Abstract:
:In vivo temporal EPR imaging was conducted on the brain of rats that received one of two kinds of blood-brain barrier-permeable nitroxide radicals via the tail vein-one is a water-soluble 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (hydroxymethyl-PROXYL); and the other is a non-water-soluble 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM). From temporal EPR imaging data, temporal changes in the distribution of the nitroxide radical in the cerebral cortex, striatum, and hippocampus in the brain were investigated. It was found that the half-lives of the three parts in the brain of hydroxymethyl-PROXYL are longer and their EPR signal intensities are greater than those of PCAM.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Yokoyama H,Itoh O,Aoyama M,Obara H,Ohya H,Kamada Hdoi
10.1016/s0730-725x(02)00491-5subject
Has Abstractpub_date
2002-04-01 00:00:00pages
277-84issue
3eissn
0730-725Xissn
1873-5894pii
S0730725X02004915journal_volume
20pub_type
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