Abstract:
:In pancreatic beta-cells, stimulation of insulin secretion by glucose and other nutrients requires metabolism of these nutrients to acetyl-CoA. Circumstantial evidence suggests that the conversion of acetyl-CoA to malonyl-CoA, which is a powerful inhibitor for carnitine palmitoyltransferase 1 and fatty acid oxidation, leads to insulin exocytosis, presumably by fatty acyl-CoA activation of certain ion channels. Since acetyl-CoA carboxylase (ACC) is the only enzyme which synthesizes malonyl-CoA, we generated transfectants of INS-1 cells which express antisense ACC mRNA in order to unequivocally establish that ACC is involved in glucose-induced insulin secretion. These cells showed lower ACC mRNA, protein and enzymatic activity than those of the control cells. Insulin secretion induced by nutrients such as glucose, amino acids, ketoisocaproate, and fatty acids was diminished commensurate with the level of ACC, while KCl induced insulin secretion was not affected.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Zhang S,Kim KHdoi
10.1006/bbrc.1996.1868subject
Has Abstractpub_date
1996-12-24 00:00:00pages
701-5issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(96)91868-9journal_volume
229pub_type
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