Differential gurmarin suppression of sweet taste responses in rat solitary nucleus neurons.

Abstract:

:We examined the effect of the sweet transduction blocker gurmarin on taste responses recorded from neurons in the rat solitary nucleus (NST) to determine how gurmarin sensitivity is distributed across neuronal type. Initially, responses evoked by washing the anterior tongue and palate with 0.5 M sucrose, 0.1 M NaCl, 0.01 M HCl, and 0.01 M quinine-HCl were recorded from 35 neurons. For some cells, responses to a sucrose concentration series (0.01-1.0 M) or an array of sweet-tasting compounds were also measured. Gurmarin (10 microg/ml, 2-4 ml) was then applied to the tongue and palate. Stimuli were reapplied after 10-15 min. Neurons were segregated into groups based on similarities among their initial response profiles using hierarchical cluster analysis (HCA). Results indicated that sucrose responses recorded from neurons representative of each HCA-defined class were suppressed by gurmarin. However, a disproportionate percentage of cells in each group displayed sucrose responses that were substantially attenuated after gurmarin treatment. Postgurmarin sucrose responses recorded from neurons that composed 57% of class S, 40% of class N, and 33% of class H were suppressed by >or=50% relative to control. On average, attenuation was statistically significant only in class S and N neurons. Although the magnitude of gurmarin-induced response suppression did not differ across sucrose concentration, responses to different sweet-tasting compounds were differentially affected. Responses to NaCl, HCl, or quinine were not suppressed by gurmarin. Results suggest that information from gurmarin-sensitive and -insensitive receptor processes converges onto single NST neurons.

journal_name

J Neurophysiol

authors

Lemon CH,Imoto T,Smith DV

doi

10.1152/jn.00215.2003

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

911-23

issue

2

eissn

0022-3077

issn

1522-1598

pii

00215.2003

journal_volume

90

pub_type

杂志文章
  • Anatomy and physiology of saccadic long-lead burst neurons recorded in the alert squirrel monkey. II. Pontine neurons.

    abstract::1. The discharge patterns and axonal projections of saccadic long-lead burst neurons (LLBNs) with somata in the pontine reticular formation were studied in alert squirrel monkeys with the use of the method of intraaxonal recording and horseradish peroxidase injection. 2. The largest population of stained neurons were ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.1.353

    authors: Scudder CA,Moschovakis AK,Karabelas AB,Highstein SM

    更新日期:1996-07-01 00:00:00

  • Representation of pleasant and aversive taste in the human brain.

    abstract::In this study, the representation of taste in the orbitofrontal cortex was investigated to determine whether or not a pleasant and an aversive taste have distinct or overlapping representations in this region. The pleasant stimulus used was sweet taste (1 M glucose), and the unpleasant stimulus was salt taste (0.1 M N...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.2001.85.3.1315

    authors: O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F

    更新日期:2001-03-01 00:00:00

  • The quantal component of synaptic transmission from sensory hair cells to the vestibular calyx.

    abstract::Spontaneous and stimulus-evoked excitatory postsynaptic currents (EPSCs) were recorded in calyx nerve terminals from the turtle vestibular lagena to quantify key attributes of quantal transmission at this synapse. On average, EPSC events had a magnitude of ∼ 42 pA, a rise time constant of τ(0) ∼ 229 μs, decayed to bas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00055.2015

    authors: Highstein SM,Mann MA,Holstein GR,Rabbitt RD

    更新日期:2015-06-01 00:00:00

  • Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus.

    abstract::The effect of acute intrahippocampal infusion of brain-derived neurotrophic factor (BDNF) on synaptic transmission in the dentate gyrus was investigated in urethan-anesthetized rats. Medial perforant path-evoked field potentials were recorded in the dentate hilus and BDNF-containing buffer was infused (4 microl, 25 mi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.1.496

    authors: Messaoudi E,Bârdsen K,Srebro B,Bramham CR

    更新日期:1998-01-01 00:00:00

  • Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander.

    abstract::1. Using the patch-clamp technique, we investigated whether the glutamate-elicited current in mechanically isolated cone photoreceptors from the salamander retina is generated by a Cl- channel or a glutamate transporter. 2. The current reversed near the equilibrium potential for Cl-, was decreased by three Cl- channel...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.4.1760

    authors: Picaud SA,Larsson HP,Grant GB,Lecar H,Werblin FS

    更新日期:1995-10-01 00:00:00

  • Movement-related discharge in the cerebellar nuclei persists after local injections of GABA(A) antagonists.

    abstract::Limb movement-related neurons in the cerebellar nuclei (CN) typically produce bursts of discharge in association with movement. Consequently, given the inhibitory nature of the Purkinje cell (PC) projection to CN, it is puzzling that only a minority of movement-related PCs pause; the majority burst. Some of the moveme...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00603.2004

    authors: Holdefer RN,Houk JC,Miller LE

    更新日期:2005-01-01 00:00:00

  • Transfer of motor performance in an obstacle avoidance task to different walking conditions.

    abstract::The aim of this study was to examine whether subjects who have learned a skilled locomotor task can transfer the acquired performance to conditions involving either a change in the external coordinates or in the sensory input from one leg. Subjects were trained to step over an obstacle with minimal foot clearance with...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00397.2004

    authors: Lam T,Dietz V

    更新日期:2004-10-01 00:00:00

  • Differential requirement for NMDAR activity in SAP97β-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses.

    abstract::PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the protot...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00262.2013

    authors: Liu M,Lewis LD,Shi R,Brown EN,Xu W

    更新日期:2014-02-01 00:00:00

  • Covert orienting of attention in macaques. I. Effects of behavioral context.

    abstract::1. A task was used by Posner (1980) to measure shifts of attention that occurred covertly, in the absence of an eye movement or other orienting response. This paradigm was used here to assess the nature of covert attentional orienting in monkeys to develop an animal model for neurophysiological studies. Shifts of atte...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.1.431

    authors: Bowman EM,Brown VJ,Kertzman C,Schwarz U,Robinson DL

    更新日期:1993-07-01 00:00:00

  • Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels.

    abstract::The hypocretin/orexins (Hcrt/Orxs) are hypothalamic neuropeptides that regulate stress, addiction, feeding, and arousal behaviors. They depolarize many types of central neurons and can increase [Ca2+]i in some, including those of the dorsal raphe (DR) and laterodorsal tegmental (LDT) nuclei-two structures likely to co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01388.2007

    authors: Kohlmeier KA,Watanabe S,Tyler CJ,Burlet S,Leonard CS

    更新日期:2008-10-01 00:00:00

  • Object category structure in response patterns of neuronal population in monkey inferior temporal cortex.

    abstract::Our mental representation of object categories is hierarchically organized, and our rapid and seemingly effortless categorization ability is crucial for our daily behavior. Here, we examine responses of a large number (>600) of neurons in monkey inferior temporal (IT) cortex with a large number (>1,000) of natural and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00024.2007

    authors: Kiani R,Esteky H,Mirpour K,Tanaka K

    更新日期:2007-06-01 00:00:00

  • Properties of the sodium current in rat chromaffin cells exposed to nerve growth factor in vitro.

    abstract::1. This paper examines the electrophysiological properties of cultured rat adrenal chromaffin cells at different stages of neuron-like morphological differentiation in response to nerve growth factor (NGF). 2. Chromaffin cells display a large variability in the morphological changes after exposure to NGF. However, a m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.4.1938

    authors: Islas-Suárez L,Gómez-Chavarín M,Drucker-Colín R,Hernández-Cruz A

    更新日期:1994-10-01 00:00:00

  • Distinct contributions of explicit and implicit memory processes to weight prediction when lifting objects and judging their weights: an aging study.

    abstract::Weight predictions used to scale lifting forces adapt quickly when repeatedly lifting unusually weighted objects and are readily updated by explicit information provided about weight. In contrast, weight predictions used when making perceptual judgments about weight are more resistant to change and are largely unaffec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01051.2015

    authors: Trewartha KM,Flanagan JR

    更新日期:2016-09-01 00:00:00

  • On the localization of complex sounds: temporal encoding based on input-slope coincidence detection of envelopes.

    abstract::Behavioral and neural findings demonstrate that animals can locate low-frequency sounds along the azimuth by detecting microsecond interaural time differences (ITDs). Information about ITDs is also available in the amplitude modulations (i.e., envelope) of high-frequency sounds. Since medial superior olivary (MSO) neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00044.2013

    authors: Gai Y,Kotak VC,Sanes DH,Rinzel J

    更新日期:2014-08-15 00:00:00

  • Inaudible high-frequency sounds affect brain activity: hypersonic effect.

    abstract::Although it is generally accepted that humans cannot perceive sounds in the frequency range above 20 kHz, the question of whether the existence of such "inaudible" high-frequency components may affect the acoustic perception of audible sounds remains unanswered. In this study, we used noninvasive physiological measure...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.2000.83.6.3548

    authors: Oohashi T,Nishina E,Honda M,Yonekura Y,Fuwamoto Y,Kawai N,Maekawa T,Nakamura S,Fukuyama H,Shibasaki H

    更新日期:2000-06-01 00:00:00

  • Faster processing of moving compared with flashed bars in awake macaque V1 provides a neural correlate of the flash lag illusion.

    abstract::When the brain has determined the position of a moving object, because of anatomical and processing delays the object will have already moved to a new location. Given the statistical regularities present in natural motion, the brain may have acquired compensatory mechanisms to minimize the mismatch between the perceiv...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00792.2017

    authors: Subramaniyan M,Ecker AS,Patel SS,Cotton RJ,Bethge M,Pitkow X,Berens P,Tolias AS

    更新日期:2018-11-01 00:00:00

  • Dorsal horn cells connected to the lissauer tract and their relation to the dorsal root potential in the rat.

    abstract::We have examined the role of dorsal horn cells that respond to Lissauer tract stimulation in regulating primary afferent depolarization (PAD). PAD was monitored by recording the dorsal root potential (DRP) in the roots of the lumbar cord. Recordings were made of the discharges of Lissauer tract-responsive cells, and t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.2.667

    authors: Lidierth M,Wall PD

    更新日期:1998-08-01 00:00:00

  • Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus.

    abstract::Experiments in both conscious and anesthetized animals indicate that intrathecal (i.t.) strychnine (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral and autonomic responses to cutaneous tactile stimuli. Although STR is known to produce disinhibition of af...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.2.628

    authors: Sherman SE,Luo L,Dostrovsky JO

    更新日期:1997-08-01 00:00:00

  • Full weight-bearing hindlimb standing following stand training in the adult spinal cat.

    abstract::Behavioral and physiological characteristics of standing were studied in nontrained spinal cats and in spinal cats that received daily stand training of the hindlimbs for 12 wk. Training consisted of assisting the cats to stand with full weight support either on both hindlimbs or on one hindlimb (30 min/day, 5 days/wk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.83

    authors: De Leon RD,Hodgson JA,Roy RR,Edgerton VR

    更新日期:1998-07-01 00:00:00

  • Oculomotor task switching: alternating from a nonstandard to a standard response yields the unidirectional prosaccade switch-cost.

    abstract::The completion of an antisaccade (i.e., a nonstandard task) lengthens the reaction time (RT) of a subsequent prosaccade: a behavioral phenomenon termed the unidirectional prosaccade switch-cost. One explanation for the unidirectional prosaccade switch-cost is suppressing a stimulus-driven prosaccade during the precedi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00352.2014

    authors: Weiler J,Heath M

    更新日期:2014-11-01 00:00:00

  • Frequency organization of delay-sensitive neurons in the auditory cortex of the FM bat, Myotis lucifugus.

    abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.366

    authors: Paschal WG,Wong D

    更新日期:1994-07-01 00:00:00

  • Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs.

    abstract::Acetic acid applied to the hind limb of a frog evokes nocifensive behaviors, including a vigorous wiping of the exposed skin, referred to as the wiping response. The aim of this study was to examine the responses of cutaneous primary afferent fibers in frogs to acetic acid (pH 2.84-1.42) applied topically to the skin....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00324.2003

    authors: Hamamoto DT,Simone DA

    更新日期:2003-08-01 00:00:00

  • Probing phase- and frequency-dependent characteristics of cortical interneurons using combined transcranial alternating current stimulation and transcranial magnetic stimulation.

    abstract::Paired-pulse transcranial magnetic stimulation (TMS) and peripheral stimulation combined with TMS can be used to study cortical interneuronal circuitry. By combining these procedures with concurrent transcranial alternating current stimulation (tACS), Guerra and colleagues recently showed that different cortical inter...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00060.2017

    authors: Hussain SJ,Thirugnanasambandam N

    更新日期:2017-06-01 00:00:00

  • Intermuscular coherence reflects functional coordination.

    abstract::Coherence analysis has the ability to identify the presence of common descending drive shared by motor unit pools and reveals its spectral properties. However, the link between spectral properties of shared neural drive and functional interactions among muscles remains unclear. We assessed shared neural drive between ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00204.2017

    authors: Laine CM,Valero-Cuevas FJ

    更新日期:2017-09-01 00:00:00

  • IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation.

    abstract::Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K+ current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K+ ions were investigated in vitro with the whole cell patch-cla...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.4.1749

    authors: Pelz C,Jander J,Rosenboom H,Hammer M,Menzel R

    更新日期:1999-04-01 00:00:00

  • Population response profiles in early visual cortex are biased in favor of more valuable stimuli.

    abstract::Voluntary and stimulus-driven shifts of attention can modulate the representation of behaviorally relevant stimuli in early areas of visual cortex. In turn, attended items are processed faster and more accurately, facilitating the selection of appropriate behavioral responses. Information processing is also strongly i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01090.2009

    authors: Serences JT,Saproo S

    更新日期:2010-07-01 00:00:00

  • Neurotransmitters producing and modulating opaline gland contraction in Aplysia californica.

    abstract::1. Opaline release in Aplysia provides a simple model system for examining the biochemical and electrophysiological mechanisms underlying glandular secretion and its modulation. The opaline gland is a large multivesicular structure, which is innervated by at least three large identified motor neurons located within th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.6.1347

    authors: Tritt SH,Byrne JH

    更新日期:1982-12-01 00:00:00

  • Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1.

    abstract::N-methyl-D-aspartate receptors (NMDARs) are known to regulate axonal refinement and dendritic branching. However, because NMDARs are abundantly present as tri-heteromers (e.g., NR1/NR2A/NR2B) during development, the precise role of the individual subunits NR2A and NR2B in these processes has not been elucidated. Ventr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00823.2009

    authors: Sepulveda FJ,Bustos FJ,Inostroza E,Zúñiga FA,Neve RL,Montecino M,van Zundert B

    更新日期:2010-04-01 00:00:00

  • Incorporating 3D-printing technology in the design of head-caps and electrode drives for recording neurons in multiple brain regions.

    abstract::Recent advances in recording and computing hardware have enabled laboratories to record the electrical activity of multiple brain regions simultaneously. Lagging behind these technical advances, however, are the methods needed to rapidly produce microdrives and head-caps that can flexibly accommodate different recordi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00955.2014

    authors: Headley DB,DeLucca MV,Haufler D,Paré D

    更新日期:2015-04-01 00:00:00

  • Cross-orientation suppression in human visual cortex.

    abstract::Cross-orientation suppression was measured in human primary visual cortex (V1) to test the normalization model. Subjects viewed vertical target gratings (of varying contrasts) with or without a superimposed horizontal mask grating (fixed contrast). We used functional magnetic resonance imaging (fMRI) to measure the ac...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00540.2011

    authors: Brouwer GJ,Heeger DJ

    更新日期:2011-11-01 00:00:00