Abstract:
:The adsorption behavior of cefonicid on the hanging mercury drop electrode (HMDE) has been examined using cyclic voltammetry and square-wave voltammetry techniques in Britton-Robinson (B-R) buffers in the pH range of 2.0-11.0. The effect of different parameters on the accumulation behavior of the adsorbed species has been evaluated. Sensitive measurements can be achieved after controlled adsorption on the surface of HMDE followed by square-wave voltammetry. Under optimal conditions, a detection limit of 4.0 x 10(-8) M and a linear calibration graph in the range 1.0 x 10(-7)-1.0 x 10(-6) M were obtained. Direct simple determination of cefonicid in urine was established with no manipulation of urine sample other than dilution and subsequent adsorptive stripping voltammetric determination. The detection limit of the method was 1.0 microg x ml(-1) of cefonicid in urine.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Radi A,Wahdan T,El-Ghany NAdoi
10.1016/s0731-7085(02)00701-xsubject
Has Abstractpub_date
2003-04-10 00:00:00pages
1041-6issue
6eissn
0731-7085issn
1873-264Xpii
S073170850200701Xjournal_volume
31pub_type
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