Abstract:
:Although the cause of Crohn's disease remains obscure, considerable progress has been made in recent years in unraveling the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases. Th-1 lymphocytes seem to orchestrate the inflammation through the production of proinflammatory cytokines such as interferon-gamma, interleukin-1 beta, and tumor necrosis factor (TNF) alpha. Since the isolation and characterization of TNF and its two receptors detailed regulatory processes for transcription, secretion, and postreceptor actions of TNF are now rapidly being discovered. Genetically engineered monoclonal antibodies specifically directed against TNF-alpha are only the first drugs acting against TNF, available for clinical use now in the treatment of Crohn's disease. A single intravenous injection of these mono-antibodies produce very dramatic clinical, endoscopic, and histological responses in most refractory patients. More data on long-term safety, efficacy (mainly after repeated infusions) and the exact role in combination with standard therapies are awaited. Until then these drugs should be reserved for patients not responding to standard immunomodulatory therapy and not amenable to surgery. The exciting "TNF story" very nicely illustrates how the benchmark of basic immunological research now provides us with very potent and rationally designed drugs. Careful monitoring of safety of repeated and long-term use of these agents, interfering with very basic physiological events, is mandatory.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Baert FJ,Rutgeerts PRdoi
10.1007/s003840050182subject
Has Abstractpub_date
1999-02-01 00:00:00pages
47-51issue
1eissn
0179-1958issn
1432-1262journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:In acute or chronic inflammatory bowel disease (IBD) interferon gamma (IFNgamma) is still considered to be an important pro-inflammatory mediator. In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IE...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-003-0570-4
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:Postoperative ileus (POI) is one of the complications that can occur after every surgical procedure including arthroplasty. It can have detrimental consequences for the patient and portrays an economic burden on health care systems. The risk factors for POI after arthroplasty described in the literature are sca...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-018-3184-6
更新日期:2019-02-01 00:00:00
abstract::440 patients were prospectively enrolled in a randomized, multicenter trial to compare 4 types of manual (84 interrupted end-to-end, 77 continuous end-to-end, 82 interrupted end-to-side, and 91 continuous end-to-side) (polyglycolic derived suture) and 1 type of stapled (106 side-to-side with GIA+TA devices) ileocoloni...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF00341273
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-005-0029-x
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To identify factors associated with timing of stoma reversal after rectal cancer surgery in a large Swedish register-based cohort. METHODS:Three thousand five hundred sixty-four patients with rectal cancer who received a protective stoma during surgery in 2007-2013 were identified in the Swedish colorectal can...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-018-2994-x
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND AIMS:This pilot study examines whether single-dose intravenous metronidazole preoperatively is at least as effective as a broad-spectrum multi-drug regimen in preventing infection-related wound complications following excision of pilonidal sinuses with primary closure. PATIENTS AND METHODS:A double-blin...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00384-002-0416-5
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who nor...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s00384-010-1058-7
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Evacuation disorders associated with a rectocele can be improved by rectocele repair. This study investigated whether anorectal function tests results change after rectocele repair. PATIENTS AND METHODS:Fourteen patients with 2nd or 3rd degree rectocele and evacuation disorder were treated by poste...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s00384-002-0469-5
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:Anastomotic leakage after low anterior resection for rectal cancer is a critical problem. Many risk factors have been suggested and surgical techniques have improved, but anastomotic leakage remains a major postoperative challenge. This study sought to create a nomogram for precise prediction of anastomotic lea...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-018-2970-5
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:A cohort study was carried out to analyse quality indicators in the diagnosis and treatment of rectal carcinoma. METHODS:A total of 2,470 patients with rectal carcinoma treated between 1985 and 2007 at the Department of Surgery, University of Erlangen, were analysed and compared within four time intervals. RE...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-009-0736-9
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND STUDY AIMS:Computer-generated enhancements, which can highlight the surface and color of a colonic lesion, may be helpful to predict the histology; however, it remains unclear whether this technology can distinguish neoplastic from non-neoplastic colon polyps when the polyps are <1 cm without magnificati...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-011-1319-0
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is increasingly encountered in children. Early disease is associated with higher complication rate with increased incidence of surgical intervention. PATIENTS AND METHODS:From January 2010 to June 2015, 25 patients in the pediatric and adolescent age groups with IBD underwen...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-015-2388-2
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:The favorable oncological impact of D3 lymph node dissection after colon cancer surgery has been described previously. However, D3 lymph node dissection is potentially more invasive than conventional D2 lymph node dissection. The oncological merit of D3 lymph node dissection in elderly patients with colon cance...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-018-03233-7
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Resource limitations are a concern in most modern public hospital systems. The aim of this study is to prospectively quantify the total caseload of a tertiary colorectal surgery unit to identify areas of redundancy. METHODS:Data was collected prospectively at all points of clinical care (outpatient clinic, inp...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-016-2556-z
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Standard therapy for locally advanced rectal cancer (LARC) is concurrent neo-adjuvant chemo-radiation using infusional 5-fluorouracil (CIV-5-FU). Capecitabine (CAP) offers a convenient oral replacement for CIV-5-FU. There is no randomized trial comparing infusional 5-FU to capecitabine. We retrospectively co...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-007-0382-z
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:This study investigates whether contrast enema (CE) and flexible endoscopy (FE) should be performed routinely after low anterior resection (LAR) before ileostomy reversal. Additionally, the impact of previous anastomotic leakage (AL) on diagnostic test accuracy (DTA) was assessed. METHODS:This is a retrospecti...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-020-03766-w
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:Our study is the first meta-analysis to compare total mesorectal excision (TME) plus lateral lymph node dissection (LLND) with TME on rectal cancer patients regarding outcomes including overall survival, disease-free survival, local recurrence, complications, urinary dysfunction, and sexual dysfunction. METH...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-020-03610-1
更新日期:2020-06-01 00:00:00
abstract::Since 1983 we have used radial and linear ultrasound probes in the laboratory and clinical examination of the rectum. Normal endosonographic appearances have been characterised by examining polyethylene membranes and resection specimens. Twenty normal subjects and 11 patients with rectal cancer have been examined, and...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF01648338
更新日期:1986-10-01 00:00:00
abstract:INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pa...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-018-3218-0
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:Circulating tumor cells (CTCs) represent an independent prognostic factor in metastatic colorectal cancer, while their significance in early stages is still an open issue. The aim of the study is to investigate the role of CTCs in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (CT-RT). METHODS...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-014-1958-z
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:It is generally believed that resumption of feeding after colorectal resection is indicated only after recovery of bowel function. This study was designed to verify safety, feasibility, and tolerance of early oral postoperative feeding (EOF) outside an enhanced recovery after surgery (ERAS) program. MATER...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s00384-011-1138-3
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Malignant cells often exhibit perturbations in the pattern of cytosine methylation. Hypermethylation of CpG islands has been extensively documented, but genome-wide hypomethylation is also a common feature of malignant cells. The bulk of cytosine methylation in the mammalian genome occurs on repetit...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-003-0539-3
更新日期:2004-03-01 00:00:00
abstract:AIMS:Percutaneous tibial nerve stimulation (PTNS) and sacral nerve stimulation (SNS) are both second-line treatments for faecal incontinence (FI). To compare the clinical outcomes and effectiveness of SNS versus PTNS for treating FI in adults. METHOD:A literature search of MEDLINE, Embase, Science Citation Index Expan...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00384-018-2976-z
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to assess the value of metastatic lymph node ratio (LNR) in predicting disease-free survival (DFS) in patients with stage III adenocarcinoma of the colon. MATERIALS AND METHODS:From 1995 to 2003 inclusively, a total of 624 patients featuring stage III adenocarcinoma of the colo...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-009-0738-7
更新日期:2009-11-01 00:00:00
abstract::Colonoscopy is the established method of surveillance of subjects at high risk of developing colorectal neoplasia. Its role in the surveillance of a population at moderate risk is less clear, however, as the procedure is expensive, time consuming and occasionally hazardous. The aim of this study was to estimate by cas...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s003840100316
更新日期:2001-09-01 00:00:00
abstract::A retrospective study of 87 patients, subjected to colostomy closure between 1976 and 1987, was conducted in order to evaluate the role of 8 potential risk factors on morbidity and mortality. Possible risk factors were age greater than 65 years, presence of hypoalbuminaemia (less than 3.0 gr%), anaemia (Hb less than 1...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00298472
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND AND AIMS:We evaluated the incidence of dysplasia in the mucosectomy area using resected specimens to determine preoperative risk factors for the occurrence of dysplasia in this area. PATIENTS AND METHODS:We prospectively studied a consecutive series of 137 patients, each of whom underwent a restorative proc...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-006-0178-6
更新日期:2007-04-01 00:00:00
abstract::Leukocyte emigration from blood to sites of inflammation involves sequential interaction of specific adhesion molecules expressed by both leukocytes and endothelial cells. The central steps in leukocyte-endothelial adhesive interactions are leukocyte rolling, sticking, and transmigration. This study investigated the e...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s003840050214
更新日期:1999-11-01 00:00:00
abstract::Cryosurgery is one of the palliative treatment options to decrease local symptoms due to rectal carcinoma. A total of 106 patients (aged 45-92 years) underwent palliative cryosurgery for primary rectal cancer. Inclusion criteria were prohibitive surgical risk, unresectability, distant metastases, patient refusal of su...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s003840050206
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND AIMS:The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon. METHODS:Fisher rats received intracolonic administration (0.5 ml) of saline or acetic acid at lo...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s003840100332
更新日期:2001-11-01 00:00:00