Abstract:
:The specificity of self MHC-restricted T cells responding to peptide fragments of processed antigen has been well characterized. However, the means by which alloreactive T lymphocytes recognize MHC alloantigen remain poorly understood. We now provide evidence that the recognition of class I human leukocyte antigen (HLA) alloantigen by alloreactive cytotoxic T lymphocytes (CTL) induced in primary mixed lymphocyte cultures is class I HLA-restricted to a great extent. This is shown by the 'split-well' limiting dilution assay using third party target cells bearing a stimulating class I HLA alloantigen either in (i) the presence or (ii) the absence of class I HLA antigen(s) which is shared with the responder. Alloreactive CTL were found which recognize stimulator class I HLA alloantigen on the first but not on the second type of target cells. The results show that, in contrast to the traditional view, a large proportion of the alloreactive CTL against class I HLA alloantigen generated in primary mixed lymphocyte cultures is self class I HLA-restricted.
journal_name
Int Immunoljournal_title
International immunologyauthors
Breur-Vriesendorp BS,Ivanyi Pdoi
10.1093/intimm/5.1.103subject
Has Abstractpub_date
1993-01-01 00:00:00pages
103-7issue
1eissn
0953-8178issn
1460-2377journal_volume
5pub_type
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.11.1687
更新日期:1997-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.12.1501
更新日期:1993-12-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxn024
更新日期:2008-05-01 00:00:00
abstract::Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.1.21
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
abstract::The MHC class I antigens enhance the T cell response to various mitogenic stimuli. Class I antigens co-cap and associate with the CD3 structure on these cells. The present work shows that co-aggregation of these MHC antigens with CD3 induces a sustained elevated Ca2+ response in T cells. The duration required for a 50...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.3.481
更新日期:1994-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh233
更新日期:2005-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.10.1585
更新日期:1994-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.11.1263
更新日期:1992-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/14.1.39
更新日期:2002-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxv068
更新日期:2016-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.2.251
更新日期:1995-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxp066
更新日期:2009-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/13.1.13
更新日期:2001-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf079
更新日期:2002-10-01 00:00:00
abstract::We developed a novel approach to probe the molecular basis of TCR recognition of the MHC class I-peptide complex and to determine how constraints placed on peptide binding by the class I molecule influence T cell recognition. We synthesized peptide pairs derived from the N- and C-terminal regions of class I peptide li...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.1.81
更新日期:1997-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxr123
更新日期:2012-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh024
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/9.8.1131
更新日期:1997-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/13.12.1489
更新日期:2001-12-01 00:00:00
abstract::T cell responses against complex antigens are often directed against a limited set of immunodominant determinants. We have studied this phenomenon at the level of cellularly processed peptides recognized by CTL in the B6 anti-BALB.B minor histocompatibility (H) barrier, comprising at least 29 antigen loci. B6 anti-BAL...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.6.919
更新日期:1995-06-01 00:00:00
abstract::p40 was previously described as a regulatory molecule capable of inhibiting both the natural and the CD16-mediated cytotoxicity of NK cells. In this study, we analyze the effect of p40 molecule engagement on the NK cell triggering induced by activating HLA class I-specific NK receptors (NKR) or on TCR alpha beta-media...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.9.1271
更新日期:1997-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.3.321
更新日期:1992-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.11.1777
更新日期:1994-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/2.12.1167
更新日期:1990-01-01 00:00:00