Abstract：
:A validated, highly sensitive and selective high-pressure liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of quetiapine (QUE) in human Na2EDTA plasma with mass spectrometry (MS) detection. Clozapine (CLO) was employed as an internal standard. Samples were extracted using solid phase extraction (SPE). Oasis HLB cartridges and the concentration of quetiapine was determined by isocratic HPLC-MS/MS. The SRM mode was used for MS/MS detection. The method was validated over a concentration range of 1.0-382.2 ng/mL. Inter- and intra-day precision and accuracy of the proposed method were characterized by relative standard deviation (R.S.D.) and the percentage of deviation, respectively; both were lower than 8%. The developed method was employed in the pharmacokinetic study of quetiapine.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Barrett B,Holcapek M,Huclová J,Borek-Dohalský V,Fejt P,Nemec B,Jelínek Idoi
10.1016/j.jpba.2007.03.034subject
Has Abstractpub_date
2007-06-28 00:00:00pages
498-505issue
2eissn
0731-7085issn
1873-264Xpii
S0731-7085(07)00205-1journal_volume
44pub_type
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