neuropsychological outcome and community re-integration following traumatic brain injury: the impact of frontal and non-frontal lesions.

    abstract:PRIMARY OBJECTIVE:To examine the relationship between cortical lesion location and brain injury outcome. It was hypothesized that focal frontal lesions after traumatic brain injury (TBI) would result in decreased executive and memory functioning and poor community participation outcome. RESEARCH DESIGN:Three quasi-exp...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/0269905040004310

    authors: Lehtonen S,Stringer AY,Millis S,Boake C,Englander J,Hart T,High W,Macciocchi S,Meythaler J,Novack T,Whyte J

    更新日期:2005-04-01 00:00:00

  • The combined use of amantadine and l-dopa/carbidopa in the treatment of chronic brain injury.

    abstract::The frontal lobes are particularly vulnerable to injury during trauma. The syndrome commonly attributed to frontal lobe dysfunction includes problems with impulsivity, perseveration, disinhibition, amotivation, attention, planning, and problem solving. These symptoms can respond to certain pharmacologic interventions,...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123430

    authors: Kraus MF,Maki P

    更新日期:1997-06-01 00:00:00

  • After traumatic brain injury: a discussion of consequences.

    abstract::Traumatic brain injury is followed by many changes in cognition, emotion, social interaction and functioning, and communication. These changes may range from severe to subtle. They create complex difficulties for the individual and his or her network of support. Presented here is a review of the literature on the chan...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699059409151016

    authors: Stratton MC,Gregory RJ

    更新日期:1994-10-01 00:00:00

  • Misconceptions about brain injury: a survey replication study.

    abstract:PRIMARY OBJECTIVE:The researchers sought to update information about the public's knowledge about brain injury and to document progress made toward correcting misconceptions. RESEARCH DESIGN:Survey replication. METHODS AND PROCEDURES:Three hundred and eighteen respondents from the lay public answered questions about ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050600676784

    authors: Hux K,Schram CD,Goeken T

    更新日期:2006-05-01 00:00:00