Pharmacological heterogeneity among calcium channels that subserve acetylcholine release in vertebrate forebrain.

abstract：:The reported effects of nitric oxide (NO) on dopamine release from the striatum are variable and its precise effect on striatal nerve terminals is unclear. In the present study a novel method of applying NO to brain tissue in situ was employed. Photo-activation of Roussin's Black Salt (RBS), retained in isolated perfu...

journal_title：Neuropharmacology

authors： Black MD,Matthews EK,Humphrey PP

更新日期：1994-11-01 00:00:00

abstract：:Previous reports have shown that activation of N-methyl-D-aspartate (NMDA) receptors potentiates responses to activation of the group I metabotropic glutamate receptor mGluR5 by reversing PKC-mediated desensitization of this receptor. NMDA-induced reversal of mGluR5 desensitization is dependent on activation of protei...

journal_title：Neuropharmacology

authors： Alagarsamy S,Saugstad J,Warren L,Mansuy IM,Gereau RW 4th,Conn PJ

更新日期：2005-01-01 00:00:00

abstract：:Depotentiation, the reversal of long-term potentiation (LTP), can be induced by activation of metabotropic glutamate receptors (mGluRs) or NMDA receptors (NMDARs). Although NMDAR-dependent depotentiation is due to a protein phosphatase-dependent erasure of LTP, the notion that mGluR-dependent depotentiation also invol...

journal_title：Neuropharmacology

authors： Delgado JY,O'dell TJ

更新日期：2005-06-01 00:00:00

abstract：:Tolcapone and entacapone are catechol-O-methyltransferase (COMT) inhibitors used as adjuncts to levodopa in the treatment of Parkinson's disease (PD). The use of tolcapone has been limited by its hepatotoxicity, the cause of which remains uncertain. Tolcapone compound is an uncoupler of mitochondrial respiration in is...

journal_title：Neuropharmacology

authors： Korlipara LV,Cooper JM,Schapira AH

更新日期：2004-03-01 00:00:00

abstract：:YM992, (S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride, exhibited the biochemical profile of a selective serotonin (5-HT) reuptake inhibitor (SSRI) with 5-HT2A receptor antagonistic activity. YM922 showed the same high affinity as fluoxetine against the 5-HT reuptake site (Ki = 21 nM) and a similar...

journal_title：Neuropharmacology

authors： Hatanaka K,Nomura T,Hidaka K,Takeuchi H,Yatsugi S,Fujii M,Yamaguchi T

更新日期：1996-01-01 00:00:00

abstract：:Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

journal_title：Neuropharmacology

authors： Fields DP,Mitchell GS

更新日期：2017-02-01 00:00:00

abstract：:Benzodiazepine drugs (BZ) are used for anxiety, insomnia, and seizures. They worsen memory, especially in large doses, but the mechanism of this action is uncertain. In micromolar concentrations, benzodiazepines have been shown to reduce long-term potentiation (LTP), which could be a cellular basis for their amnesic a...

journal_title：Neuropharmacology

authors： Evans MS,Viola-McCabe KE

更新日期：1996-03-01 00:00:00

abstract：:Extrapyramidal syndromes (EPS) caused by antipsychotic therapy are currently treated with anticholinergics that lack selectivity for the five muscarinic receptor subtypes. Since these receptors are heterogeneously expressed among the different classes of striatal neurons and their afferents, it can be expected that th...

journal_title：Neuropharmacology

authors： Erosa-Rivero HB,Bata-García JL,Alvarez-Cervera FJ,Heredia-López FJ,Góngora-Alfaro JL

更新日期：2014-06-01 00:00:00

abstract：:A genetic component is associated with the development of many forms of epilepsy. Recently, mutations in the GABAA receptor have been linked to several inherited epilepsies. One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit. To determine...

journal_title：Neuropharmacology

authors： Fisher JL

更新日期：2004-04-01 00:00:00

abstract：:A range of antipsychotic drugs, both "typical" and "atypical", was administered to rats over a time course and at several different dosages. The mRNA levels of dopamine D1, D2 and D3 receptor were measured in either whole brain or dissected brain regions. D3 receptor mRNA was up-regulated in whole brain by clozapine (...

journal_title：Neuropharmacology

authors： D'Souza U,McGuffin P,Buckland PR

更新日期：1997-11-01 00:00:00

abstract：:Most current pharmacologic antidepressant treatments target monoaminergic systems confronts some problems such as low rate of remission and high risk for relapse indicating new therapeutic strategy is urgently need. Evidences showed that impairments in mitochondrial function were associated with the pathogenesis of mo...

journal_title：Neuropharmacology

authors： Yang N,Ren Z,Zheng J,Feng L,Li D,Gao K,Zhang L,Liu Y,Zuo P

更新日期：2016-06-01 00:00:00

abstract：:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administrati...

journal_title：Neuropharmacology

authors： Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

更新日期：1988-08-01 00:00:00

abstract：:The effects of injection of the thyrotrophin-releasing hormone (TRH) analogue, orotyl-histidyl-proline amide (CG3509) into the accumbens and striatum, was studied on dopamine metabolism by means of in vivo voltammetry. Forty minutes after infusion of CG3509 (1-5 micrograms) into the n. accumbens there was a significan...

journal_title：Neuropharmacology

authors： Sharp T,Brazell MP,Bennett GW,Marsden CA

更新日期：1984-06-01 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:The guinea-pig substantia nigra receives a 5-hydroxytryptaminergic (5-HT ergic) projection from the dorsal raphé nucleus. In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically ...

journal_title：Neuropharmacology

authors： Dickie BG,Greenfield SA

更新日期：1995-09-01 00:00:00

abstract：:Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasticity and enhance cognition. However, the impact of exercise initiated...

journal_title：Neuropharmacology

authors： O'Leary JD,Hoban AE,Cryan JF,O'Leary OF,Nolan YM

更新日期：2019-02-01 00:00:00

abstract：:Venlafaxine, a novel 2-phenyl-2-(1-hydroxycycloalkyl) ethylamine, is a potent inhibitor of 5-hydroxytryptamine and noradrenaline reuptake and exhibits a profile of activity in pre-clinical in vitro biochemical studies predictive of antidepressant activity. The studies described here examined the effects of acute and c...

journal_title：Neuropharmacology

authors： Mitchell PJ,Fletcher A

更新日期：1993-10-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:The effect of sumatriptan, a selective 5-HT1D receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by intracerebral dialysis. A constant infusion of sumatriptan (10(-8)-10(-7) M) dose-dependently reduced extracellular levels of 5-HT (e.g. 80 +/- 2% decrease from control ...

journal_title：Neuropharmacology

authors： Sleight AJ,Cervenka A,Peroutka SJ

更新日期：1990-06-01 00:00:00

abstract：:Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes, but their presence in hippocampal pyramidal neurons remains elusive. Here we find that in CA1 pyramidal neurons a slow EPSC is induced by repetitive stimulation w...

journal_title：Neuropharmacology

authors： Sheng N,Yang J,Silm K,Edwards RH,Nicoll RA

更新日期：2017-03-15 00:00:00

abstract：:SKF 83959 that has a unique antiparkinson profile in animal models of Parkinson's disease is an in vitro dopamine D1 antagonist of receptors coupled to adenylyl cyclase. We hypothesized that SKF 83959, among others, interacts with dopamine D1 receptors coupled to adenylyl cyclase in the nucleus accumbens and the prefr...

journal_title：Neuropharmacology

authors： Cools AR,Lubbers L,van Oosten RV,Andringa G

更新日期：2002-02-01 00:00:00

abstract：:The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

journal_title：Neuropharmacology

authors： Bot G,Chahl LA,Brent PJ,Johnston PA

更新日期：1992-09-01 00:00:00

abstract：:We have examined the regulation of neuronal nitric oxide synthase (NOS) by phosphorylation with cyclic-GMP (PKG) and cyclic-AMP-dependent (PKA) protein kinases. In vitro phosphorylation studies indicate that both PKG and PKA phosphorylate NOS on a single site. Phosphoamino-acid analysis and peptide mapping demonstrate...

journal_title：Neuropharmacology

authors： Dinerman JL,Steiner JP,Dawson TM,Dawson V,Snyder SH

更新日期：1994-11-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) acts in brain by binding to GABAA/benzodiazepine receptors (GBR) and to mitochondrial benzodiazepine receptors (MBR). Because DBI acting at MBR, has been shown to be an effector of ACTH-induced steroidogenesis and stress is known to change the level of GBR and MBR, the model of acute n...

journal_title：Neuropharmacology

authors： Ferrarese C,Mennini T,Pecora N,Pierpaoli C,Frigo M,Marzorati C,Gobbi M,Bizzi A,Codegoni A,Garattini S

更新日期：1991-12-01 00:00:00

abstract：:Thyroid hormone deficiency during early developmental stages causes a multitude of functional and morphological deficits in the brain. In the present study we investigate the effects of a mutated thyroid hormone receptor TR alpha 1 and the resulting receptor-mediated hypothyroidism on the development of GABAergic neur...

journal_title：Neuropharmacology

authors： Hadjab-Lallemend S,Wallis K,van Hogerlinden M,Dudazy S,Nordström K,Vennström B,Fisahn A

更新日期：2010-06-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) receptor-expressing (GRPR)+ neurons have a central role in the spinal transmission of itch. Because their fundamental regulatory mechanisms are not yet understood, it is important to determine how such neurons are excited and integrate itch sensation. In this study, we investigated the ...

journal_title：Neuropharmacology

authors： Kiguchi N,Uta D,Ding H,Uchida H,Saika F,Matsuzaki S,Fukazawa Y,Abe M,Sakimura K,Ko MC,Kishioka S

更新日期：2020-06-15 00:00:00

abstract：:In this study, the role of CB₂r on aversive memory consolidation was further evaluated. Mice lacking CB₂r (CB2KO) and their corresponding littermates (WT) were exposed to the step-down inhibitory avoidance test (SDIA). MAP2, NF200 and synaptophysin (SYN)-immunoreactive fibers were studied in the hippocampus (HIP) of b...

journal_title：Neuropharmacology

authors： García-Gutiérrez MS,Ortega-Álvaro A,Busquets-García A,Pérez-Ortiz JM,Caltana L,Ricatti MJ,Brusco A,Maldonado R,Manzanares J

更新日期：2013-10-01 00:00:00

abstract：:The ability of (-)N-n-propylnorapomorphine and selective D1 and D2 dopamine receptor agonists and antagonists to modify the release of [3H]dopamine, induced by potassium from the nucleus accumbens, was studied using an in vitro superfusion technique. (-)N-n-Propylnorapomorphine, in picomolar concentrations, inhibited ...

journal_title：Neuropharmacology

authors： Barnes JM,Barnes NM,Costall B,Naylor RJ

更新日期：1990-04-01 00:00:00

abstract：:The 15q25 gene cluster contains genes that code for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChRs) subunits, and in human genetic studies, has shown the most robust association with smoking behavior and nicotine dependence to date. The limited available animal studies implicate a role for the α5 and β4 n...

journal_title：Neuropharmacology

authors： Jackson KJ,Sanjakdar SS,Muldoon PP,McIntosh JM,Damaj MI

更新日期：2013-07-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. Using rat striatal synaptosomes loaded with [3H]dopamine, we have characterized the action of the selective nicotinic agonist, (+/-)anatoxin-a, with respect to [3H]dopamine release, in order to explore the mecha...

journal_title：Neuropharmacology

authors： Soliakov L,Gallagher T,Wonnacott S

更新日期：1995-11-01 00:00:00