Abstract:
:LC-UV scan of lisinopril revealed the presence of an unknown impurity (approximately 0.14%) at a relative retention time of 3.26 employing phosphate buffer-acetonitrile as binary gradient system while LC-MS analysis with binary gradient system comprising of a ammonia-ammonium acetate buffer (pH 5.0) and acetonitrile indicated it to be C31H41N3O7. The impurity was isolated by preparative HPLC utilizing a linear gradient of water and acetonitrile. The structural analysis of the isolated product by 1H, 13C NMR, mass spectroscopy and FT-IR revealed it to be a 4-phenyl butanoic acid derivative (CL) of lisinopril.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Shinde V,Trivedi A,Upadhayay PR,Gupta NL,Kanase DG,Chikate Rdoi
10.1016/j.jpba.2006.06.046subject
Has Abstractpub_date
2007-01-04 00:00:00pages
381-6issue
1eissn
0731-7085issn
1873-264Xpii
S0731-7085(06)00447-Xjournal_volume
43pub_type
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