Abstract:
:The concentrations of serum calcium, parathyroid hormone (PTH), 25 Hydroxyvitamin D (25OHD), and 1,25 Dihydroxyvitamin D (1,25(OH)2D) were determined in 99 Saudi patients with sickle cell disease and in 104 matching healthy controls. Serum calcium and 25OHD were significantly lower in the patients, with 14% and 12% of them had serum calcium and 25OHD concentrations, respectively, below the normal range. PTH was significantly higher in the patients, with 31% having values above the normal range. There was no significant difference between patients and controls in regard to 1,25(OH)2D. There was a significant inverse correlation of 25OHD with PTH and a direct correlation of PTH with 1,25(OH)2D. Dietary intake of calcium and vitamin D was adequate in both patients and controls. The results indicate that sickle cell patients have hypocalcaemic tendency associated with supranormal PTH, and imply impaired intestinal absorption of calcium and vitamin D leading to a disturbed calcium metabolism which might contribute to the skeletal changes seen in sickle cell disease.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Mohammed S,Addae S,Suleiman S,Adzaku F,Annobil S,Kaddoumi O,Richards Jdoi
10.1177/000456329303000108subject
Has Abstractpub_date
1993-01-01 00:00:00pages
45-51eissn
0004-5632issn
1758-1001journal_volume
30 ( Pt 1)pub_type
杂志文章abstract::A recently introduced turbidimetric immunoassay using shell/core particles for determination of myoglobin (Turbiquant Myoglobin, Behringwerke, Marburg, Germany) was evaluated on the Behring Turbitimer analyzer. Intra-assay CV varied between 1.0% and 3.2%; interassay CV was between 2.0% and 3.6%. Linear results were ob...
journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456329102800509
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:To date, the difference in microRNA expression profiles in tears of dry eye patients and healthy people has not been reported. In current study, we evaluated the significance of microRNAs and transforming growth factor beta2 (TGF-β2) in distinguishing dry eye. METHODS:A total of 138 patients with dry eye fr...
journal_title:Annals of clinical biochemistry
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doi:10.1177/0004563220961746
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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更新日期:1988-11-01 00:00:00
abstract::Immunoreactive melatonin has been studied in normal human volunteers, both men and women, at different times of day and different times of the year. At 2400, but not at 0800 or 1200, there are very large inter-individual variations in mean levels, the maximum difference being fivefold. Intra-individual variations are ...
journal_title:Annals of clinical biochemistry
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更新日期:1979-11-01 00:00:00
abstract::The spectral interference caused by haemoglobin in the calcium-cresolphthalein complexone reaction was investigated. The results show that the nature of the haemoglobin derivative in the reaction mixture influences the degree of interference; in turn, the derivative formed depends on the order in which the sample and ...
journal_title:Annals of clinical biochemistry
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doi:10.1177/000456329002700212
更新日期:1990-03-01 00:00:00
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章,评审
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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更新日期:1980-01-01 00:00:00
abstract::This review describes the development and application of a novel test to determine levels of human immunoreactive trypsin, an enzyme produced solely by the pancreas, in biological fluids. Being organ-specific, the assay of immunoreactive trypsin should be an ideal marker of pancreatic function, and this is supported b...
journal_title:Annals of clinical biochemistry
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doi:10.1177/000456327901600131
更新日期:1979-05-01 00:00:00
abstract::The total cost of a haematology and clinical chemistry laboratory, including external and hospital costs, was studied in a district general hospital in The Netherlands. The main conclusion is that the number of samples analysed is the most important cost-setting factor, but that reduction in the number of requests doe...
journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456328402100206
更新日期:1984-03-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:1998-05-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:1992-07-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:2017-11-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456328101800507
更新日期:1981-09-01 00:00:00
abstract::ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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doi:10.1177/000456328402100203
更新日期:1984-03-01 00:00:00
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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更新日期:2004-03-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:1989-05-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1258/0004563021901874
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Measurement of HbA(1c) is the standard test for assessment of glycaemic control in diabetic subjects. Using new glucose sensing technology we re-evaluated the significance of HbA(1c) in terms of the aspects of the blood profile it measures in patients with diabetes. METHODS:In a group of 27 patients with ty...
journal_title:Annals of clinical biochemistry
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更新日期:2002-09-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:1985-05-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:2017-01-01 00:00:00
abstract::We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic ch...
journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00