Identification of a new impurity in lisinopril.

Abstract:

:LC-UV scan of lisinopril revealed the presence of an unknown impurity (approximately 0.14%) at a relative retention time of 3.26 employing phosphate buffer-acetonitrile as binary gradient system while LC-MS analysis with binary gradient system comprising of a ammonia-ammonium acetate buffer (pH 5.0) and acetonitrile indicated it to be C31H41N3O7. The impurity was isolated by preparative HPLC utilizing a linear gradient of water and acetonitrile. The structural analysis of the isolated product by 1H, 13C NMR, mass spectroscopy and FT-IR revealed it to be a 4-phenyl butanoic acid derivative (CL) of lisinopril.

journal_name

J Pharm Biomed Anal

authors

Shinde V,Trivedi A,Upadhayay PR,Gupta NL,Kanase DG,Chikate R

doi

10.1016/j.jpba.2006.06.046

subject

Has Abstract

pub_date

2007-01-04 00:00:00

pages

381-6

issue

1

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(06)00447-X

journal_volume

43

pub_type

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