Abstract:
PURPOSE:To identify factors associated with timing of stoma reversal after rectal cancer surgery in a large Swedish register-based cohort. METHODS:Three thousand five hundred sixty-four patients with rectal cancer who received a protective stoma during surgery in 2007-2013 were identified in the Swedish colorectal cancer register. Time to stoma reversal was evaluated over a follow-up period of one and a half years. Factors associated with timing of stoma reversal were analysed using Cox regression analysis. Reversal within 9 months (12 months if adjuvant chemotherapy) was considered latest expected time to closure. RESULTS:Stoma reversal was performed in 2954 (82.9%) patients during follow-up. Patients with post-secondary education had an increased chance for early stoma reversal (HR 1.13; 95% CI 1.02-1.25). Postoperative complications (0.67; 0.62-0.73), adjuvant chemotherapy (0.63; 0.57-0.69), more advanced cancer stage (stage III 0.74; 0.66-0.83 and stage IV 0.38; 0.32-0.46) and higher ASA score (0.80; 0.71-0.90 for ASA 3-4) were associated with longer time to reversal. Two thousand four hundred thirty-seven (68.4%) patients had stoma reversal within latest expected time to closure. Factors associated to decreased chance of timely reversal were more advanced cancer stage (stage III 0.64; 0.50-0.81 and stage IV 0.19; 0.13-0.27), postoperative complications (0.50; 0.42-0.59) and higher ASA score (0.77; 0.61-0.96 for ASA 3-4). CONCLUSIONS:Patients with a high level of education had a higher chance of timely reversal but medical factors had a stronger association to time to reversal. Patients with advanced rectal cancer are at high risk for non-reversal and should be considered for permanent stoma.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Gustafsson CP,Gunnarsson U,Dahlstrand U,Lindforss Udoi
10.1007/s00384-018-2994-xsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
593-600issue
5eissn
0179-1958issn
1432-1262pii
10.1007/s00384-018-2994-xjournal_volume
33pub_type
杂志文章abstract:PURPOSE:Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224-2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit a...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s00384-010-0882-0
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:Cervical vagus nerve stimulation (VNS) prevents manipulation-induced intestinal inflammation and improves intestinal transit in a mouse model of postoperative ileus (POI). Cervical VNS, however, is accompanied by cardiovascular and respiratory side effects. In view of potential clinical application, we therefor...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-015-2435-z
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-04-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2018-03-01 00:00:00
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journal_title:International journal of colorectal disease
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doi:10.1007/s00384-016-2576-8
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:The transplantation of neural crest derived stem cells (NCSC) is a potent alternative for the treatment of Hirschsprung's disease (HSCR). Cells to be transplanted should find an appropriate microenvironment to survive and differentiate. Influences of HSCR-smooth-muscle-protein extracts upon isolated myente...
journal_title:International journal of colorectal disease
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更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Extrarenal retroperitoneal angiomyolipomas are benign tumours of mesenchymal tissue origin. The diagnosis of these tumours is usually based on the perioperative findings and confirmed by the resultant specimen's histology. The main differential diagnosis is liposarcoma, and accurate preoperative imaging comb...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-003-0492-1
更新日期:2003-11-01 00:00:00
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更新日期:2016-10-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Photodynamic therapy (PDT) is a new treatment modality for early esophageal neoplasia. With two absorption maxima in the visible light range (550 and 588 nm) hypericin is a very promising photosensitizer for PDT with incoherent light sources. We studied the effects of photosensitizing hypericin in b...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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更新日期:2018-06-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-008-0499-8
更新日期:2008-11-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00341187
更新日期:1993-09-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
abstract::In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and devel...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS:A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:1986-07-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-28 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-015-2354-z
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,多中心研究
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更新日期:2016-09-01 00:00:00