Abstract：
:The abdominal distribution of orally ingested radioopaque markers is used to assess total and segmental colonic transit in constipated patients, but interpretation may depend on whether studies are carried out on a full colon or one cleared of faeces. We asked 25 severely constipated patients (age 18-74; 22 F, 3 M) to ingest 50 polyethylene markers (4 mm x 2 mm) at breakfast on 2 occasions 1 month apart. No bowel preparation was used for study 1 but for the second study 2 doses of Sodium Picosulphate (2 x 10 mg) were taken 3 days before ingestion of the markers. All subjects reported a good result which had ceased a day before taking the markers. Marker distribution was assessed by a plain abdominal film taken 72 hours after ingestion. All 25 subjects had more than 50% of markers present at 72 h in study one. Of these 4 showed evidence of outlet obstruction with more than 50% of ingested markers in the rectum. In the remaining 21 subjects markers were distributed throughout the colon in a pattern indicating colonic inertia. Following the administration of purgative there was no significant change in the mean number of markers retained but patterns of marker distribution for individual subjects did alter. Of the 21 patients who previously had colonic inertia, 3 showed outlet obstruction and 1 showed no evidence of delayed transit. Of the 4 patients with a pattern of outlet obstruction in the first study, 2 showed no evidence of delayed transit after Picolax.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Bergin AJ,Read NWdoi
10.1007/BF00299331subject
Has Abstractpub_date
1993-07-01 00:00:00pages
75-7issue
2eissn
0179-1958issn
1432-1262journal_volume
8pub_type
杂志文章abstract：:Twenty-two patients treated for rectal trauma between 1975 and 1985 were reviewed. There were 13 males and nine females, of mean age 38 years (18-72 years). Causes included gunshot (2), sexual trauma (8), road accident (5), impalement (5), polypectomy (2). Two patients died, giving a treatment mortality of 9%. Cases w...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01648441
更新日期：1986-07-01 00:00:00
abstract：PURPOSE:Aberrant activation of the Wnt/β-catenin pathway plays a major role in the development of colorectal carcinoma (CRC). Axin 2 is a key protein of this pathway and is upregulated in CRC. Here, we investigated RNA- and protein expression of axin 2 in CRC tissues at the single cell level. Moreover, the association ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1709-6
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Ulcerative colitis is an established risk factor for colorectal cancer but dysplasia reports are much more frequent than invasive neoplasm diagnosis. The effective activation of T lymphocytes that provide antitumor surveillance requires the presence of costimulation molecules such as CD80 and CD86 o...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0095-8
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Some patients with uncomplicated diverticulitis have extraluminal air. Our objective was to determine if patients with Hinchey 1a diverticulitis and isolated extraluminal air present more severe episode than patients without extraluminal air. METHODS:The present study is a monocentric observational retrospe...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03424-w
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Ileal-pouch anal anastomosis has an established role in the treatment of ulcerative colitis. Controversy exists regarding the routine use of a diverting ileostomy. The aim of this study was to review the clinical and functional outcome of patients undergoing restorative proctocolectomy in the absence of a di...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0243-1
更新日期：2007-10-01 00:00:00
abstract：AIM:Inflammatory bowel diseases (IBD) are associated with an increased risk for colorectal cancer (CRC). However and despite significant advances in the management of IBD and CRC, the prognosis of IBD-related CRC (IBD-CRC) remains controversial. The aim of the present case-control study was to compare the prognosis of ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3049-z
更新日期：2018-07-01 00:00:00
abstract：:440 patients were prospectively enrolled in a randomized, multicenter trial to compare 4 types of manual (84 interrupted end-to-end, 77 continuous end-to-end, 82 interrupted end-to-side, and 91 continuous end-to-side) (polyglycolic derived suture) and 1 type of stapled (106 side-to-side with GIA+TA devices) ileocoloni...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00341273
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:To identify factors associated with timing of stoma reversal after rectal cancer surgery in a large Swedish register-based cohort. METHODS:Three thousand five hundred sixty-four patients with rectal cancer who received a protective stoma during surgery in 2007-2013 were identified in the Swedish colorectal can...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-2994-x
更新日期：2018-05-01 00:00:00
abstract：:Although the cause of Crohn's disease remains obscure, considerable progress has been made in recent years in unraveling the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases. Th-1 lymphocytes seem to orchestrate the inflammation through the production of proinflammatory...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s003840050182
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:Lynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures. METHODS:We evaluated 147 asympt...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3002-1
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Colonic manometry (CM) can be of additive value in the diagnostic workup of colonic motility in chronic constipated patients. However, it is claimed that colonic motor disturbances occur in normal-transit constipation (NTC) and slow-transit (STC) constipation, as measured using a radio-opaque marker study, and ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03376-1
更新日期：2019-10-01 00:00:00
abstract：:Twenty-one patients suffering from rectal prolapse (n = 15) or internal rectal procidentia (n = 6) were investigated clinically and by anorectal manometry prior to and six months following retopexy. Rectal prolapse was associated with incontinence in 67% (10/15) of the patients preoperatively. The moderately or severe...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01649678
更新日期：1988-03-01 00:00:00
abstract：PURPOSE:Several studies demonstrate an increased prevalence and concordance of inflammatory bowel disease among the relatives of patients. Other studies suggest that genetic influence is over-estimated. The aims of this study are to evaluate the phenotypic expression and the treatment requirements in familial inflammat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-017-2791-y
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis. The molecular mechanisms underlying their activation in response to profibrogenic mediators, however, are largely unknown. Extending previous studies on the transcriptional regulation of PSC activation, we ha...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-003-0565-1
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Surgical site infection (SSI) continues to be a challenge in colorectal surgery. Over the years, various modalities have been used in an attempt to reduce SSI risk in elective colorectal surgery, which include mechanical bowel preparation before surgery, oral antibiotics and intravenous antibiotic prophylaxi...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-016-2662-y
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Despite the excellent results published on circular stapled mucosectomy (CSM), there is still some concern about the application of PPH-33 in the advanced haemorrhoidal disease, where a major prolapse may lead to insufficient resection and ensuing early recurrence. This study is aimed at comparing t...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-004-0720-3
更新日期：2006-01-01 00:00:00
abstract：:The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still are unknown, but the induction of apoptosis is one of the possible mechanisms. We attempted to demonstrate the role of mitogen-activated protein (MAP) kinases, generally considered to be important mediators of proliferat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840100301
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The surgical management of advanced primary or recurrent rectal cancer may involve the lower ureter or ureterovesical junction. With unilateral involvement, reconstruction of the ureters with salvage of the ipsilateral renal function should be considered. PATIENTS AND METHODS:With optimal exposure ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-002-0399-2
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:This study evaluates the erectile function of male patients treated by preoperative radiotherapy followed by surgery and surgery alone for locally advanced rectal cancer. METHODS:A total of 112 men treated by total mesorectal excision with autonomic nerve preservation were included. Seventy-three patients were...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-010-0879-8
更新日期：2010-05-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the effect of a structured hands-on workshop on the detection rate of obstetric anal sphincter injuries. METHODS:All physicians attending the delivery ward in our institution participated in a structured obstetric anal sphincter injury hands-on workshop developed by Dr. ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2365-9
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The traditional therapy for perforated sigmoid diverticulitis with peritonitis is emergency colectomy usually with colostomy. We report laparoscopic exploration with peritoneal lavage as an alternative in seven patients who required emergency surgery for diverticulitis. METHODS:Six patients presented with d...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-009-0641-2
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PS...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究
doi：10.1007/s00384-018-3123-6
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Colon capsule endoscopy (CCE) is a reliable method to detect colonic polyps in the well-prepared colon. As CCE evaluation can be time consuming, a new software algorithm might aid in reducing evaluation time. OBJECTIVES:The aim of the study was to evaluate whether it is feasible to reliably detect colon pol...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03393-0
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:Although the regional lymph node status is essential for staging of colorectal cancer, the importance of the total number of collected nodes remains controversial. Our aim was to examine the impact of the metastatic lymph node ratio (LNR) on the survival of patients with Dukes C colorectal cancer. METHODS:All ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1340-3
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1782-x
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Compared with the open approach, laparoscopic total mesorectal excision (TME) achieves faster patient recovery, reduces morbidity rates, and shortens hospital stay. However, in laparoscopic low anterior resection (L-LAR), conversion to open surgery is required in almost 20% of cases. Transanal TME (Ta-TME) comb...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00384-018-2996-8
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:The purpose of this study is to see if the distance to a hospital performing colon cancer surgery is a risk factor for emergency surgical intervention and to determine the variability between defined but demographically divergent catchment areas. METHODS:Data on patients living in Västerbotten County who under...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3074-y
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:It is controversial whether patients fare better with conservative or surgical treatment in certain stages of acute diverticulitis (AD), in particular when phlegmonous inflammation or covered micro- or macro-perforation are present. The aim of this study was to determine long-term quality of life (QoL) for AD p...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-2969-y
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND AND AIMS:A 5-bp insertion-deletion (indel) polymorphism in the promoter of interferon regulatory factor 5 (IRF5) has been associated with inflammatory bowel diseases (IBD). This polymorphism generates an additional binding site for the transcription factor SP1 and has been shown to augment the expression of ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-010-0874-0
更新日期：2010-05-01 00:00:00
abstract：PURPOSE:Sound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion. METHODS:Forty colorectal neoplasms, contributed by 40 pat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03790-w
更新日期：2020-10-28 00:00:00
