Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients.

abstract：:The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, ...

journal_title：Glycoconjugate journal

authors： Chatterjee A,Khatua S,Chatterjee S,Mukherjee S,Mukherjee A,Paloi S,Acharya K,Bandyopadhyay SK

更新日期：2013-11-01 00:00:00

abstract：:Influenza virus neuraminidase inhibitors (NAIs), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. Resistance to NAIs appears due to mutations in the active site of the neuraminidase (NA) molecule that decrease the NA enzymatic activity and sometimes in the hemagglutinin (H...

journal_title：Glycoconjugate journal

authors： Mochalova L,Bright R,Xu X,Korchagina E,Chinarev A,Bovin N,Klimov A

更新日期：2010-04-01 00:00:00

abstract：:Potato lectin (Solanum tuberosum agglutinin, STA) is an unusual glycoprotein containing approximately 50% carbohydrates by weight. Of the total carbohydrates, 92% is contributed by L: -arabinose, which are O-linked to hydroxyproline residues. The ferric chloride-orcinol assay (Bial's test), which is specific for pento...

journal_title：Glycoconjugate journal

authors： Pramod SN,Venkatesh YP

更新日期：2006-11-01 00:00:00

abstract：:The metabolism of glycosphingolipids is strictly regulated during the mitotic cell cycle. Before the G1-to-S transition, the ceramide and glucosylceramide concentration is elevated. Ceramide induces apoptosis synergistically with the pro-apoptotic protein prostate apoptosis response 4 (PAR-4) that may be asymmetricall...

journal_title：Glycoconjugate journal

authors： Bieberich E

更新日期：2004-01-01 00:00:00

abstract：:The rare N-unsubstituted glucosamine (GlcNH (3)(+)) residues in heparan sulfate (HS) have important biological and pathophysiological roles. However, it is difficult to prepare naturally-occuring, GlcNH(3)(+)-containing oligosaccharides from HS because of their low abundance, as well as the inherent problems in both e...

journal_title：Glycoconjugate journal

authors： Wei Z,Deakin JA,Blaum BS,Uhrín D,Gallagher JT,Lyon M

更新日期：2011-12-01 00:00:00

abstract：:In this study the comparative TLC immunostaining investigation of neutral GSLs and gangliosides from human skeletal and heart muscle is described. A panel of specific polyclonal and monoclonal antibodies as well as the GM1-specific choleragenoid were used for the overlay assays, combined with preceding neuraminidase t...

journal_title：Glycoconjugate journal

authors： Müthing J,Cacić M

更新日期：1997-01-01 00:00:00

abstract：:Carbohydrate-carbohydrate interaction is a reliable and versatile mechanism for cell adhesion and recognition. Glycosphingolipid (GSL) clusters at the cell membrane are mainly involved in this interaction. To investigate carbohydrate-carbohydrate interaction an integrated strategy (Glyconanotechnology) was developed. ...

journal_title：Glycoconjugate journal

authors： de la Fuente JM,Penadés S

更新日期：2004-01-01 00:00:00

abstract：:Trichomonas vaginalis causes the most common non-viral sexually transmitted infection linked to increased risk of premature birth, cervical cancer and HIV. This study defines molecular domains of the parasite surface glycoconjugate lipophosphoglycan (LPG) with distinct functions in the host immunoinflammatory response...

journal_title：Glycoconjugate journal

authors： Singh BN,Hayes GR,Lucas JJ,Sommer U,Viseux N,Mirgorodskaya E,Trifonova RT,Sassi RR,Costello CE,Fichorova RN

更新日期：2009-01-01 00:00:00

abstract：:Because anti-glycolipid antibodies are involved in the onset of several neurological diseases, the reactivity of glycolipids on erythrocytes and the probability of generating the antibodies were determined to clarify the contribution of glycolipids as antigens. Anti-erythrocyte antisera reacted with the following glyc...

journal_title：Glycoconjugate journal

authors： Iwamori M,Murata M,Toyoda M,Iwamori Y

更新日期：2009-05-01 00:00:00

abstract：:We have used two methods to evaluate the level of expression of Gb3Cer in several human leukaemia/lymphoma cell lines representative of the myeloid (K562, KG-1, HL-60, and lymphoid (Reh, Daudi, Raji, RPMI 8226, CCRF-CEM, MOLT-4) lineages blocked at varied stages of differentiation. TLC immunostaining of glycolipid ext...

journal_title：Glycoconjugate journal

authors： Stults CL,Larsen RD,Macher BA

更新日期：1995-10-01 00:00:00

abstract：:The TF, Tn, and SiaTn glycotopes are frequently expressed in cancer-associated mucins. Antibodies to these glycotopes were found in human serum. A set of polyacrylamide (PAA)--based glycoconjugates was applied to the direct and competitive enzyme-linked immunosorbent assays (ELISA) to characterize the specificity of s...

journal_title：Glycoconjugate journal

authors： Smorodin EP,Kurtenkov OA,Sergeyev BL,Pazynina GV,Bovin NV

更新日期：2004-01-01 00:00:00

abstract：:The small keratan sulphate proteoglycan, fibromodulin, has been isolated from pooled human articular cartilage. The main chain repeat region and the chain caps from the attached N-linked keratan sulphate chains have been fragmented by keratanase II digestion, and the oligosaccharides generated have been reduced and is...

journal_title：Glycoconjugate journal

authors： Lauder RM,Huckerby TN,Nieduszynski IA

更新日期：1997-08-01 00:00:00

abstract：:Our recent studies have revealed the existence of two distinct Gal: 3-O-sulfotransferases capable of acting on the C-3 position of galactose in a Core 2 branched structure, e.g., Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNacalph a1-->OBenzyl as acceptor to give 3-O-sulfoGalbeta1-->4GlcNAcbeta1-->3(Galbeta1-->3)G alN...

journal_title：Glycoconjugate journal

authors： Jain RK,Piskorz CF,Chandrasekaran EV,Matta KL

更新日期：1998-10-01 00:00:00

abstract：:Twenty different human and animal tissues were investigated for the presence of polyglycosylceramides. The glycolipids were isolated by peracetylation of dry tissue residues left after conventional lipid extraction, followed by extraction with chloroform and subsequent Sephadex LH-20, Sephadex LH-60 and silica gel chr...

journal_title：Glycoconjugate journal

authors： Miller-Podraza H,Stenhagen G,Larsson T,Andersson C,Karlsson KA

更新日期：1997-02-01 00:00:00

abstract：:O-Glycopyranosyl-N-hydroxysuccinimides of glucose and lactose have been synthesized. Peracetylated sugars, acetobromo sugars and benzoylated thioethyl glycosides have been used as precursors. With boron trifluoride etherate in dichloromethane, peracetylated sugars gave predominantly the beta anomer. Trimethylsilyl tri...

journal_title：Glycoconjugate journal

authors： Andersson M,Oscarson S

更新日期：1992-06-01 00:00:00

abstract：:Reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo) with allylamine (AIIN) or 2-(4-aminophenyl)ethylamine (APEA) yields epimer pairs of 2-N-allylamino and 2-N-[2-(4-aminophenyl)ethylamino]-2,3-dideoxy-D-glycero-D-galacto- and -2,3-dideoxy-D-glycero-D-talo-octonic acid. The yields were 50-60% due to reduction...

journal_title：Glycoconjugate journal

authors： Grimmecke HD,Brade H

更新日期：1998-06-01 00:00:00

abstract：:Cell surface lipopolysaccharide (LPS) is a well characterized virulence determinant for the human pathogen Haemophilus influenzae, so an investigation of LPS in the less pathogenic Haemophilus parainfluenzae could yield important insights. Using a panel of 18 commensal H. parainfluenzae isolates we demonstrate that th...

journal_title：Glycoconjugate journal

authors： Young RE,Hood DW

更新日期：2013-08-01 00:00:00

abstract：:A novel cold-water-soluble polysaccharide (BEP), with a molecular weight of 6.0 × 106 Da, was isolated from Boletus edulis. BEP consists of galactose, glucose, xylose, mannose, glucuronic, and galacturonic acid in a ratio of 0.34:0.28:0.28:2.57:1.00:0.44. The IR results showed that BEP was an acid polysaccharide, cont...

journal_title：Glycoconjugate journal

authors： Meng T,Yu SS,Ji HY,Xu XM,Liu AJ

更新日期：2021-01-28 00:00:00

abstract：:To elucidate the biological significance of the lactosylceramide (LacCer) branching in glycosphingolipid (GSL) biosynthesis, we established ganglioside GM3- and lactosylsulfatide SM3-reconstituted cells by introducing the GM3 synthase gene and the sulfotransferase gene, respectively. In SM3-expressing cells, the reduc...

journal_title：Glycoconjugate journal

authors： Inokuchi J,Kabayama K,Uemura S,Igarashi Y

更新日期：2004-01-01 00:00:00

abstract：:Heterologous complementation in yeast has been a successful tool for cloning and characterisation of genes from various organisms. Therefore we constructed conditionally lethal Saccharomyces cerevisiae strains by replacing the endogenous promoter from the genes of interest (glycosyltransferases) by the stringently reg...

journal_title：Glycoconjugate journal

authors： Mazhari-Tabrizi R,Blank M,Mumberg D,Funk M,Schwarz RT,Eckert V

更新日期：1999-11-01 00:00:00

abstract：:Transmembrane signaling requires modular interactions between signaling proteins, phosphorylation or dephosphorylation of the interacting protein partners and temporary elaboration of supramolecular structures, to convey the molecular information from the cell surface to the nucleus. Such signaling complexes at the pl...

journal_title：Glycoconjugate journal

authors： Hoessli DC,Ilangumaran S,Soltermann A,Robinson PJ,Borisch B,Nasir-Ud-Din

更新日期：2000-03-01 00:00:00

abstract：:Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens o...

journal_title：Glycoconjugate journal

authors： Nakamura Y,Miyata Y,Matsuo T,Shida Y,Hakariya T,Ohba K,Taima T,Ito A,Suda T,Hakomori SI,Saito S,Sakai H

更新日期：2019-10-01 00:00:00

abstract：:Over the last few years enormous interest has been shown in the structures of the glycan moieties of various parasite surface glycoconjugates. Structures have been determined for the glyco-components of glycosylphosphatidylinositol (GPI) protein membrane anchors, for asparagine-linked oligosaccharides, and for the gly...

journal_title：Glycoconjugate journal

authors： Zamze S

更新日期：1991-12-01 00:00:00

abstract：:Matrix proteoglycans (PGs) have shown promise as biomarker in malignancies. We employed agarose gel eletrophoresis, quantitative real- time reverse transcription-polymerase chain reaction and immunohistochemistry to evaluate the content of sulfated glicosaminoglycans (chondroitin sulfate and heparan sulfate) and expre...

journal_title：Glycoconjugate journal

authors： Rangel MP,de Sá VK,Prieto T,Martins JRM,Olivieri ER,Carraro D,Takagaki T,Capelozzi VL

更新日期：2018-04-01 00:00:00

abstract：:A straight forward synthesis of a heptasaccharide part of the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990, known to have antigenicity, has been achieved in excellent yield. Judicious choice of protecting groups in the intermediates played a significant role throughout the synthesis. Most of the i...

journal_title：Glycoconjugate journal

authors： Panchadhayee R,Kumar Misra A

更新日期：2008-12-01 00:00:00

abstract：:Rotaviruses are the leading cause of childhood diarrhea. The entry of rotaviruses into the host cell is a complex process that includes several interactions of the outer layer proteins of the virus with different cell surface molecules. The fact that neuraminidase treatment of the cells, or preincubation of the virus ...

journal_title：Glycoconjugate journal

authors： Isa P,Arias CF,López S

更新日期：2006-02-01 00:00:00

abstract：:Using a focused glycan-gene microarray, we compared the glycosyltransferase (GT) and sulfotransferase gene expression profiles of human monocytes, dendritic cells (DCs) and macrophages (Mphis), isolated or differentiated from the same donors. Microarray analysis indicated that monocytes express transcripts for a full ...

journal_title：Glycoconjugate journal

authors： Trottein F,Schaffer L,Ivanov S,Paget C,Vendeville C,Cazet A,Groux-Degroote S,Lee S,Krzewinski-Recchi MA,Faveeuw C,Head SR,Gosset P,Delannoy P

更新日期：2009-12-01 00:00:00

abstract：:N-acetylglucosaminyltransferase (GnT)-IV a is a key enzyme that catalyzes the formation of the GlcNAC β1-4 branch on the core structure of complex N-Glycans, which is the common substrate for other N-acetylglucosaminyltransferases, such as GnT-III and GnT-V. Our recent study indicates that the expression of GnT-IVa in...

journal_title：Glycoconjugate journal

authors： Fan J,Wang S,Yu S,He J,Zheng W,Zhang J

更新日期：2012-08-01 00:00:00

abstract：:Since the alpha-D-galactose-(1-->3)-D-galactose epitope has been identified to be the major target in the process of hyperacute rejection of xenografts transplanted from nonprimate donors to humans, specific inhibitors of alpha-galactosyltransferases are of broad interest. Using Trypanosoma brucei, a protozoan parasit...

journal_title：Glycoconjugate journal

authors： Kolb V,Amann F,Schmidt RR,Duszenko M

更新日期：1999-09-01 00:00:00

abstract：:UDP-GlcNAc:Man alpha 1-3R beta 1-2-N-acetylglucosaminyltransferase I (GlcNAc-T I; EC 2.4.1.101) catalyses the conversion of [Man alpha 1-6(Man alpha 1-3)Man alpha 1-6][Man alpha 1-3]Man beta-O-R to [Man alpha 1-6(Man alpha 1-3)Man alpha 1-6] [GlcNAc beta 1-2Man alpha 1-3]Man beta-O-R (R = 1-4GlcNAc beta 1-4GlcNAc- Asn...

journal_title：Glycoconjugate journal

authors： Reck F,Springer M,Meinjohanns E,Paulsen H,Brockhausen I,Schachter H

更新日期：1995-12-01 00:00:00