Determination of tungsten in bulk drug substance and intermediates by ICP-AES and ICP-MS.

abstract：:A sensitive enantioselective liquid chromatography-mass spectrometry (LC-MS) assay using a manual solid-phase extraction (SPE) procedure, a non-deuterated internal standard and an ion trap LC-MS was developed to measure (R)- and (S)-albuterol in plasma. Sample extraction from plasma was achieved by a manual SPE extrac...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Jacobson GA,Chong FV,Davies NW

更新日期：2003-04-10 00:00:00

abstract：:The risk assessment of di(2-ethylhexyl) phthalate (DEHP) that migrated from polyvinyl chloride (PVC) medical devices is an important issue for hospitalized patients. Many studies have been conducted to determine the level of DEHP migration. A recent report has indicated that DEHP in blood bags was hydrolyzed by estera...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ito R,Seshimo F,Miura N,Kawaguchi M,Saito K,Nakazawa H

更新日期：2005-10-04 00:00:00

abstract：:The retention of 44 barbituric acid derivatives was determined on porous graphitized carbon (PGC) column using dioxane water mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor and the dioxane concentration in the eluent. Free Wilson analysis combined with stepwise reg...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Forgács E,Cserháti T

更新日期：1998-12-01 00:00:00

abstract：:A methylene blue (MB) poly(vinyl chloride) membrane sensor based on MB-silicotungstate (SLT) ion association as electroactive material was described. The linear response covered the range 1 x 10(-3)-1 x 10(-6) mol x dm(-3) MB solution, with a slope 52.0+/-0.8 mV decade(-1) (pH range 3.0-10.0). The detection limit was ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wen ML,Zhao YB,Chen X,Wang CY

更新日期：1999-01-01 00:00:00

abstract：:Stroke is the third most common cause of death in most industrialized countries. Polygonum multiflorum (He-Shou-Wu, HSW) is one of the traditional Chinese medicines with multiple pharmacological activities which is widely used in Chinese recipe. This study aims to explore the protective effect of HSW on ischemic strok...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li MH,Ruan LY,Chen C,Xing YX,Hong W,Du RH,Wang JS

更新日期：2018-06-05 00:00:00

abstract：:A molecularly imprinted electrochemical sensor for toltrazuril (TZR) detection based on molecularly imprinted polymers (MIPs) immobilized on reduced graphene oxide (rGO) and titanium dioxide (TiO2) modified platinum (Pt) electrode surface was fabricated for the first time. The synergistic fast electron transfer abilit...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Huang X,Wei S,Yao S,Zhang H,He C,Cao J

更新日期：2019-02-05 00:00:00

abstract：:Alkyl quinolone molecules 2-heptyl-4-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) are important quorum sensing signals, which play a mediatory role in the pathogenesis of acute and chronic Pseudomonas aeruginosa infection. A targeted approach inhibiting the bacterial 'multiple virulence factor regulon'...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Turnpenny P,Padfield A,Barton P,Teague J,Rahme LG,Pucci MJ,Zahler R,Rubio A

更新日期：2017-05-30 00:00:00

abstract：:Extracts from the Carica papaya L. plant are widely reported to contain metabolites with antibacterial, antioxidant and anticancer activity. This study aims to analyze the metabolic profiles of papaya leaves and seeds in order to gain insights into their phytomedicinal constituents. We performed metabolite fingerprint...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Gogna N,Hamid N,Dorai K

更新日期：2015-11-10 00:00:00

abstract：:Hydrocortisone degradation products 1, 2, 3, and 4 along with hemiacetal derivatives 5, 6, 7, and 8 were observed through stressed hydrocortisone in solution. Their structures were identified based on HPLC-UV, HPLC-MS, and HPLC-HRMS (high resolution/high accuracy mass spectrometry) analyses as well as reaction mechani...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhang F,Zhou J,Shi Y,Tavlarakis P,Karaisz K

更新日期：2016-09-05 00:00:00

abstract：:Recently it was found that normal adults excrete pipecolic acid primarily as the D-enantiomer even though it is present in the blood stream mainly as the L-enantiomer (i.e. > 98% L). This study of pipecolic acid stereochemistry was extended to subjects with peroxisomal deficiencies since they are known to have high le...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Armstrong DW,Zukowski J,Ercal N,Gasper M

更新日期：1993-10-01 00:00:00

abstract：:Three configurations based on the principles behind flow injection analysis (FIA) are proposed for the automatic determination of enzymatic activity. The proposed approaches are normal, stopped-flow and open-closed FIA. The comparative study of the methods developed from these approaches allows the establishment of th...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Fernandez-Romero JM,Luque de Castro MD,Valcarcel M

更新日期：1989-01-01 00:00:00

abstract：:An HPLC method with fluorescence detection suitable for routine determination of levofloxacin in plasma and dialysate has been validated. Sample preparation was assured by one-step protein precipitation for plasma or direct injection of the dialysate solution, respectively. Separation occurred on an YMC Pro C18 RP col...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Siewert S

更新日期：2006-06-16 00:00:00

abstract：:Hernandezine, a novel anticancer AMPK activator, is a major active constituent of Thalictrum Ranunculaceae. A simple, specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of hernandezine in rat plasma and tissues after intraveno...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Song Y,Wang Z,Zhang B,Zhang Y,Zhang W,Yang C,Meng F,Feng X

更新日期：2017-07-15 00:00:00

abstract：:In early safety assessment studies with the experimental anti-neoplastic drug XP315, a toxic reaction was observed in dogs immediately after intravenous (iv) infusion. The reaction was characterized by severe erythema around the ears, eyes, face and body; ocular hyperemia; head shaking; swelling around the eyes, face,...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sigvardson KW,Adams SP,Barnes TB,Blom KF,Fortunak JM,Haas MJ,Reilly KL,Repta AJ,Nemeth GA

更新日期：2002-01-01 00:00:00

abstract：:Remimazolam is a new chemical entity belonging to the benzodiazepine class of sedative drugs, which shows faster-acting onset and recovery than currently available short-acting sedatives. In the present study, ultra high performance liquid chromatography with synapt high-definition mass spectrometry method combined wi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhou Y,Hu P,Jiang J

更新日期：2017-04-15 00:00:00

abstract：:A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for evaluating the chiral discrimination ability of CYCLOBOND I 2000 DM chiral stationary phase (CSP) towards sertraline and its related enantiomers. The effect of pH, buffer concentration as well as nature of organic mo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rao RN,Talluri MV,Maurya PK

更新日期：2009-10-15 00:00:00

abstract：:S(-)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(-)-satropane, the microdialysis method was employed. The concentration of S(-)-satropane in dialysates was measured by using liqu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Fu J,Feng X,Yuan H,Yan L,Kuang X,Xia Z,Gao X,Yu C,Lu Y,Chen HZ

更新日期：2008-11-04 00:00:00

abstract：:Quantitative whole-body autoradiography (QWBA) and liquid scintillation counting (LSC) have been conducted to determine the metabolic profiles and tissue distribution of [(14)C] labeled artesunate (AS) injection in rats. The QWBA technique showed more accurate results in the quantification of radioactivity in 40 organ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li Q,Xie L,Zhang J,Weina PJ

更新日期：2008-11-04 00:00:00

abstract：:H. sabdariffa has demonstrated positive results against chronic diseases due to the presence of phytochemicals, mainly phenolic compounds. The extraction process of bioactive compounds increases the efficient collection of extracts with high bioactivity. Microwave-Assisted Extraction (MAE) constituted a "green technol...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Pimentel-Moral S,Borrás-Linares I,Lozano-Sánchez J,Arráez-Román D,Martínez-Férez A,Segura-Carretero A

更新日期：2018-07-15 00:00:00

abstract：:In traditional Chinese medicine practice, crude herbs are often subjected to traditional processing (Paozhi in Chinese) for a special medicinal purpose. Bran-frying is one of processing methods for Paeoniae Radix Alba (PRA). Previous studies found that paeoniflorin and paeoniflorin sulfonate, a principle bioactive com...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Xu YY,Long F,Zhang YQ,Xu JD,Kong M,Li SL

更新日期：2018-09-10 00:00:00

abstract：:Extemporaneous oral preparations are routinely compounded in the pharmacy due to a lack of suitable formulations for special populations. Such small-scale pharmacy preparations also present an avenue for individualized pharmacotherapy. Orodispersible films (ODF) have increasingly been evaluated as a suitable dosage fo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Foo WC,Widjaja E,Khong YM,Gokhale R,Chan SY

更新日期：2018-02-20 00:00:00

abstract：:Capillary zone electrophoresis (CZE) with carboxyethyl-beta-cyclodextrin (CE-beta-CD) dissolved in the operating buffer was used for the separation and determination of enantiomers of phenothiazine antihistaminic, dioxopromethazine, in commercial pharmaceutical preparation, eye drops. This chiral selector, negatively ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mikus P,Valásková I,Havránek E

更新日期：2003-09-19 00:00:00

abstract：:A new analytical method for chloramphenicol and its derivatives, chloramphenicol succinate sodium and D-(-)-threo-2-amino-L-[p-nitrophenyl]-1,3-propanediol (chloramphenicol base) in the pure state or in pharmaceutical preparations, is described. The method is based on measuring the blue colour produced by the interact...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Morelli B

更新日期：1987-01-01 00:00:00

abstract：:A rapid, selective and sensitive isocratic reversed-phase HPLC assay coupled with MS/MS detection for simultaneous quantification of fluoxetine and its major active metabolite in serum samples has been developed. Analytes were extracted with a simple three step liquid-liquid procedure and chromatographic separation wa...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Franceschi L,Faggiani A,Furlanut M

更新日期：2009-02-20 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics (PK/PD) of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme (ACE) inhibitor, were investigated. Imidapril was infused subcutaneously for 4 weeks via an osmotic pump implanted under the skin in the back of male spontaneously hypertensive rats ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yamanaka K,Takehara N,Murata K,Banno K,Sato T

更新日期：1997-08-01 00:00:00

abstract：:Indirect biomarkers of recombinant human growth hormone (rhGH), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulin-like growth factor binding proteins (IGFBP-2 and IGFBP-3) and insulin (C-peptide) were measured together with urinary parameters of renal damage (beta(2)-microglobulin a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Pichini S,Ventura R,Palmi I,di Carlo S,Bacosi A,Langohr K,Abellan R,Pascual JA,Pacifici R,Segura J,Zuccaro P

更新日期：2010-12-01 00:00:00

abstract：:A liquid chromatography (LC) method for the determination of ibuprofen in dog plasma is described. Chromatographic separation was performed on a Diamonsil C18 column with a C18 guard column using a binary mixture of acetonitrile and 0.02 mol/l phosphate buffer (pH 6.5) (35:65, v/v) delivered at a flow rate of 1.2 ml/m...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wang P,Qi M,Liu L,Fang L

更新日期：2005-07-15 00:00:00

abstract：:A selective, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample pretreatment invol...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yuan H,Wang F,Tu J,Peng W,Li H

更新日期：2008-03-13 00:00:00

abstract：:A simple, rapid and sensitive isocratic reversed phase HPLC method with UV detection using a monolithic column has been developed and validated for the determination of gliclazide in human plasma. The assay enables the measurement of gliclazide for therapeutic drug monitoring with a minimum quantification limit of 10n...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Foroutan SM,Zarghi A,Shafaati A,Khoddam A

更新日期：2006-10-11 00:00:00

abstract：:Uridine and L-dihydroorotate (DHO) are important intermediates of de novo as well as salvage pathways for the biosynthesis of pyrimidines, which are the building blocks of nucleic acids - DNA and RNA. These metabolites are known to be significant biomarkers of pyrimidine synthesis during the development of DHODH inhib...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yin F,Ling Y,Martin J,Narayanaswamy R,McIntosh L,Li F,Liu G

更新日期：2021-01-05 00:00:00