Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.

Abstract:

:Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates has been reported in patients who receive a prolonged course of the drug. We report two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who previously received linezolid for infections with vancomycin-resistant Enterococcus faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S rRNA correlated with the level of resistance.

authors

Ruggero KA,Schroeder LK,Schreckenberger PC,Mankin AS,Quinn JP

doi

10.1016/s0732-8893(03)00153-6

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

511-3

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732889303001536

journal_volume

47

pub_type

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