Object category structure in response patterns of neuronal population in monkey inferior temporal cortex.

Abstract:

:Our mental representation of object categories is hierarchically organized, and our rapid and seemingly effortless categorization ability is crucial for our daily behavior. Here, we examine responses of a large number (>600) of neurons in monkey inferior temporal (IT) cortex with a large number (>1,000) of natural and artificial object images. During the recordings, the monkeys performed a passive fixation task. We found that the categorical structure of objects is represented by the pattern of activity distributed over the cell population. Animate and inanimate objects created distinguishable clusters in the population code. The global category of animate objects was divided into bodies, hands, and faces. Faces were divided into primate and nonprimate faces, and the primate-face group was divided into human and monkey faces. Bodies of human, birds, and four-limb animals clustered together, whereas lower animals such as fish, reptile, and insects made another cluster. Thus the cluster analysis showed that IT population responses reconstruct a large part of our intuitive category structure, including the global division into animate and inanimate objects, and further hierarchical subdivisions of animate objects. The representation of categories was distributed in several respects, e.g., the similarity of response patterns to stimuli within a category was maintained by both the cells that maximally responded to the category and the cells that responded weakly to the category. These results advance our understanding of the nature of the IT neural code, suggesting an inherently categorical representation that comprises a range of categories including the amply investigated face category.

journal_name

J Neurophysiol

authors

Kiani R,Esteky H,Mirpour K,Tanaka K

doi

10.1152/jn.00024.2007

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

4296-309

issue

6

eissn

0022-3077

issn

1522-1598

pii

00024.2007

journal_volume

97

pub_type

杂志文章
  • Question of reference frames: visual direction-selective neurons in the accessory optic system of goldfish.

    abstract::We investigated if visual direction-selective neurons in the pretectal area (APT) of goldfish (Carassius auratus auratus) preferred visual stimuli resulting from rotations around axes corresponding to the best responsive axes of the semicircular canals [optic flow that is consistent to a maximal activation of the hori...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00415.2009

    authors: Masseck OA,Hoffmann KP

    更新日期:2009-11-01 00:00:00

  • Oscillatory and burst discharge across electrosensory topographic maps.

    abstract::1. Three parallel maps of the distribution of tuberous electroreceptor inputs are found in the medullary electrosensory lateral line lobe (ELL) of weakly electric fish. Pyramidal cells in each map are known to respond differentially to the frequency of amplitude modulations (AMs) of external electric fields in vivo. W...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.4.2364

    authors: Turner RW,Plant JR,Maler L

    更新日期:1996-10-01 00:00:00

  • Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.

    abstract::Sensory inputs from muscle, cutaneous, and joint afferents project to the spinal cord, where they are able to affect ongoing locomotor activity. Activation of sensory input can initiate or prolong bouts of locomotor activity depending on the identity of the sensory afferent activated and the timing of the activation w...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00866.2014

    authors: Bui TV,Brownstone RM

    更新日期:2015-04-01 00:00:00

  • LFP power spectra in V1 cortex: the graded effect of stimulus contrast.

    abstract::We recorded local field potentials (LFPs) and single-unit activity simultaneously in the macaque primary visual cortex (V1) and studied their responses to drifting sinusoidal gratings that were chosen to be "optimal" for the single units. Over all stimulus conditions, the LFP spectra have much greater power in the low...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00919.2004

    authors: Henrie JA,Shapley R

    更新日期:2005-07-01 00:00:00

  • Proactive and reactive mechanisms play a role in stepping on inverting surfaces during gait.

    abstract::Ankle inversions have been studied extensively during standing conditions. However, inversion traumas occur during more dynamic conditions, like walking. Therefore in this study sudden ankle inversions were elicited in 12 healthy subjects who stepped on a trap door while walking on a treadmill. First, 10 control trial...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01226.2006

    authors: Nieuwenhuijzen PH,Duysens J

    更新日期:2007-10-01 00:00:00

  • A painful cutaneous laser stimulus evokes responses from single neurons in the human thalamic principal somatic sensory nucleus ventral caudal (Vc).

    abstract::Cutaneous application of painful radiant heat laser pulses evokes potentials (laser-evoked potentials) that can be recorded from scalp or intracranial electrodes. We have now tested the hypothesis that the response of thalamic neurons to a cutaneous laser stimulus occurs at latencies predicted by the conduction delay ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91347.2008

    authors: Kobayashi K,Winberry J,Liu CC,Treede RD,Lenz FA

    更新日期:2009-05-01 00:00:00

  • Dissociation of visual discrimination from saccade programming in macaque frontal eye field.

    abstract::To determine whether visual discrimination in macaque frontal eye field (FEF) is contingent on saccade planning, unit activity was recorded in two monkeys during blocked go and no-go visual search trials. The eye movements made by monkeys after correct no-go trials, in addition to an attenuation of the visual response...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.2.1046

    authors: Thompson KG,Bichot NP,Schall JD

    更新日期:1997-02-01 00:00:00

  • Evidence for synergy between saccades and smooth pursuit during transient target disappearance.

    abstract::Visual tracking of moving objects requires prediction to compensate for visual delays and minimize mismatches between eye and target position and velocity. In everyday life, objects often disappear behind an occluder, and prediction is required to align eye and target at reappearance. Earlier studies investigating eye...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00596.2005

    authors: Orban de Xivry JJ,Bennett SJ,Lefèvre P,Barnes GR

    更新日期:2006-01-01 00:00:00

  • AMPA receptor-mediated miniature synaptic calcium transients in GluR2 null mice.

    abstract::AMPA-type glutamate receptors are normally Ca(2+) impermeable due to the expression of the GluR2 receptor subunit. By using GluR2 null mice we were able to detect miniature synaptic Ca(2+) transients (MSCTs) associated with AMPA-type receptor-mediated miniature synaptic currents at single synapses in primary cortical ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.1.29

    authors: Wang S,Jia Z,Roder J,Murphy TH

    更新日期:2002-07-01 00:00:00

  • Exogenous choline augments transmission at an identified cholinergic synapse in terrestrial mollusk Limax maximus.

    abstract::1. A variety of pharmacological tests indicate that the neuromuscular junction between the salivary burster neuron (SB) and the salivary duct muscle (SD) in the terrestrial mollusk Limax maximus is cholinergic. These include the effects of curare, atropine, and hexamethonium. 2. Exogenously applied choline can act bot...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.2.439

    authors: Barry SR,Gelperin A

    更新日期:1982-08-01 00:00:00

  • Histidine-rich basic peptide: a cardioactive neuropeptide from Aplysia neurons R3-14.

    abstract::We have previously demonstrated that neurons R3-14 of the Aplysia abdominal ganglia specifically express a gene encoding a 108-amino acid neuropeptide precursor. This precursor is postranslationally processed by cleavage of a signal sequence and two internal dibasic residues resulting in three peptides. The peptide pr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.4.1201

    authors: Campanelli JT,Scheller RH

    更新日期:1987-04-01 00:00:00

  • Properties of the GABAA receptor of rat posterior pituitary nerve terminals.

    abstract::1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.3.1135

    authors: Zhang SJ,Jackson MB

    更新日期:1995-03-01 00:00:00

  • Afferent synaptic transmission in a hair cell organ: pharmacological and physiological analysis of the role of the extended refractory period.

    abstract::One feature of neuronal discharge proposed to play a role in coding temporal information is the relative refractory period that follows each action potential. In neurons innervating hair cells, there is an extended refractory period that can last

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01107.2003

    authors: Dawkins R,Sewell WF

    更新日期:2004-08-01 00:00:00

  • A looming-sensitive pathway responds to changes in the trajectory of object motion.

    abstract::Two identified locust neurons, the lobula giant movement detector (LGMD) and its postsynaptic partner, the descending contralateral movement detector (DCMD), constitute one motion-sensitive pathway in the visual system that responds preferentially to objects that approach on a direct collision course and are implicate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00847.2011

    authors: McMillan GA,Gray JR

    更新日期:2012-08-01 00:00:00

  • Processing of visual signals for direct specification of motor targets and for conceptual representation of action targets in the dorsal and ventral premotor cortex.

    abstract::Previous reports have indicated that the premotor cortex (PM) uses visual information for either direct guidance of limb movements or indirect specification of action targets at a conceptual level. We explored how visual inputs signaling these two different categories of information are processed by PM neurons. Monkey...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00452.2009

    authors: Yamagata T,Nakayama Y,Tanji J,Hoshi E

    更新日期:2009-12-01 00:00:00

  • Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation.

    abstract::Transcranial direct current stimulation (tDCS) can produce a lasting polarity-specific modulation of cortical excitability in the brain, and it is increasingly used in experimental and clinical settings. Recent studies suggest that the after-effects of tDCS are related to molecular mechanisms of activity-dependent syn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00319.2011

    authors: Ranieri F,Podda MV,Riccardi E,Frisullo G,Dileone M,Profice P,Pilato F,Di Lazzaro V,Grassi C

    更新日期:2012-04-01 00:00:00

  • Effects of tetanic contraction of motor units of similar type on the initial stiffness to ramp stretch of the cat peroneus longus muscle.

    abstract::1. The stiffness during the initial portion of a ramp stretch was measured in cat peroneus longus muscle at rest and during maximal tetanic contractions produced by increasing numbers of motor units of the same type [slow (S), fast fatigue resistant (FR), or fast fatigable (FF)]. 2. This initial ramp stiffness was def...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.6.1724

    authors: Petit J,Filippi GM,Gioux M,Hunt CC,Laporte Y

    更新日期:1990-12-01 00:00:00

  • Region-specific regulation of voltage-gated intrinsic currents in the developing optic tectum of the Xenopus tadpole.

    abstract::Across the rostrocaudal (RC) axis of the Xenopus tadpole optic tectum exists a developmental gradient. This gradient has served as a useful model to study many aspects of synapse and dendrite maturation. To compliment these studies, we characterized how the intrinsic excitability, the ease in which a neuron can fire a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00068.2014

    authors: Hamodi AS,Pratt KG

    更新日期:2014-10-01 00:00:00

  • Presynaptic and extrasynaptic regulation of posterior nucleus of thalamus.

    abstract::The posterior nucleus of thalamus (PO) is a higher-order nucleus involved in sensorimotor processing, including nociception. An important characteristic of PO is its wide range of activity profiles that vary across states of arousal, thought to underlie differences in somatosensory perception subject to attention and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00862.2016

    authors: Park A,Li Y,Masri R,Keller A

    更新日期:2017-07-01 00:00:00

  • Ionic mechanisms underlying tonic and burst firing behavior in subfornical organ neurons: a combined experimental and modeling study.

    abstract::Subfornical organ (SFO) neurons exhibit heterogeneity in current expression and spiking behavior, where the two major spiking phenotypes appear as tonic and burst firing. Insight into the mechanisms behind this heterogeneity is critical for understanding how the SFO, a sensory circumventricular organ, integrates and s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00340.2018

    authors: Medlock L,Shute L,Fry M,Standage D,Ferguson AV

    更新日期:2018-11-01 00:00:00

  • Linking express saccade occurance to stimulus properties and sensorimotor integration in the superior colliculus.

    abstract::Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00047.2015

    authors: Marino RA,Levy R,Munoz DP

    更新日期:2015-08-01 00:00:00

  • Contribution of execution noise to arm movement variability in three-dimensional space.

    abstract::Reaching movements are subject to noise associated with planning and execution, but precisely how these noise sources interact to determine patterns of endpoint variability in three-dimensional space is not well understood. For frontal plane movements, variability is largest along the depth axis (the axis along which ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00495.2011

    authors: Apker GA,Buneo CA

    更新日期:2012-01-01 00:00:00

  • Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension.

    abstract::Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms vary greatly from trial to trial due to activity unrelated to the stimulus, it has been demonstrated that spoken sentences can be discriminated based on theta-band (3-7 Hz) pha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00251.2010

    authors: Howard MF,Poeppel D

    更新日期:2010-11-01 00:00:00

  • Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.

    abstract::Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superf...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00703.2016

    authors: Akiyama T,Nagamine M,Davoodi A,Ivanov M,Carstens MI,Carstens E

    更新日期:2017-01-01 00:00:00

  • Temporal cueing enhances neuronal and behavioral discrimination performance in rat whisker system.

    abstract::Since sensory systems operate with a finite quantity of processing resources, an animal would benefit from prioritizing processing of sensory stimuli within a time window that is expected to provide key information. This behavioral manifestation of such prioritization is known as attention. Here, we investigate attent...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00604.2018

    authors: Lee CCY,Clifford CWG,Arabzadeh E

    更新日期:2019-03-01 00:00:00

  • Spatial bias in estimating the position of visual and proprioceptive targets.

    abstract::When people match an unseen hand to a visual or proprioceptive target, they make both variable and systematic (bias) errors. Variance is a well-established factor in behavior, but the origin and implications of bias, and its connection to variance, are poorly understood. Eighty healthy adults matched their unseen righ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00633.2017

    authors: Liu Y,Sexton BM,Block HJ

    更新日期:2018-05-01 00:00:00

  • Dimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect K(ATP) channels.

    abstract::The plant-derived insecticides have introduced a new concept in insecticide research. In response to insect attacks, some plants can release volatile sulfur compounds such as dimethyl disulfide (DMDS) in the atmosphere, which are lethal for the generalist insects. We demonstrate that DMDS induced an uncommon complex n...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01096.2002

    authors: Dugravot S,Grolleau F,Macherel D,Rochetaing A,Hue B,Stankiewicz M,Huignard J,Lapied B

    更新日期:2003-07-01 00:00:00

  • Live imaging of bulk endocytosis in frog motor nerve terminals using FM dyes.

    abstract::We observed endocytosis in real time in stimulated frog motor nerve terminals by imaging the growth of large membrane infoldings labeled with a low concentration of FM dye. The spatial and temporal information made available by these experiments allowed us to image several new aspects of this synaptic vesicle recyclin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00123.2011

    authors: Gaffield MA,Romberg CF,Betz WJ

    更新日期:2011-08-01 00:00:00

  • L-type calcium channels: the low down.

    abstract::L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihyd...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00486.2004

    authors: Lipscombe D,Helton TD,Xu W

    更新日期:2004-11-01 00:00:00

  • Temperature neurons in the crotaline trigeminal ganglia.

    abstract::1. Intrasomal recordings were made with microelectrodes from 153 warm (infrared) neurons in the trigeminal ganglia of 36 crotaline snakes, Trimeresurus flavoviridis. Background discharges were observed at room temperature. The 153 warm neurons were classified into two groups: 81 were sensitive to less than or equal to...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.623

    authors: Terashima S,Liang YF

    更新日期:1991-08-01 00:00:00