Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck study.

Abstract:

BACKGROUND AND PURPOSE:Accumulating evidence indicates that a variety of infections contribute to the pathogenesis of atherosclerosis, but there is controversy concerning the impact of Helicobacter pylori infections in atherosclerosis. METHODS:We evaluated seropositivity to H pylori and to its cytotoxin-associated gene A (CagA) product in a large, prospective, population-based study (n=684). Intima-media thickness and atherosclerosis of carotid arteries were thoroughly assessed by high-resolution duplex scanning. RESULTS:In our study population, H pylori infections defined by seropositivity have no relationship with levels of classic cardiovascular risk factors or markers of systemic inflammation, except for elevated levels of immune reactions to mycobacterial heat shock protein 65. The latter showed a trend toward highest levels in those harboring virulent H pylori strains (P=0.08). Common carotid artery intima-media thickness-both absolute values and changes between 1995 and 2000-were significantly enhanced in subjects seropositive to CagA but not in those infected with CagA-negative H pylori strains. There was a clear dose-response relation between anti-CagA antibodies and both intima-media thickness and atherosclerosis risk. Notably, the risk of atherosclerosis associated with CagA seropositivity was amplified by elevated C-reactive protein levels. CONCLUSIONS:Infections with virulent CagA-bearing H pylori strains may contribute to the pathogenesis of early atherosclerosis by aggravating immune-inflammatory reactions.

journal_name

Stroke

journal_title

Stroke

authors

Mayr M,Kiechl S,Mendall MA,Willeit J,Wick G,Xu Q

doi

10.1161/01.STR.0000058481.82639.EF

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

610-5

issue

3

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000058481.82639.EF

journal_volume

34

pub_type

杂志文章

相关文献

STROKE文献大全
  • Accuracy of ICD-9-CM coding for the identification of patients with acute ischemic stroke: effect of modifier codes.

    abstract:BACKGROUND AND PURPOSE:Discharge ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) codes have been used to identify patients with acute stroke for epidemiological, quality of care, and cost studies. The aim of this study was to determine if the accuracy of the primary ICD-9-CM cod...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.8.1602

    authors: Goldstein LB

    更新日期:1998-08-01 00:00:00

  • Reversed intracranial blood flow in patients with an intra-aortic balloon pump.

    abstract::As a preliminary investigation into the cerebral effects of mechanical cardiac assist devices, using transcranial Doppler ultrasonography I examined the basal cerebral arteries in three patients placed on an intra-aortic balloon pump. Unassisted systoles had normal blood velocities and waveforms. When the pump was in ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.3.484

    authors: Brass LM

    更新日期:1990-03-01 00:00:00

  • Variations in case fatality and dependency from stroke in western and central Europe. The European BIOMED Study of Stroke Care Group.

    abstract:BACKGROUND AND PURPOSE:There are significant variations in mortality rates from stroke in Europe. A European Union BIOMED Concerted Action was established to assess and determine the reasons for the variations in case fatality and disability after stroke. METHODS:Hospital-based stroke registers were established in 12 ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.str.30.2.350

    authors: Wolfe CD,Tilling K,Beech R,Rudd AG

    更新日期:1999-02-01 00:00:00

  • Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat.

    abstract:BACKGROUND AND PURPOSE:To identify if the stroke-prone spontaneously hypertensive rat (SHRSP) exhibits impaired functional recovery after stroke compared with its normotensive reference strain, the Wistar Kyoto rat (WKY). METHODS:In study 1, a 2-mm distal middle cerebral artery occlusion (middle cerebral artery occlus...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000149629.32525.b7

    authors: McGill JK,Gallagher L,Carswell HV,Irving EA,Dominiczak AF,Macrae IM

    更新日期:2005-01-01 00:00:00

  • Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.

    abstract:BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013204

    authors: Sung YF,Lu CC,Lee JT,Hung YJ,Hu CJ,Jeng JS,Chiou HY,Peng GS

    更新日期:2016-09-01 00:00:00

  • Transcranial Doppler.

    abstract::TCD recording of flow velocities in intracranial vessels was first described by Aaslid in 1982. The utility of this instrument becomes more apparent as it is used in different clinical settings and compared with angiographic findings (Figures 1 and 2). Its importance in early detection of vasospasm in subarachnoid hem...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.7.915

    authors: DeWitt LD,Wechsler LR

    更新日期:1988-07-01 00:00:00

  • Prevalence and causes of early-onset dementia in Japan: a population-based study.

    abstract:BACKGROUND AND PURPOSE:Few studies are available that have addressed the prevalence of early-onset dementia (EOD), including early-onset Alzheimer disease and other forms of dementia in Japan. METHODS:A 2-step postal survey was sent to all of the 2475 institutions providing medical or care services for individuals wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.542308

    authors: Ikejima C,Yasuno F,Mizukami K,Sasaki M,Tanimukai S,Asada T

    更新日期:2009-08-01 00:00:00

  • Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice.

    abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000204028.39783.d9

    authors: Moriwaki T,Takagi Y,Sadamasa N,Aoki T,Nozaki K,Hashimoto N

    更新日期:2006-03-01 00:00:00

  • Fibrinogen independently predicts the development of ischemic stroke in a Taiwanese population: CVDFACTS study.

    abstract:BACKGROUND AND PURPOSE:Of few prospective studies that have focused on the relationship between fibrinogen and ischemic stroke (IS) in Asian populations, the findings were inconsistent with those conducted in Western countries. Therefore, we aimed to investigate the temporal relationship between fibrinogen levels (plus...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.540492

    authors: Chuang SY,Bai CH,Chen WH,Lien LM,Pan WH

    更新日期:2009-05-01 00:00:00

  • Occurrence and clinical impact of microembolic signals during or after cardiosurgical procedures.

    abstract:BACKGROUND AND PURPOSE:Microembolic signals (MESs) are detectable within the transcranial Doppler frequency spectrum downstream from vascular atherothrombotic or cardiothrombotic lesions. A frequent occurrence of MESs has also been shown during bypass surgery or after mechanical valve implantation. We sought to compile...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.107.491241

    authors: Dittrich R,Ringelstein EB

    更新日期:2008-02-01 00:00:00

  • Predictors of time from hospital arrival to initial brain-imaging among suspected stroke patients: the North Carolina Collaborative Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:We examined patient demographic and hospital characteristics and clinical predictors of delay time from hospital arrival until CT among 20 374 patients enrolled in the North Carolina Collaborative Stroke Registry (January 2005 to April 2008). METHODS:Delay time was log-transformed in linear regr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.524686

    authors: Rose KM,Rosamond WD,Huston SL,Murphy CV,Tegeler CH

    更新日期:2008-12-01 00:00:00

  • Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in Finnish and Swedish cohorts.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to compare definitions of metabolic syndrome with regard to their prediction of stroke and coronary heart disease incidence. METHODS:The study comprises 4041 men and 3812 women of 6 Finnish and Swedish cohorts aged 25 to 74 years at baseline. Hazard ratio was estima...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.518878

    authors: Qiao Q,Laatikainen T,Zethelius B,Stegmayr B,Eliasson M,Jousilahti P,Tuomilehto J

    更新日期:2009-02-01 00:00:00

  • Blinded-reader comparison of magnetic resonance angiography and duplex ultrasonography for carotid artery bifurcation stenosis.

    abstract:BACKGROUND AND PURPOSE:We compared two-dimensional time-of-flight magnetic resonance angiography (MRA) and duplex ultrasonography with arteriography for the detection of 70% to 99% stenoses at the carotid artery bifurcation (ie, surgical disease according to findings of the North American Carotid Endarterectomy Trial)....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.1.4

    authors: Mittl RL Jr,Broderick M,Carpenter JP,Goldberg HI,Listerud J,Mishkin MM,Berkowitz HD,Atlas SW

    更新日期:1994-01-01 00:00:00

  • Role of potassium channels in cerebral blood vessels.

    abstract:BACKGROUND:Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium ch...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.26.9.1713

    authors: Kitazono T,Faraci FM,Taguchi H,Heistad DD

    更新日期:1995-09-01 00:00:00

  • Incidence of aneurysmal subarachnoid hemorrhage in Shimokita, Japan, from 1989 to 1998.

    abstract:BACKGROUND AND PURPOSE:The incidence of subarachnoid hemorrhage (SAH) has been investigated in many studies. A recent study in Izumo, Japan, indicates that the incidence of SAH is as high as that in Finland. The purpose of this study was to confirm the high incidence of SAH in Japan. METHODS:The incidence rate of SAH ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0102.101891

    authors: Ohkuma H,Fujita S,Suzuki S

    更新日期:2002-01-01 00:00:00

  • IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke.

    abstract:BACKGROUND AND PURPOSE:Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are established mediators of tissue damage in stroke, and the role of dendritic cells (DCs) in inducing the early events of T cell activation and differentiati...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019101

    authors: Gelderblom M,Gallizioli M,Ludewig P,Thom V,Arunachalam P,Rissiek B,Bernreuther C,Glatzel M,Korn T,Arumugam TV,Sedlacik J,Gerloff C,Tolosa E,Planas AM,Magnus T

    更新日期:2018-01-01 00:00:00

  • Deferral of Consent in Acute Stroke Trials.

    abstract::Background and Purpose- The ESCAPE trial (The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times) was a multicentre, randomized controlled trial of endovascular thrombectomy versus standard care for patients with acute ischemic strok...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.024096

    authors: Shamy MCF,Dewar B,Chevrier S,Wang CQ,Page S,Goyal M,Demchuk AM,Hill MD

    更新日期:2019-04-01 00:00:00

  • Mechanism of in-hospital cerebral ischemia.

    abstract::Of 171 patients evaluated prospectively and consecutively for cerebral ischemia, 26 (15%) developed symptoms while hospitalized. Cerebral ischemia complicated operative procedures in 12 patients, unsuccessful cardioversion in one and coronary angiography in another. Twelve patients had apparent cerebral embolism and 1...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.3.430

    authors: Kelley RE,Kovacs AG

    更新日期:1986-05-01 00:00:00

  • Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury.

    abstract:BACKGROUND AND PURPOSE:Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.004816

    authors: Jackman KA,Zhou P,Faraco G,Peixoto PM,Coleman C,Voss HU,Pickel V,Manfredi G,Iadecola C

    更新日期:2014-05-01 00:00:00

  • Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes.

    abstract:BACKGROUND:A number of clinical syndromes describing the presentation of deep brain infarcts are called lacunar syndromes resulting from small vessel occlusion (SVO). To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI). METHODS AND RESULT...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000158908.48022.d7

    authors: Wessels T,Röttger C,Jauss M,Kaps M,Traupe H,Stolz E

    更新日期:2005-04-01 00:00:00

  • Altered fibrin clot structure/function in patients with cryptogenic ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke. METHODS:Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were determined in 89 patients with patent foramen ovale (PFO) and a history ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.532812

    authors: Undas A,Podolec P,Zawilska K,Pieculewicz M,Jedliński I,Stepień E,Konarska-Kuszewska E,Weglarz P,Duszyńska M,Hanschke E,Przewlocki T,Tracz W

    更新日期:2009-04-01 00:00:00

  • Acute and long-term increase in fracture risk after hospitalization for stroke.

    abstract:BACKGROUND AND PURPOSE:The aims of this study were to determine the magnitude of the increase in fracture risk after hospitalization for stroke, and in particular to determine the time course of this risk. METHODS:The records of the Swedish register of patients admitted during 1987-1996 were examined to identify all p...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.3.702

    authors: Kanis J,Oden A,Johnell O

    更新日期:2001-03-01 00:00:00

  • Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging.

    abstract:BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.12.2321

    authors: Patel MR,Edelman RR,Warach S

    更新日期:1996-12-01 00:00:00

  • Immune reactions associated with cerebral amyloid angiopathy.

    abstract:BACKGROUND AND PURPOSE:Cerebral amyloid angiopathy (CAA) occasionally coexists with cerebral vasculitis. An immune system may influence deposition or degradation of the amyloid in cerebral blood vessels. The purpose of this study was to elucidate immune reactions associated with CAA. METHODS:In 11 elderly patients wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.7.1155

    authors: Yamada M,Itoh Y,Shintaku M,Kawamura J,Jensson O,Thorsteinsson L,Suematsu N,Matsushita M,Otomo E

    更新日期:1996-07-01 00:00:00

  • Experimental pediatric arterial ischemic stroke model reveals sex-specific estrogen signaling.

    abstract:BACKGROUND AND PURPOSE:Pediatric stroke, birth to 18 years, is a significant cause of long-term disability in the United States; however, there is currently little experimental data on the pathophysiology of childhood stroke owing to lack of animal models. We developed a novel mouse model of experimental childhood-onse...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.675124

    authors: Herson PS,Bombardier CG,Parker SM,Shimizu T,Klawitter J,Klawitter J,Quillinan N,Exo JL,Goldenberg NA,Traystman RJ

    更新日期:2013-03-01 00:00:00

  • Glial cells drive preconditioning-induced blood-brain barrier protection.

    abstract:BACKGROUND AND PURPOSE:The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components. METHODS:Seven-minute occlusion of the right middle cerebral ar...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.603266

    authors: Gesuete R,Orsini F,Zanier ER,Albani D,Deli MA,Bazzoni G,De Simoni MG

    更新日期:2011-05-01 00:00:00

  • A novel technique for identification of doppler microembolic signals based on the coincidence method: in vitro and in vivo evaluation.

    abstract:BACKGROUND AND PURPOSE:The applicability of a novel differentiation technique in embolus detection based on the coincidence principle and using a multigate probe was evaluated in this study. METHODS:According to the coincidence method, high-intensity transients should only be classified as microembolic signals if they...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.4.683

    authors: Georgiadis D,Goeke J,Hill M,König M,Nabavi DG,Stögbauer F,Zunker P,Ringelstein EB

    更新日期:1996-04-01 00:00:00

  • Cerebral vasomotor reactivity in normotensive and spontaneously hypertensive rats.

    abstract::Intravenously injected metaraminol induced a larger blood pressure increase in spontaneously hypertensive rats (SHR) than in normotensive controls (NR) when the pressure was raised from the same starting level. Cerebral blood flow (CBF) response in NR was either perfect autoregulation, partial autoregulation or "break...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.10.5.572

    authors: Johansson BB,Nilsson B

    更新日期:1979-09-01 00:00:00

  • Development and validation of a dispatcher identification algorithm for stroke emergencies.

    abstract:BACKGROUND AND PURPOSE:Recent innovations such as CT installation in ambulances may lead to earlier start of stroke-specific treatments. However, such technically complex mobile facilities require effective methods of correctly identifying patients before deployment. We aimed to develop and validate a new dispatcher id...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.634980

    authors: Krebes S,Ebinger M,Baumann AM,Kellner PA,Rozanski M,Doepp F,Sobesky J,Gensecke T,Leidel BA,Malzahn U,Wellwood I,Heuschmann PU,Audebert HJ

    更新日期:2012-03-01 00:00:00

  • Is there a direct link between cerebrovascular activity and cerebrospinal fluid pressure-volume compensation?

    abstract:BACKGROUND AND PURPOSE:Cerebral blood flow is coupled to brain metabolism by means of active modulation of cerebrovascular resistance. This homeostatic vasogenic activity is reflected in slow waves of cerebral blood flow velocities (FV) which can also be detected in intracranial pressure (ICP). However, effects of incr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.485847

    authors: Haubrich C,Czosnyka Z,Lavinio A,Smielewski P,Diehl RR,Pickard JD,Czosnyka M

    更新日期:2007-10-01 00:00:00