Multiplication of parvovirus LuIII in a synchronized culture system. III. Replication of viral DNA.

abstract：:The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated in Guangxi and Hong Kong, China. Genetic and epidemiological analyses suggest that these viruses have circulated in sw...

journal_title：Journal of virology

authors： Fan X,Zhu H,Zhou B,Smith DK,Chen X,Lam TT,Poon LL,Peiris M,Guan Y

更新日期：2012-02-01 00:00:00

abstract：UNLABELLED:Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to increase viral mutation rates and burden viral populations with mutations that reduce the number of infectious progeny. We inv...

journal_title：Journal of virology

authors： Pauly MD,Lauring AS

更新日期：2015-04-01 00:00:00

abstract：:The NS5A nonstructural protein of hepatitis C virus (HCV) has been shown to inhibit the cellular interferon (IFN)-induced protein kinase R (PKR). PKR mediates the host IFN-induced antiviral response at least in part by inhibiting mRNA translation initiation through phosphorylation of the alpha subunit of eukaryotic in...

journal_title：Journal of virology

authors： He Y,Tan SL,Tareen SU,Vijaysri S,Langland JO,Jacobs BL,Katze MG

更新日期：2001-06-01 00:00:00

abstract：:The in vitro transcription of the genome segments of insect cytoplasmic polyhedrosis virus was examined for a possible mechanism of coordinate control. Initiation of the first transcription cycle, primed by preincubation in the absence of CTP, was synchronous for all 10 viral genome segments. The time required for the...

journal_title：Journal of virology

authors： Smith RE,Furuichi Y

更新日期：1982-01-01 00:00:00

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-specific T-cell lines generated by repeated stimulation with EBV-immortalized lymphoblastoid B-cell lines (LCL) have been successfully used to treat EBV-associated posttransplant lymphoproliferative disease (PTLD) in hematopoietic stem cell transplant recipients. However, PTLD in solid-organ t...

journal_title：Journal of virology

authors： Adhikary D,Behrends U,Feederle R,Delecluse HJ,Mautner J

更新日期：2008-04-01 00:00:00

abstract：:Human CD317 (BST-2/tetherin) is an intrinsic immunity factor that blocks the release of retroviruses, filoviruses, herpesviruses, and arenaviruses. It is unclear whether CD317 expressed endogenously in rodent cells has the capacity to interfere with the replication of the retroviral rodent pathogen murine leukemia vir...

journal_title：Journal of virology

authors： Goffinet C,Schmidt S,Kern C,Oberbremer L,Keppler OT

更新日期：2010-11-01 00:00:00

abstract：:The complex evolutionary process of human immunodeficiency virus type 1 (HIV-1) is marked by a high level of genetic variation. It has been shown that the HIV-1 genome is characterized by variable and more constant regions, unequal nucleotide frequencies, and preference for G-to-A substitutions. However, this knowledg...

journal_title：Journal of virology

authors： Leitner T,Kumar S,Albert J

更新日期：1997-06-01 00:00:00

abstract：:The pathway of envelopment and egress of the varicella-zoster virus (VZV) and the primary site of viral production within the epidermal layer of the skin are not fully understood. There are several hypotheses to explain how the virus may receive an envelope as it travels to the surface of the monolayer. In this study,...

journal_title：Journal of virology

authors： Harson R,Grose C

更新日期：1995-08-01 00:00:00

abstract：:The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nef-attenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show that viral phenotypes and antibody responses differ considerably between individual cohort members, despite the single ...

journal_title：Journal of virology

authors： Verity EE,Zotos D,Wilson K,Chatfield C,Lawson VA,Dwyer DE,Cunningham A,Learmont J,Dyer W,Sullivan J,Churchill M,Wesselingh SL,Gabuzda D,Gorry PR,McPhee DA

更新日期：2007-09-01 00:00:00

abstract：:The expression of reporter genes driven by the same human elongation factor 1alpha (EF1alpha) promoter in murine leukemia virus (MLV)- and human immunodeficiency virus type 1 (HIV-1)-based vectors was studied in either transfected or virally transduced cells. The HIV-1 vectors consistently expressed 3 to 10 times high...

journal_title：Journal of virology

authors： Zaiss AK,Son S,Chang LJ

更新日期：2002-07-01 00:00:00

abstract：:How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating i...

journal_title：Journal of virology

authors： Trifilo MJ,Montalto-Morrison C,Stiles LN,Hurst KR,Hardison JL,Manning JE,Masters PS,Lane TE

更新日期：2004-01-01 00:00:00

abstract：:Influenza A viruses (IAVs) are viral pathogens that cause epidemics and occasional pandemics of significant mortality. The generation of efficacious vaccines and antiviral drugs remains a challenge due to the rapid appearance of new influenza virus types and antigenic variants. Consequently, novel strategies for the p...

journal_title：Journal of virology

authors： Jiang M,Österlund P,Westenius V,Guo D,Poranen MM,Bamford DH,Julkunen I

更新日期：2019-02-05 00:00:00

abstract：:We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection. ...

journal_title：Journal of virology

authors： Weinberg JB,Lutzke ML,Efstathiou S,Kunkel SL,Rochford R

更新日期：2002-10-01 00:00:00

abstract：:Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, respectively. After resolution of the primary disease, SVV and VZV establish latent infection of neural ganglia and may later reactivate to cause a sec...

journal_title：Journal of virology

authors： Ou Y,Davis KA,Traina-Dorge V,Gray WL

更新日期：2007-08-01 00:00:00

abstract：:Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the core protein, is important for the production of cell culture-infectious virus (HCVcc). Ala...

journal_title：Journal of virology

authors： Angus AG,Loquet A,Stack SJ,Dalrymple D,Gatherer D,Penin F,Patel AH

更新日期：2012-01-01 00:00:00

abstract：:Koi herpesvirus (KHV) is the causative agent of a lethal disease in koi and common carp. In the present study, we describe the cloning of the KHV genome as a stable and infectious bacterial artificial chromosome (BAC) clone that can be used to produce KHV recombinant strains. This goal was achieved by the insertion of...

journal_title：Journal of virology

authors： Costes B,Fournier G,Michel B,Delforge C,Raj VS,Dewals B,Gillet L,Drion P,Body A,Schynts F,Lieffrig F,Vanderplasschen A

更新日期：2008-05-01 00:00:00

abstract：:Live attenuated human immunodeficiency virus type 1 (HIV-1) vaccines are considered unsafe because faster-replicating pathogenic virus variants may evolve after vaccination. We previously presented a conditional-live HIV-1 variant of which replication can be switched off as an alternative vaccination strategy. To impr...

journal_title：Journal of virology

authors： Das AT,Baldwin CE,Vink M,Berkhout B

更新日期：2005-03-01 00:00:00

abstract：:Measles virus (MV) can infect the central nervous system and, in rare cases, causes subacute sclerosing panencephalitis, characterized by a progressive degeneration of neurons. The route of MV transmission in neurons was investigated in cultured rat hippocampal slices by using MV expressing green fluorescent protein. ...

journal_title：Journal of virology

authors： Ehrengruber MU,Ehler E,Billeter MA,Naim HY

更新日期：2002-06-01 00:00:00

abstract：:We have analyzed the effects of reducing conditions on the folding of the spike (S) protein and on the intracellular transport of the membrane (M) protein of the mouse hepatitis coronavirus. These proteins differ in their potential to form disulfide bonds in the lumen of the endoplasmic reticulum (ER). Intrachain disu...

journal_title：Journal of virology

authors： Opstelten DJ,de Groote P,Horzinek MC,Vennema H,Rottier PJ

更新日期：1993-12-01 00:00:00

abstract：UNLABELLED:Antibodies against the fusion (F) protein of respiratory syncytial virus (RSV) play an important role in the protective immune response to this important respiratory virus. Little is known, however, about antibody levels against multiple F-specific epitopes induced by infection or after vaccination against R...

journal_title：Journal of virology

authors： Widjaja I,Wicht O,Luytjes W,Leenhouts K,Rottier PJM,van Kuppeveld FJM,Haijema BJ,de Haan CAM

更新日期：2016-06-10 00:00:00

abstract：:Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no longer replicate. However, certain human tumor cell lines have been show...

journal_title：Journal of virology

authors： Contreras-Galindo R,Kaplan MH,Leissner P,Verjat T,Ferlenghi I,Bagnoli F,Giusti F,Dosik MH,Hayes DF,Gitlin SD,Markovitz DM

更新日期：2008-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is one of five viral nuclear proteins that are essential for EBV-induced immortalization of primary human B lymphocytes in vitro. Previous studies have implied that EBNA-3C acts as a transcription factor. Using transient transfection assays, we demonstrate that EBN...

journal_title：Journal of virology

authors： Marshall D,Sample C

更新日期：1995-06-01 00:00:00

abstract：:Recently, novel arenaviruses were found in snakes with boid inclusion body disease (BIBD); these form the new genus Reptarenavirus within the family Arenaviridae. We used next-generation sequencing and de novo sequence assembly to investigate reptarenavirus isolates from our previous study. Four of the six isolates an...

journal_title：Journal of virology

authors： Hepojoki J,Salmenperä P,Sironen T,Hetzel U,Korzyukov Y,Kipar A,Vapalahti O

更新日期：2015-08-01 00:00:00

abstract：:Live attenuated RNA viruses make highly efficient vaccines. Among them, measles virus (MV) vaccine has been given to a very large number of children and has been shown to be highly efficacious and safe. Therefore, this vaccine might be a very promising vector to immunize children against both measles and other infecti...

journal_title：Journal of virology

authors： Combredet C,Labrousse V,Mollet L,Lorin C,Delebecque F,Hurtrel B,McClure H,Feinberg MB,Brahic M,Tangy F

更新日期：2003-11-01 00:00:00

abstract：:The role of autoimmunity in large-vessel vasculitis in humans remains unclear. We have previously shown that infection of gamma interferon receptor knockout (IFN-gamma R(-/-)) mice with gammaherpesvirus 68 (gamma HV68) results in severe inflammation of the large elastic arteries that is pathologically similar to the l...

journal_title：Journal of virology

authors： Dal Canto AJ,Virgin HW 4th,Speck SH

更新日期：2000-12-01 00:00:00

abstract：:It has been shown that not all but most of the avian influenza viruses replicate in the upper respiratory tract of pigs (H. Kida et al., J. Gen. Virol. 75:2183-2188, 1994). It was shown that A/chicken/Yamaguchi/7/2004 (H5N1) [Ck/Yamaguchi/04 (H5N1)] did not replicate in pigs (N. Isoda et al., Arch. Virol. 151:1267-127...

journal_title：Journal of virology

authors： Manzoor R,Sakoda Y,Nomura N,Tsuda Y,Ozaki H,Okamatsu M,Kida H

更新日期：2009-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection remains a major worldwide health problem despite development of highly effective direct-acting antivirals. HCV rapidly evolves upon acute infection and generates multiple viral variants (quasispecies), leading to immune evasion and persistent viral infection. Identification of epitope...

journal_title：Journal of virology

authors： Tong Y,Li Q,Li R,Xu Y,Pan Y,Niu J,Zhong J

更新日期：2020-08-17 00:00:00

abstract：:Glycoprotein H (gH) is conserved among all herpesviruses and is essential for virus entry and cell fusion along with gL, gB, and, in most alphaherpesviruses, gD. Within the gH/gL heterodimer, it is thought that gH accounts for the fusion function and gL acts as a chaperone for the folding and transport of gH. Here, we...

journal_title：Journal of virology

authors： Cairns TM,Friedman LS,Lou H,Whitbeck JC,Shaner MS,Cohen GH,Eisenberg RJ

更新日期：2007-05-01 00:00:00

abstract：:Examination of [3H]mannose-labeled glycopeptides from Prague C Rous sarcoma virus gp85 with gel filtration and sequential glycosidase digestions demonstrated the presence of hybrid-type asparaginyl-oligosaccharides. The major hybrid species had an oligomannosyl core (Man5GlcNAc2-ASN) characteristic of neutral structur...

journal_title：Journal of virology

authors： Hunt LA,Wright SE

更新日期：1981-08-01 00:00:00