Dialyzer reuse: interaction between dialyzer membrane, disinfectant (formalin), and blood during dialyzer reprocessing.

Abstract:

:The growing practice of dialyzer reuse in recent years is mainly based on medical and economic considerations. However, adverse reactions such as immunohemolytic anemia due to anti-Nform antibody associated with dialyzer reuse have been reported. In this study, scanning electron microscopy and cytologic staining were used to evaluate the interaction between blood components and the reprocessed synthetic dialyzer membrane (polysulfone) after disinfectant (formaldehyde) treatment. The results showed that various blood components such as fibrin and blood cells still adhered to the dialyzer membrane after reprocessing. The study also demonstrated that the adhered denatured blood components could be detached by sonication and/or simulated hemodialysis and then gain access into the circulation. The re-entry of the denatured blood components to the patients exposed to reused dialyzers may result in an enhanced immunological response which may contribute to antibody formation (such as anti-Nform antibody) with a reused hemodialyzer.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Ng YY,Yang AH,Wong KC,Lan HY,Hung TL,Kerr PG,Huang TP

doi

10.1111/j.1525-1594.1996.tb04418.x

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

53-5

issue

1

eissn

0160-564X

issn

1525-1594

journal_volume

20

pub_type

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