[Concentrations of diclofenac in aqueous humor and in plasma after i.v. injection in 59 patients undergoing cataract surgery--a prospective study].

Abstract:

BACKGROUND:The mean diclofenac level in the aqueous humor after i.v.-injection should be examined as an example for other systemic applied drugs. The clinical effect is to be evaluated with regard to perioperative anti-inflammatory therapy in patients undergoing cataract surgery. PATIENTS AND METHODS:In this prospective clinical study 59 patients (age 41-86 years) scheduled for phacoemulsification by the tunnel technique, received 75 mg diclofenac-sodium by short time i.v.-infusion (30 min) within an interval between 30 min and 7 h before surgery. Aqueous humor samples and one blood sample were taken at the beginning, and a second blood sample was taken at different time intervals before surgery. RESULTS:The plasma concentration of diclofenac one minute after infusion was 13,961 +/- 4277 ng/ml. The concentration decreased rapidly during the distribution phase (1305 +/- 324 ng/ml after 40 min) and reached after 336 min 419 +/- 277 ng/ml. A concentration of 83.9 ng/ml diclofenac was found for the last sampling point after 353 min in the elimination phase. The mean diclofenac concentration in the aqueous humor reached after about 60 min the highest level (21.7 +/- 12.7 ng/ml). This level decreases to 4.4 +/- 0.4 ng/ml (120 min) and 3.1 +/- 1.3 ng/ml (300 min), respectively. CONCLUSIONS:The calculated mean residence time of diclofenac molecules in aqueous humor of 123 min matched the mean disposition residence time of diclofenac in the body (119 min).

journal_name

Klin Monbl Augenheilkd

authors

Struck HG,Bariszlovich A,Kuhlmann O,Weiss M

doi

10.1055/s-2001-12250

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

85-8

issue

2

eissn

0023-2165

issn

1439-3999

journal_volume

218

pub_type

临床试验,杂志文章,随机对照试验
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  • [Risk factors in patients with amaurosis fugax].

    abstract:BACKGROUND:In the diagnosis of retinal and cerebral vascular occlusion and migraine amaurosis fugax may be an important symptom. To evaluate the relation between cardiovascular diseases and amaurosis fugax we investigated the risk factors in patients with amaurosis fugax. MATERIALS AND METHODS:Twenty-four patients (14...

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    doi:10.1055/s-2008-1035368

    authors: Guhlmann M,Kommerell G

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:10.1055/s-2008-1057270

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  • [A contribution of the course of vitreous haemorrhage (author's transl)].

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    doi:

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    更新日期:1976-10-01 00:00:00

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Strempel I

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  • [Useful examinations and therapies in immunologic diseases].

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    pub_type: 杂志文章,评审

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  • [Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 2017].

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  • [46-year follow up of malignant transformation of choroid nevus with vascularized surface drusen].

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    doi:10.1055/s-2008-1046005

    authors: Daicker B

    更新日期:1991-05-01 00:00:00

  • [Suggestions for the design of a modern anomaloscope].

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    doi:10.1055/s-2008-1055221

    authors: Bockelmann WD

    更新日期:1982-10-01 00:00:00

  • Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.

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  • [Pressure lowering effect and side effects of 0.5% and 1.0% levobunolol eyedrops, compared with 0.5% timolol eyedrops in patients with open-angle glaucoma].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1985-12-01 00:00:00

  • [Computer-assisted multimedia interactive learning program "Primary Open-Angle Glaucoma"].

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    doi:

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    更新日期:1996-05-01 00:00:00

  • [Inverted In Vitro Confocal Microscopy in Mycotic Keratitis with Corneal Endothelial Epithelial Decompensation].

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  • [Myopic implant of the posterior chamber using a flexible Collamer lens].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

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  • Die randunscharfe Papille: eine diagnostische Herausforderung.

    abstract::Correct differential diagnosis in cases of blurred optic disc margins is a challenging task for ophthalmologists. The reliable differentiation of pseudopapilloedema and true papilloedema has significant implications for proper patient management. Conditions that give rise to pseudopapilloedema include small crowded di...

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    pub_type: 杂志文章,评审

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