On the so-called MAC (Maximal Allowable Concentrations) for carcinogenic hydrocarbons.

Abstract:

:The paper deals with some results of work done in the USSR to establish maximal allowable doses (MAC) for the carcinogenic hydrocarbon benza(a)pyrene in human environment. At the same time it is a brief review of some discussions on this item which took place in USSR and on the international level.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Shabad LM

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

459-68

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

22

pub_type

杂志文章
  • Mucopolysaccharides in gastric cancer.

    abstract::The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysacchar...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Tichá V,Jansa P,Tichý M

    更新日期:1988-01-01 00:00:00

  • Sacharose density gradient separation of Ehrlich ascites carcinoma and L-5178Y tumor cells in different cell cycle phases.

    abstract::Optimal conditions were determined for the distribution of Ehrlich ascites carcinoma (EAC) and L-5178Y mouse tumor cells, proliferating in vivo, by their age within the cell cycle by sedimentation in a buffered linear sacharose density gradient. Measurements of cell size, DNA content and incorporation of tritiated thy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Horáková K,Fusková A,Ceglédyová N

    更新日期:1976-01-01 00:00:00

  • The clinical significance of MIA gene in tumorigenesis of lung cancer.

    abstract::Lung cancer is a common malignant disease in humans. Both the incidence rate and death rate keep growing in recent years and the prognosis of lung cancer patients is disappointing. Melanoma inhibitory activity (MIA) is a secreted protein and a serum marker for metastasis of melanoma. MIA was reported as an oncogene in...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_190511N422

    authors: Gu QH,Li D,Xie ZH,Shen QB

    更新日期:2020-05-01 00:00:00

  • Bilateral breast cancer.

    abstract::The aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. Thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in Greatpoland Cancer Cente...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Skowronek J,Piotrowski T

    更新日期:2002-01-01 00:00:00

  • Effect of testosterone on growth of P388 leukemia cell line in vivo and in vitro. Distribution of peripheral blood T lymphocytes and cell cycle progression.

    abstract::In transplanted mice, the P388 tumor grew better in castrated than in non castrated (NC) mice. The proportion of CD8+ in the blood was more numerous in NC mice. The T cell subsets (CD4+ and CD8+) were also high in the mice with small tumor tissue (<10 mg). The correlation observed between the tumor weight and T cell s...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Aboudkhil S,Henry L,Zaid A,Bureau JP

    更新日期:2005-01-01 00:00:00

  • Expression of p21 and MDM-2 proteins on tumor cells in responding and non-responding patients with Hodgkin's disease.

    abstract::Since the prevention of apoptosis can produce resistance to chemotherapy, abnormal expression of oncoproteins engaged in the regulation of this phenomenon in tumor cells may give some prognostic information in patients with neoplasma. To assess this problem in Hodgkin's disease (HD), the cellular expression of two p53...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Smolewski P,Niewiadomska H,Krykowski E,Robak T

    更新日期:1999-01-01 00:00:00

  • Tumor necrosis factor-alpha: molecular-biological aspects minireview.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Szatmáry Z

    更新日期:1999-01-01 00:00:00

  • Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography. II. Nucleosides of 6-azauracil.

    abstract::The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Novotný L,Vachálková A,Pískala A

    更新日期:1999-01-01 00:00:00

  • Electronic portal imaging registration in breast cancer radiotherapy verification: analysis of inter-observer agreement among different categories of health practitioners.

    abstract::Electronic portal imaging (EPI) is commonly used to identify and correct for inter-fraction variability in tangential breast irradiation. Based on the institutional policy, EPI registration is performed by either radiation oncologist or therapist. Little data is available on the inter-observer agreement in EPI registr...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_040

    authors: Jereczek-Fossa BA,Santoro L,Colangione SP,Morselli L,Fodor C,Vischioni B,Rozza D,Leppa A,Cambria R,Leonardi MC,Morra A,Baroni G,Zurrida S,Orecchia R

    更新日期:2013-01-01 00:00:00

  • Sensitivity of TSTA and species-specific cell membrane antigens of tumor cells to glutaraldehyde treatment.

    abstract::In vivo immunogenicity and in vitro species-specific membrane antigens in tumor cells treated or untreated with glutaraldehyde (GA) were studied. Two different syngeneic Syrian hamster transplantable tumor cell lines (spontaneous liver cancer and SV40-induced sarcoma) not only lost immunogenicity after GA treatment bu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kluchareva TE,Matveeva VA,Deichman GI

    更新日期:1978-01-01 00:00:00

  • Anti-tumor immunity elicited by cross-linking vaccine heat shock protein 72 and alpha-fetoprotein epitope peptide.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies over the world. Alpha-fetoprotein (AFP) is an oncofetal protein during HCC development, which could generate weaker and less reproducible antitumor protection, and may serve as a target for immunotherapy. Therefore, it is imperative to enhance its i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_085

    authors: Li Z,Wang XP,Lin HP,Xu B,Zhao Q,Qi BN,Yang YX,Wang ZR

    更新日期:2015-01-01 00:00:00

  • Sorafenib-irinotecan sequential therapy augmented the anti-tumor efficacy of monotherapy in hepatocellular carcinoma cells HepG2.

    abstract:UNLABELLED:The current study aimed to evaluate the efficacy of sorafenib-based combined therapy against hepatocellular carcinoma (HCC). HepG2 cells were exposed to sorafenib, irinotecan, and oxaliplatin and then subjected to MTT assay to determine chemosensitivity. Flow cytometry was used to examine cell cycle distribu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_022

    authors: Wang Z,Zhao Z,Wu T,Song L,Zhang Y

    更新日期:2015-01-01 00:00:00

  • Induction of tumor associated macrophage-mediated lysis of autologous tumor cells by lectins.

    abstract::Lectin dependent cell mediated cytotoxicity (LDCC) to autologous tumor cells (ATC) by the tumor associated macrophages (TAM) was studied by 4 h 51Cr release assays at early and late stages of growth of a murine transplantable ascites tumor, S-180, in presence of different concentrations of wheat germ agglutinin (WGA) ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Chattopadhyay U,Bhattacharyya S

    更新日期:1988-01-01 00:00:00

  • Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinoma.

    abstract::Podoplanin (D2-40) was shown to be expressed in cancer-associated fibroblasts (CAFs) of various malignancies. The study aimed at examining its impact on angiogenesis and lymphangiogenesis markers in invasive ductal carcinoma of the breast (IDC). The studies were performed on 104 archival cases of IDC using immunohisto...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_067

    authors: Pula B,Wojnar A,Witkiewicz W,Dziegiel P,Podhorska-Okolow M

    更新日期:2013-01-01 00:00:00

  • Human mammary gland associated antigens. Lack of D-type retravirus-induced antigens.

    abstract::Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kryukova IN,Bobrova TS

    更新日期:1977-01-01 00:00:00

  • Study of DOK4 gene expression and promoter methylation in sporadic breast cancer.

    abstract::The analysis of DNA methylation patterns in circulating cell-free DNA in body fluids is an analyte of great interest in clinical research. Downstream of Kinase (DOK) proteins represent a multigenic family of adaptors that includes negative regulators of immune cell signaling and plays important roles in signaling, cel...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_190811N747

    authors: Heidarizadi A,Salimi M,Mozdarani H

    更新日期:2020-07-01 00:00:00

  • Acute phase reactants and clinical stages in multiple myeloma.

    abstract::Serum levels of seven specific proteins mostly acute phase reactants (APR) have been studied (transferrin, alpha 2-macroglobulin, alpha 1-antitrypsin, haptoglobin, C3, ceruloplasmin, orosomucoid) in 14 healthy subjects and in 55 patients with multiple myeloma. The alpha 2-macroglobulin and transferrin are significantl...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: San Miguel J,Vicente V,Battle J,Hernandez F,Lopez Borrasca A

    更新日期:1981-01-01 00:00:00

  • Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.

    abstract::Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Wideł M,Watras J,Suwiński J,Salwińska E

    更新日期:1987-01-01 00:00:00

  • Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent a...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Cetin E,Cengiz B,Gunduz E,Gunduz M,Nagatsuka H,Bekir-Beder L,Fukushima K,Pehlivan D,N MO,Nishizaki K,Shimizu K,Nagai N

    更新日期:2008-01-01 00:00:00

  • Interactions between the growth effects of a kidney epithelial cell growth inhibitor and extracellular concentrations of cyclic nucleotides.

    abstract::The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of ser...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Fremuth F,Holley RW,Baldwin JH

    更新日期:1982-01-01 00:00:00

  • Vitamin E--its status and role in leukemia and lymphoma.

    abstract::A comparative study has been performed on the relationship between vitamin E and immunofunction in normal and malignant condition in human and murine systems. Further, the effects of supplemental vitamin E on tumor take, host survival and tumor growth have been studied in a transplantable lymphoma in mice. Vitamin E w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Dasgupta J,Sanyal U,Das S

    更新日期:1993-01-01 00:00:00

  • The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry.

    abstract::We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 30 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduc...

    journal_title:Neoplasma

    pub_type: 杂志文章,多中心研究

    doi:10.4149/neo_2009_01_76

    authors: Valkova V,Benesova K,Vitek A,Faber E,Mayer J,Zak P,Trneny M

    更新日期:2009-01-01 00:00:00

  • Nodal status in the papillary thyroid vancer. Comparison of the results of routine histopathological examination, immunohistochemistry and reverse transcription - polymerase chain reaction.

    abstract::Immunohistochemistry (IE) and polymerase chain reaction (PCR) are tools enabling to find small number of tumor cells in lymph nodes (LNs) or peripheral blood. Perhaps these methods will allow early detection of cell dissemination and refine risk group within papillary thyroid cancer (PTC) that might benefit from more ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kaczka K,Jakubiak-Wielganowicz M,Zawlik I,Ziolkowski R,Kuzdak K,Pomorski L

    更新日期:2008-01-01 00:00:00

  • FASAY: a simple functional assay in yeast for identification of p53 mutation in tumors.

    abstract::Alteration of the p53 tumor suppressor gene is the most common genetic defect known to occur in human tumors. Germ-line p53 mutations significantly increase the risk of developing diverse malignancies. FASAY is a simple functional assay for germ-line and somatic mutations in the p53 gene altering the transactivation c...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Smardová J

    更新日期:1999-01-01 00:00:00

  • Evaluation of phthalmustine, a new anticancer compound. II. Tumor inhibitory effect in murine Ehrlich ascites carcinoma and sarcoma-180.

    abstract::The antitumor activity of phthalmustine (Neoplasma, 41, 1994, 35) has been evaluated in murine Ehrlich ascites carcinoma (EAC) and sarcoma-180 (S-180). The hematological changes associated with the application of phthalmustine were also evaluated in tumor bearing as well as in normal male Swiss mice. The results indic...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Bhattacharya S,Ghosh M,Sadhu U,Dutta S,Sanyal U

    更新日期:1996-01-01 00:00:00

  • Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma.

    abstract::Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to inve...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_076

    authors: Ye YW,Jiang ZM,Li WH,Li ZS,Han YH,Sun L,Wang Y,Xie J,Liu YC,Zhao J,Tang AF,Li XX,Guan ZC,Gui YT,Cai ZM

    更新日期:2012-01-01 00:00:00

  • Significance of CEA, AFP, SP1 and HCG as tumor markers in ovarian carcinoma.

    abstract::The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. On the basis of the trials it was stated that a satisfactory correlation between the extension of the tumor and the serum CEA level was ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Pulay T,Csömör S,Mészáros K,Szarka G,Csabay L,Szinnyai A

    更新日期:1987-01-01 00:00:00

  • Alteration of the microRNA expression profile in human osteosarcoma cells transfected with APE1 siRNA.

    abstract::Apurinic/apyrimidinic endonuclease1 (APE1), which has the dual functions of DNA repair and redox regulation, is considered to be a promising potential target in cancer treatment. Microarray and qRT-PCR were used to confirm the change of miRNA followed by analysis with comprehensive bioinformatics-based analysis. Both ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_050

    authors: Dai N,Zhong ZY,Cun YP,Qing Y,Chen Ch,Jiang P,Li MX,Wang D

    更新日期:2013-01-01 00:00:00

  • The pattern of human lymph node involvement by the non-Hodgkin lymphomas of B-cell lineage.

    abstract::A total of 93 lymph nodes from 24 patients with a primary malignant non-Hodgkin lymphoma of B-cell lineage was assessed histologically with special reference to the presence or absence of neoplastic B-cells in the lymph node cortex and medulla (B-cell areas) as well as in the paracortical (T-cell area) area, and in th...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Syrjänen KJ

    更新日期:1979-01-01 00:00:00

  • Tumor microenvironment and the role of mesenchymal stromal cells.

    abstract:UNLABELLED:Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological pr...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:10.4149/neo_2013_001

    authors: Kucerova L,Skolekova S

    更新日期:2013-01-01 00:00:00