Abstract:
:The authors examined the association between the use of diethylstilbestrol during pregnancy and the risk of subsequent fatal breast cancer in a large prospective study of US adults. After 9 years of follow-up, 1,574 cases of fatal breast cancer were observed among 501,536 gravid women who reported no prior history of cancer in 1982. Results from Cox proportional hazards models showed a positive association between a history of diethylstilbestrol exposure (reported by 3.9% of all women) and fatal breast cancer (adjusted rate ratio = 1.34, 95% confidence interval 1.06-1.69). This excess risk did not increase over time; women who were exposed more than 35 years ago (rate ratio = 1.35, 95% confidence interval 0.97-1.87) were not at greater risk than women who were exposed within the past 35 years (rate ratio = 1.39, 95% confidence interval 1.01-1.93). The positive association was not observed in women who used diethylstilbestrol before age 25 years but was seen at all other ages. The age of study participants did not modify the association between exposure and breast cancer, and there were no significant interactions between ever use of diethylstilbestrol and any of the other potential risk factors included in the analysis. These findings are consistent with those of several other studies of diethylstilbestrol exposure and breast cancer.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Calle EE,Mervis CA,Thun MJ,Rodriguez C,Wingo PA,Heath CW Jrdoi
10.1093/oxfordjournals.aje.a008976subject
Has Abstractpub_date
1996-10-01 00:00:00pages
645-52issue
7eissn
0002-9262issn
1476-6256journal_volume
144pub_type
杂志文章abstract::Among the major sources of indoor air pollution are combustion by-products from heating and cooking. Concern is increasing that use of polluting heating and cooking sources can increase cancer risk. In Canada, most cooking and heating currently relies on electricity or natural gas, but, in the past, and still in some ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwk117
更新日期:2007-03-15 00:00:00
abstract::As economic development increases, puberty occurs at younger ages, and this could contribute to an increase in the incidence of cardiovascular diseases and hormone-related cancers. The factors that determine pubertal timing are poorly understood. The growth axis that is active during puberty is active in the first 6 m...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr028
更新日期:2011-06-15 00:00:00
abstract::It is well established that women with a family history of breast cancer run a higher risk of breast cancer than do women without a family history. The evidence, however, is less clear regarding a possible association between a family history of breast cancer and risk of second primaries. The purpose of this prospecti...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a116566
更新日期:1992-10-15 00:00:00
abstract::Cigarette smoking is becoming increasingly common in Asia while quitting remains rare, in part because of a lack of knowledge about the risks of smoking. This study compared the risk of death from lung cancer associated with smoking habits in Australia and New Zealand and in Asia by using data from the Asia Pacific Co...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwm002
更新日期:2007-06-01 00:00:00
abstract::Recent developments in population mathematics apply to measurement issues in epidemiology. In particular, they demonstrate explicitly the relations that prevail among incidence, prevalence, case-fatality, mortality, and duration of illness in a population at a moment in time, rather than in a cohort of persons followe...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/126.2.336
更新日期:1987-08-01 00:00:00
abstract::Whether genetic and familial factors influence the association between cardiorespiratory fitness (CRF) and cardiovascular disease (CVD) is unknown. Two cohorts were formed based on data from 1,212,295 men aged 18 years who were conscripted for military service in Sweden during 1972-1996. The first comprised 4,260 twin...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa060
更新日期:2020-10-01 00:00:00
abstract::Using data from the National Institutes of Health-AARP Diet and Health Study, we evaluated the influence of adulthood weight history on mortality risk. The National Institutes of Health-AARP Diet and Health Study is an observational cohort study of US men and women who were aged 50-71 years at entry in 1995-1996. This...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt254
更新日期:2014-01-15 00:00:00
abstract::The relation of dietary factors and physical activity to hyperinsulinemia was examined in 389 men aged 70-89 years who participated in the Zutphen Elderly Study in 1990. Information about the usual diet was obtained using a cross-check dietary history, and habitual physical activity was assessed using a validated ques...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117257
更新日期:1994-08-15 00:00:00
abstract::Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr459
更新日期:2012-06-15 00:00:00
abstract::The authors investigated the risk of developing dementia for persons aged 50-75 years who suffered from Parkinson's disease, epilepsy, or severe head trauma. They compared the risk in this patient group with the risk in a reference group in a follow-up study based on the linked databases of three Dutch nationwide morb...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117597
更新日期:1995-12-15 00:00:00
abstract::Since a positive association between blood pressure and plasma glucose level in child populations has been observed previously, we studied this relationship in a stratified random sample of children ages 7-15 years drawn from a total geographic population. We stratified this population (N = 3524) by diastolic blood pr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113103
更新日期:1981-04-01 00:00:00
abstract::The safety and immunogenicity of a plasma-derived heat-inactivated hepatitis B vaccine (CLB) were evaluated in 471 healthy human volunteers, who, both in their occupations and in their private lives, had been at minimal risk of being infected with hepatitis B virus. The first 202 individuals received three 3-microgram...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.aje.a113936
更新日期:1984-11-01 00:00:00
abstract::Experiences of discrimination are associated with increased risk of adverse health outcomes; however, it is unknown whether discrimination is related to incident type 2 diabetes mellitus (diabetes). We investigated the associations of major experiences of discrimination (unfair treatment in 6 situations) and everyday ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx047
更新日期:2017-08-15 00:00:00
abstract::A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases -- 377 with cleft lip with or without cleft palate and 196 with cleft palate only -- and 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp040
更新日期:2009-05-15 00:00:00
abstract::Case-control studies involving more than two disease and referent categories may be analyzed by means of polychotomous logistic regression, an extension of the usual dichotomous logistic regression model. Although the standard method still may be used to compare the several disease subgroups in pairs, the polychotomou...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114338
更新日期:1986-06-01 00:00:00
abstract::To quantify nonresponse bias and estimate its potential impact, the authors compared census-based socioeconomic and demographic factors and geographic locations among respondents and nonrespondents in a multicenter case-control study of non-Hodgkin lymphoma (1998-2000). Using a geographic information system, the autho...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm292
更新日期:2008-02-01 00:00:00
abstract::The natural history of infection with human immunodeficiency virus type 1 (HIV-1) is characterized by a relentless decline in CD4-positive lymphocytes and the ultimate development of acquired immunodeficiency syndrome (AIDS). However, variables other than the CD4-positive lymphocyte level contribute to the measurement...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a116215
更新日期:1992-05-15 00:00:00
abstract::Single patient isolation of adults to prevent spread of infection was studied in five high occupancy community hospitals. The acceptable standard was a guideline for isolation in hospitals, published by the Center for Disease Control (CDC). Overusage of single patient isolation was found to vary between 4% and 96% of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112468
更新日期:1977-10-01 00:00:00
abstract::The isolation of chlamydial trachomatis in sera of patients with gon ococcal urethritis (GU), non-gonococcal urethritis (NGU), post-gonococca l urethritis (PGU) and trachomainclusion conjunctivitis (TRIC) is discussed. Chlamydiae were isolated in 40% of men with NGU, 20-30% with GU and 0-7% of men with symptomatic or...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a112243
更新日期:1976-05-01 00:00:00
abstract::Sequences of treatments that adapt to a patient's changing condition over time are often needed for the management of chronic diseases. An adaptive treatment strategy (ATS) consists of personalized treatment rules to be applied through the course of a disease that input the patient's characteristics at the time of dec...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz272
更新日期:2020-05-05 00:00:00
abstract::The association between four and two-thirds years incidence of coronary heart disease (CHD) and serum cholesterol, blood pressure (BP), height, body weight, cigarette smoking and physical activity at work and at leisure, was studied in 14,816 Oslo men, aged 40-49 years at entry to the study and free of cardiovascular ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112965
更新日期:1980-07-01 00:00:00
abstract::Of 8,006 men of Japanese ancestry living in Hawaii who were followed from 1966 to 1983 for incident cardiovascular disease, 1,381 died and 290 had a protocol autopsy which included determination of the extent of atherosclerosis in the coronary arteries and aorta. More than 50 biologic, lifestyle, and dietary character...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/126.2.214
更新日期:1987-08-01 00:00:00
abstract::The identity of the etiologic agent that caused the 1981 epidemic of toxic oil syndrome in Spain has not been established, and toxicologic study of oil specimens from the outbreak has been hampered by uncertainty about which oils were actually capable of causing illness. To identify chemical characteristics associated...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114914
更新日期:1988-06-01 00:00:00
abstract::The author evaluated the validity of four historically based variables collected on Georgia birth certificates: outcome of preceding pregnancy, history of delivery of a low- (<2,500 g) or high- (>4,000 g) birth-weight infant, and death of the baby resulting from the preceding pregnancy. Data were derived from birth an...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.10.883
更新日期:2001-11-15 00:00:00
abstract::The purpose of this study was to assess the effect of weight in middle-aged men and subsequent weight change on the risk of osteoporosis three decades later. The authors utilized data from 1,476 Norwegian men participating in two health screenings in Oslo (1972-1973 and 2000-2001) and Tromsø (1974-1975 and 2001). Heig...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn151
更新日期:2008-08-15 00:00:00
abstract::The relation of reproductive factors to risk of myocardial infarction in women aged 45-69 years was examined in a case-control interview study carried out in Massachusetts from 1986 to 1990. Each of 858 cases of first myocardial infarction was age-matched with a control from the same precinct of residence. Conditional...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116513
更新日期:1992-08-15 00:00:00
abstract::Although coronary heart disease (CHD) is currently the leading cause of death among American Indians, information on the prevalence of CHD and its association with known cardiovascular risk factors is limited. The Strong Heart Study was initiated in 1988 to quantify cardiovascular disease and its risk factors among th...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117632
更新日期:1995-08-01 00:00:00
abstract::Between December 21, 1969, and April 14, 1970, 44 symptomatic cases of Salmonella typhimurium gastroenteritis occurred among the approximately 2500 Sioux Indians of the Lake Traverse Reservation in South Dakota. Twenty-five cases were confirmed by positive stool culture. All 19 cases not confirmed by culture had diarr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112155
更新日期:1975-09-01 00:00:00
abstract::Explanations for the low prevalence of atherosclerosis in Japan versus the United States are often confounded with genetic variation. To help remove such confounding, the authors compared coronary artery calcification (CAC), a marker of subclinical atherosclerosis, between Japanese men in Japan and Japanese men in Haw...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm201
更新日期:2007-12-01 00:00:00
abstract::Early-onset cannabis use is widespread in many countries and might cause later onset of depression. Sound epidemiologic data across countries are missing. The authors estimated the suspected causal association that links early-onset (age <17 years) cannabis use with later-onset (age > or =17 years) risk of a depressio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq096
更新日期:2010-07-15 00:00:00