Abstract:
:Generalized epilepsy with febrile seizures plus (GEFS+) is a clinically and genetically heterogeneous syndrome with childhood onset, characterized by febrile seizures (FS) and a variety of afebrile epileptic seizure types. The authors performed a mutational analysis of SCN1B on 74 unrelated probands with GEFS+, FS, or FS plus (FS+). In a family with FS+ and early-onset absence epilepsy, a mutation was identified that predicts a deletion of five amino acids in the extracellular immunoglobulin-like domain of SCN1B and potential loss of function. SCN1B mutations are associated with GEFS+ and may have a role in the elicitation of absence seizures.
journal_name
Neurologyjournal_title
Neurologyauthors
Audenaert D,Claes L,Ceulemans B,Löfgren A,Van Broeckhoven C,De Jonghe Pdoi
10.1212/01.wnl.0000080362.55784.1csubject
Has Abstractpub_date
2003-09-23 00:00:00pages
854-6issue
6eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
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