Bipolar depression: relationship between episode length and antidepressant treatment.

Abstract:

BACKGROUND:The role of antidepressant medications in bipolar depression remains controversial, mainly due to a lack of research in this area. In this study the authors examined the episode length in bipolar depression and the relationship between antidepressant therapy and episode length. METHOD:A retrospective chart review of 165 subjects identified 50 (30%) with bipolar illness who experienced a major depressive episode between 1 January 1998 and 15 December 2000. Data gathered utilized a structured instrument completed by the clinician at each visit. This instrument includes modified SCID mood modules as well as continuous ratings for each associated symptom of depression and mood elevation. Survival analysis was employed to calculate the median length of the depressive episodes for the entire group. Further survival analysis compared the episode length for subjects treated with antidepressants during the depression (N = 33) with those who did not receive antidepressants (N = 17). The rate of switch into elevated mood states was compared for the two groups. RESULTS:The survival analysis for the entire sample demonstrated 25%, 50% and 75% probability of recovery at 33 (S.E. 8.7), 66 (S.E. 17.9) and 215 (S.E. 109.9) days, respectively. Comparing those who received (N = 33) and those who did not receive (N = 17) antidepressants during the episode did not reveal any difference in the length of the depressive episode. Switch rates were not significantly different between those receiving antidepressants and those not taking these medications (15.2% v. 17.6%, respectively). CONCLUSIONS:Over the past 20 years little progress has been made in reducing the length of depressive episodes in those with bipolar illness. This is despite increasing pharmacological options available for treating depression. Clinicians treating bipolar depression should discuss with their patients the likelihood that the episode will last between 2-3 months. Our results also suggest that antidepressant treatment may not reduce the length of depressive episodes, neither did it appear to contribute to affective switch in our sample.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Frankle WG,Perlis RH,Deckersbach T,Grandin LD,Gray SM,Sachs GS,Nierenberg AA

doi

10.1017/s0033291702006165

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

1417-23

issue

8

eissn

0033-2917

issn

1469-8978

journal_volume

32

pub_type

杂志文章
  • Cognitive deficits in unipolar old-age depression: a population-based study.

    abstract:BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713001736

    authors: Pantzar A,Laukka EJ,Atti AR,Fastbom J,Fratiglioni L,Bäckman L

    更新日期:2014-04-01 00:00:00

  • Emotional distress and satisfaction in life among Holocaust survivors--a community study of survivors and controls.

    abstract::Results are reported from a large population study (of working people) comparing Holocaust survivors and a control group in regard to emotional distress, satisfaction in life and psychosomatic symptoms. It was found that, even 40 years after the traumatic experience, this group of survivors exhibited a slightly higher...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700002580

    authors: Carmil D,Carel RS

    更新日期:1986-02-01 00:00:00

  • Language and dementia: a review.

    abstract::In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the languag...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700001938

    authors: Hart S

    更新日期:1988-02-01 00:00:00

  • Brain activation during emotion regulation in women with premenstrual dysphoric disorder.

    abstract:BACKGROUND:Difficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD. METHODS:On the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717003270

    authors: Petersen N,Ghahremani DG,Rapkin AJ,Berman SM,Liang L,London ED

    更新日期:2018-08-01 00:00:00

  • The general practitioner as the first contacted health professional by patients with psychosocial problems: a European study.

    abstract:BACKGROUND:There are considerable differences between and within countries in the involvement of general practitioners (GPs) in psychosocial care. This study aimed to describe the self-perceived role of GPs in 30 European countries as the first contacted professional for patients with psychosocial problems. and to exam...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329179900851x

    authors: Boerma WG,Verhaak PF

    更新日期:1999-05-01 00:00:00

  • Neuropsychological function and suicidal behavior: attention control, memory and executive dysfunction in suicide attempt.

    abstract:BACKGROUND:Executive dysfunction, distinct from other cognitive deficits in depression, has been associated with suicidal behavior. However, this dysfunction is not found consistently across samples. METHOD:Medication-free subjects with DSM-IV major depressive episode (major depressive disorder and bipolar type I diso...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712001419

    authors: Keilp JG,Gorlyn M,Russell M,Oquendo MA,Burke AK,Harkavy-Friedman J,Mann JJ

    更新日期:2013-03-01 00:00:00

  • The causal nature of the association between resting pulse in late adolescence and risk for internalizing and externalizing disorders: a co-relative analysis in a national male Swedish sample.

    abstract:BACKGROUND:Resting pulse is robustly and inversely associated with the risk for externalizing disorders and may be positively associated with internalizing disorders. We know little about the causal nature of these associations. METHODS:We examined resting pulse at conscription examination in 369 301 males born 1960-8...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000549

    authors: Kendler KS,Lönn SL,Sundquist J,Sundquist K

    更新日期:2020-03-24 00:00:00

  • Shared and unique risk factors between lifetime purging and objective binge eating: a twin study.

    abstract:BACKGROUND:Objective binge eating (OBE) and self-induced vomiting (SIV) occur and co-occur across a range of eating disorders but the extent to which the risk factors for these two behaviours overlap is unclear. Examination of this overlap was the focus of the current report. METHOD:A population of female Australian t...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708002791

    authors: Wade TD,Treloar S,Martin NG

    更新日期:2008-10-01 00:00:00

  • Administrative incidence of psychosis assessed in an early intervention service in England: first epidemiological evidence from a diverse, rural and urban setting.

    abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291710002461

    authors: Cheng F,Kirkbride JB,Lennox BR,Perez J,Masson K,Lawrence K,Hill K,Feeley L,Painter M,Murray GK,Gallagher O,Bullmore ET,Jones PB

    更新日期:2011-05-01 00:00:00

  • The incidence and prevalence of pervasive developmental disorders: a Danish population-based study.

    abstract:BACKGROUND:Based on prevalence studies and the few incidence studies of pervasive developmental disorders (PDDs) the prevalence and incidence of these disorders have been claimed to be increasing. METHOD:The annual and age-specific prevalence and incidence rates of childhood autism, atypical autism, Asperger's disorde...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704002387

    authors: Lauritsen MB,Pedersen CB,Mortensen PB

    更新日期:2004-10-01 00:00:00

  • Marriage, motherhood and psychiatric morbidity in New Zealand.

    abstract::The prevalence of psychiatric disorder, as assessed by both the GHQ-28 and the short PSE, is described for a random community sample of New Zealand women. In contrast to previous studies, married and widowed women and mothers showed lower rates than the never married and childless women. A plausible explanation is pro...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700009909

    authors: Romans-Clarkson SE,Walton VA,Herbison GP,Mullen PE

    更新日期:1988-11-01 00:00:00

  • The association of sexual and physical abuse with somatization: characteristics of patients presenting with irritable bowel syndrome and non-epileptic attack disorder.

    abstract:BACKGROUND:Physical symptoms are commonly presented for treatment in the absence of physical pathology. This study tests predictions arising from the theory that childhood sexual abuse leads to emotional distress, illness orientation and social dysfunction as adults and that one or more of these effects, in turn, leads...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291798007892

    authors: Reilly J,Baker GA,Rhodes J,Salmon P

    更新日期:1999-03-01 00:00:00

  • Posttraumatic stress disorder symptom trajectories within the first year following emergency department admissions: pooled results from the International Consortium to predict PTSD.

    abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719004008

    authors: Lowe SR,Ratanatharathorn A,Lai BS,van der Mei W,Barbano AC,Bryant RA,Delahanty DL,Matsuoka YJ,Olff M,Schnyder U,Laska E,Koenen KC,Shalev AY,Kessler RC

    更新日期:2020-02-03 00:00:00

  • Oral contraceptive use and risk of suicidal behavior among young women.

    abstract:BACKGROUND:Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. METHODS:We used Swedish national registries to identify wom...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003475

    authors: Edwards AC,Lönn SL,Crump C,Mościcki EK,Sundquist J,Kendler KS,Sundquist K

    更新日期:2020-10-21 00:00:00

  • Variations in referral pattern to the psychiatric services by general practitioners.

    abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700030865

    authors: Robertson NC

    更新日期:1979-05-01 00:00:00

  • Emotional factors in forgetting.

    abstract::Levinger & Clarke (1961) found that subjects tended to forget more word associations to emotional rather than neutral words. Kline (1981) regarded this study as providing 'irrefutable evidence for the Freudian concept of repression'. On the other hand, results from Kleinsmith & Kaplan (1964) suggested that this effect...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700017669

    authors: Bradley BP,Baddeley AD

    更新日期:1990-05-01 00:00:00

  • Multivariate predictors of social skills performance in middle-aged and older out-patients with schizophrenia spectrum disorders.

    abstract:BACKGROUND:Cognitive impairment and negative symptoms are two of the primary features of schizophrenia associated with poor social functioning. We examined the relationships between clinical characteristics, specific cognitive abilities and social skills performance in middle-aged and older out-patients with schizophre...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707001304

    authors: Sitzer DI,Twamley EW,Patterson TL,Jeste DV

    更新日期:2008-05-01 00:00:00

  • Time, memory and the heritability of major depression.

    abstract:OBJECTIVE:Although family, twin and adoption studies have suggested that lifetime major depression (MD) is a heritable condition, nearly all these studies have relied for the diagnosis on long-term human memory, which is fallible and potentially biased. Could the estimates of heritability of MD be biased by the well-de...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701003695

    authors: Kendler KS,Aggen SH

    更新日期:2001-07-01 00:00:00

  • The influence of the economic and social environment on deliberate self-harm and suicide: an ecological and person-based study.

    abstract:BACKGROUND:Geographic variations in the incidence of deliberate self-harm (DSH) and suicide have been shown to be associated with area-based measures of socio-economic deprivation and social fragmentation. Previous studies have been subject to methodological limitations. None has investigated whether ecological associa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701003993

    authors: Hawton K,Harriss L,Hodder K,Simkin S,Gunnell D

    更新日期:2001-07-01 00:00:00

  • Negative self-evaluation and the genesis of internal threat: beyond a continuum of suicidal thought and behaviour.

    abstract:BACKGROUND:Death by suicide is often preceded by attempted suicide, suicidal ideation and non-suicidal self-injury. These extreme thoughts and behaviours have been considered in terms of a continuum of suicidality. Little known research, however, has considered a suicide continuum that extends beyond these extreme thou...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718003562

    authors: Butter S,Shevlin M,Murphy J

    更新日期:2019-11-01 00:00:00

  • The stability of the factor structure of the General Health Questionnaire.

    abstract:BACKGROUND:Different versions of the General Health Questionnaire (GHQ), including the GHQ-12 and GHQ-28 have been subjected to factor analysis in a variety of countries. The World Health Organization study of psychological disorders in general health care offered the opportunity to investigate the factor structure of ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s0033291799002287

    authors: Werneke U,Goldberg DP,Yalcin I,Ustün BT

    更新日期:2000-07-01 00:00:00

  • Depression, smoking, and lung cancer risk over 24 years among women.

    abstract:BACKGROUND:Studies evaluating depression's role in lung cancer risk revealed contradictory findings, partly because of the small number of cases, short follow-up periods, and failure to account for key covariates including smoking exposure. We investigated the association of depressive symptoms with lung cancer risk in...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004390

    authors: Trudel-Fitzgerald C,Zevon ES,Kawachi I,Tucker-Seeley RD,Kubzansky LD

    更新日期:2020-12-03 00:00:00

  • Risk factors for physical symptoms after a disaster: a longitudinal study.

    abstract:BACKGROUND:Although symptoms such as fatigue, headache and pain in bones and muscles are common after disasters, risk factors for these symptoms among disaster survivors have rarely been studied. We examined predisposing, precipitating and perpetuating factors for these physical symptoms among survivors of a man-made d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170700133X

    authors: van den Berg B,Grievink L,van der Velden PG,Yzermans CJ,Stellato RK,Lebret E,Brunekreef B

    更新日期:2008-04-01 00:00:00

  • Comparison of psychotherapies for adult depression to pill placebo control groups: a meta-analysis.

    abstract:BACKGROUND:The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advanta...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0033291713000457

    authors: Cuijpers P,Turner EH,Mohr DC,Hofmann SG,Andersson G,Berking M,Coyne J

    更新日期:2014-03-01 00:00:00

  • Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.

    abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715001609

    authors: Noda Y,Silverstein WK,Barr MS,Vila-Rodriguez F,Downar J,Rajji TK,Fitzgerald PB,Mulsant BH,Vigod SN,Daskalakis ZJ,Blumberger DM

    更新日期:2015-12-01 00:00:00

  • Transdiagnostic dimensions in obsessive-compulsive and related disorders: associations with internalizing and externalizing symptoms.

    abstract:BACKGROUND:Hierarchical structural models of psychopathology rarely extend to obsessive-compulsive spectrum disorders. The current study sought to examine the higher-order structure of the obsessive-compulsive and related disorders (OCRDs) in DSM-5: obsessive-compulsive disorder (OCD), hoarding disorder (HD), body dysm...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000380

    authors: Snorrason I,Beard C,Peckham AD,Björgvinsson T

    更新日期:2020-03-06 00:00:00

  • Non-suicidal self-injury prevalence, course, and association with suicidal thoughts and behaviors in two large, representative samples of US Army soldiers.

    abstract:BACKGROUND:Non-suicidal self-injury (NSSI) prospectively predicts suicidal thoughts and behaviors in civilian populations. Despite high rates of suicide among US military members, little is known about the prevalence and course of NSSI, or how NSSI relates to suicidal thoughts and behaviors, in military personnel. MET...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718002015

    authors: Turner BJ,Kleiman EM,Nock MK

    更新日期:2019-07-01 00:00:00

  • The cross-national epidemiology of specific phobia in the World Mental Health Surveys.

    abstract:BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717000174

    authors: Wardenaar KJ,Lim CCW,Al-Hamzawi AO,Alonso J,Andrade LH,Benjet C,Bunting B,de Girolamo G,Demyttenaere K,Florescu SE,Gureje O,Hisateru T,Hu C,Huang Y,Karam E,Kiejna A,Lepine JP,Navarro-Mateu F,Oakley Browne M,Piazza M

    更新日期:2017-07-01 00:00:00

  • A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group.

    abstract:BACKGROUND:The usefulness of any diagnostic scheme is directly related to its ability to provide clinically useful information on need for care. In this study, the clinical usefulness of dimensional and categorical representations of psychotic psychopathology were compared. METHOD:A total of 706 patients aged 16-65 ye...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291798008162

    authors: Van Os J,Gilvarry C,Bale R,Van Horn E,Tattan T,White I,Murray R

    更新日期:1999-05-01 00:00:00

  • Fronto-thalamic structural and effective connectivity and delusions in schizophrenia: a combined DTI/DCM study.

    abstract:BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000859

    authors: Csukly G,Szabó Á,Polgár P,Farkas K,Gyebnár G,Kozák LR,Stefanics G

    更新日期:2020-04-24 00:00:00