Abstract:
:Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2003 to 2004 and selected for a prior case-based study of PFCs and subfecundity. Maternal plasma samples were obtained around 17 weeks of gestation. Outcomes included birth weight z scores, preterm birth, small for gestational age, and large for gestational age. The adjusted birth weight z scores were slightly lower among infants born to mothers in the highest quartiles of PFCs compared with infants born to mothers in the lowest quartiles: for perfluorooctane sulfonate, β = -0.18 (95% confidence interval: -0.41, 0.05) and, for perfluorooctanoic acid, β = -0.21 (95% confidence interval: -0.45, 0.04). No clear evidence of an association with small for gestational age or large for gestational age was observed. Perfluorooctane sulfonate and perfluorooctanoic acid were each associated with decreased adjusted odds of preterm birth, although the cell counts were small. Whether some of the associations suggested by these findings may be due to a noncausal pharmacokinetic mechanism remains unclear.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Whitworth KW,Haug LS,Baird DD,Becher G,Hoppin JA,Skjaerven R,Thomsen C,Eggesbo M,Travlos G,Wilson R,Cupul-Uicab LA,Brantsaeter AL,Longnecker MPdoi
10.1093/aje/kwr459subject
Has Abstractpub_date
2012-06-15 00:00:00pages
1209-16issue
12eissn
0002-9262issn
1476-6256pii
kwr459journal_volume
175pub_type
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