Abstract:
:Retention factors were determined for a set of 26 drugs, for which brain/blood concentration data are available, using immobilised artificial membrane (IAM) chromatography. The compound set represented acidic, basic and neutral drugs from various structural classes. The relationship between IAM retention and lipophilicity (n-octanol-water partition coefficient Koct), molecular size and acid/base character of the drugs and the relationship between brain distribution and IAM retention and the other parameters were analysed. IAM retention was increased with increases in lipophilicity and solute size, and decreased by the ionisation of acidic groups. Ionisation of basic groups had no significant effect. A three-parameter regression model with log Koct, molecular weight and an indicator parameter for the presence of carboxyl group explained 93% of the variation in log kIAM. The concentration ratio between brain and blood (log BB) was only weakly correlated with the IAM chromatographic retention or n-octanol-water partitioning. Three-parameter models taking ionisation and size into account, in addition to either log Koct or log kIAM, explained about 85% of the variation of log BB in the test set. Although IAM chromatography offers no advantage in these models, it seems to provide a better model than n-octanol-water partitioning for the membrane distribution of ionised compounds.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Salminen T,Pulli A,Taskinen Jdoi
10.1016/s0731-7085(96)01883-3subject
Has Abstractpub_date
1997-01-01 00:00:00pages
469-77issue
4eissn
0731-7085issn
1873-264Xpii
S0731708596018833journal_volume
15pub_type
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