Abstract：
:S(-)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(-)-satropane, the microdialysis method was employed. The concentration of S(-)-satropane in dialysates was measured by using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Unlike the common solution prepared in normal saline, in which the level of S(-)-satropane in aqueous humor increased rapidly after instillation and reached the maximal level (C(max) of 1.508+/-0.297 microg ml(-1)) within 1h, S(-)-satropane exhibited 3.2-fold greater C(max) and 2.2-fold greater AUC(0-3h) (p<0.05) in the in situ forming gel. The results showed that the in situ forming gel system could improve the ocular bioavailability of S(-)-satropane.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Fu J,Feng X,Yuan H,Yan L,Kuang X,Xia Z,Gao X,Yu C,Lu Y,Chen HZdoi
10.1016/j.jpba.2008.06.001subject
Has Abstractpub_date
2008-11-04 00:00:00pages
840-3issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(08)00341-5journal_volume
48pub_type
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