Abstract：
OBJECTIVE:This study examined 1H MRS detected metabolite levels (in left frontal, temporal lobes and thalamus) and clinical and cognitive features of patients with first-episode and chronic schizophrenia. METHOD:We studied 31 first-episode patients (group 1) and 17 chronic patients (group 2) with ICD-10 diagnosis of schizophrenia (and 13 healthy subjects). Patients were also assessed by the means of PANSS, CGI, Calgary scales and WCST, TMT, Stroop tests. RESULTS:We did not observe statistically significant differences in metabolite levels between group 1 and 2. We observed only a trend toward higher Cho level in temporal lobe in group 2 and lower NAA level in group 1. When comparing with the control group we observed a significantly higher Cho level in the frontal lobe (group 1,2) (p < 0.05). We observed a trend toward lower NAA levels in the frontal lobe (group 1,2), and lower NAA level in the temporal lobe (group 1). Patients with chronic schizophrenia performed significantly worse in WCST, TMT and Stroop tests (p < 0.05). CONCLUSION:These results suggest, that abnormalities in metabolite levels in frontal and temporal lobes are present at the onset of disease and don't progress over time. The cognitive dysfunction is more prominent in chronic patients.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Szulc A,Galińska B,Tarasów E,Walecki J,Dzienis W,Kubas B,Czernikiewicz Asubject
Has Abstractpub_date
2003-11-01 00:00:00pages
977-88issue
6eissn
0033-2674issn
2391-5854journal_volume
37pub_type
杂志文章abstract：:The paper discusses the controversy surrounding the medical ethics code. It was noticed that there exists a lack of a psychiatric regulation in the law. Also, considered were the dangers for the patient associated with the low tolerance of the society and with the reform of the health care system. Historic cases of ab...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:On the basis of analyzed clinical material several observations were attempted which were related to the patients' awareness of one's own affective psychosis. It was discovered that patients with endogenous depression considered themselves to be ill, but only in relation to depression. They usually do not perceive in ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：1992-05-01 00:00:00
abstract：:Medical documentation of 674 elderly patients of gerontopsychiatric department was studied in order to estimate the frequency of physical aggression in relation to sex, diagnosis of dementia and other psychiatric disorders. This form of aggression was found significantly more often in men (52%) than in women (32%). Th...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the supply of selected vitamins and minerals in the daily food rations of patients diagnosed with schizophrenia. METHODS:62 schizophrenia patients (32 women and 30 men aged 21-64, the mean age of women was 41.3 ± 11.2, the mean age of men was 36.1 ± 9.7) took part in the s...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/92280
更新日期：2019-06-30 00:00:00
abstract：AIM:To evaluate the efficacy of cognitive behavioral therapy (CBT-I) in chronic insomnia treatment. METHOD:236 patients with ICD- 10 nonorganic insomnia were assigned to group CBT-I (6 sessions, 6-10 patients). From this pool, 72 participants with no history of other psychiatric or sleep disorders conditions were sele...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Three cases of psychic disorders in the course of Lyme borreliosis were described. Two cases were connected with Lyme meningitis, one of them with chronic Lyme arthritis. These cases were described to discuss the possible occurrence of mental disturbances in the course of Lyme borreliosis, directly or indirectly conne...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:This article presents a review of the interactions between zinc and glutamate system in the pathophysiology and treatment of depression. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2001-03-01 00:00:00
abstract：:A group of 107 patients with diagnosis of syndromological dilusional psychosis underwent a catamnestic examination after 11.2 years from contracting the disease (8.7 years after the first hospitalization). During the first hospitalization with application of different criteria, the dependence of the early (clinical im...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Second generation antipsychotics share some similarities but display also differences in their action. The pharmacological profile as well as the clinical efficacy and tolerability of these drugs currently on the market in Poland have been described. The analysis of their properties reveals distinct differences betwee...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmunologic illness, which apart from changes in the skin, the locomotor system and the internal organs, attacks also the nervous system. The paper presents 19 neuropsychiatric symptomic syndromes which after conduction of multidisciplinary, international research were acce...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:The aim of the study was to assess the effectiveness of psychotherapy in patients with a diagnosis of schizophrenia in a day hospital. The presented model is based on the combination of group psychotherapy, individual psychotherapy and pharmacotherapy with respect to the individual needs of a patient. Psychotherapy wa...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Advancement in research on glication process in pathogenesis of AD is presented. Its results may open new, promising possibilities of treatment of neurodegenerative diseases including AD with inhibitors of glication. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:The paper describes a specific form of Oedipus complex that may occur as a result of sexual abuse. The author emphasises that formation of the image of one parent due to actual sexual abuse and the activity of the child's (patient's) own iscestual impulses causes that the second parent is experienced as a terrorizing ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Having the opportunity to work has been found meaningful for individuals suffering from severe mental illness, in order to boost their self-esteem, provide a sense of control over their lives and of belonging to a community. There are no studies in Polish literature on the process of recovery from schizophre...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/44238
更新日期：2016-01-01 00:00:00
abstract：:The paper presents a critical review regarding the pathogenesis of schizophrenia. The neurodevelopmental theory which is now mostly recognized, needs some explanations, some elements of neurodegenerative theory are revisited. The developmental factors are confirmed as important in the pathogenesis of schizophrenia, bu...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:A polish translation and the description of the clinical use of the novel screening tool in Alzheimer's disease, a "7 Minute Screen", is presented. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:This article discusses biochemical changes of ethyl alcohol in human organism, concentrating especially on the negative influence on the metabolism of liver. The authors describe the process of oxidation of alcohol with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) and emphasize the role of ADH i ALDH ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Neuropsychiatric symptoms are commonly related to interferon alpha treatment. The paper summarises the current knowledge about their aetiology, course, and treatment. Interferon alpha is a cytokine with antiviral and antineoplasmatic activity. It is commonly used in the treatment of chronic hepatitis C and B, malignan...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:The aim of the presented study was to analyse associations between drug-resistant depression and the way the illness is described by patients and members of their families. In particular, a hypothesis to be verified was that being ill may be a factor stabilising the family system, and consequently treatment ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/39750
更新日期：2018-06-30 00:00:00
abstract：:Phototherapy was administered to three female outpatients with seasonal affective disorder (winter depression), according to the DSM III-R criteria. The intensity of light was about 2.500 lux in two, and 1.500 lux in one cases at the eyes level. The treatment has shown to be very effective. Antidepressant response was...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVES:Research results indicate that possibility of building a therapeutic relationship in schizophrenia treatment facilitates better functioning, more effective reduction in psychotic symptoms and fulfillment of patients' personal goals. The aim of the present study was to investigate whether patients systematica...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/31505
更新日期：2015-03-01 00:00:00
abstract：:There is growing interest in the role of Dehydroepiandrosteron (DHEA) in depression. To evaluate the validity of its administration in depression, the role of DHEA in the mechanism of depression and cardiovascular risk, as so the results of clinical trials must be considered. According to accessible literature, both c...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-05-01 00:00:00
abstract：:Plasma cortisol level was measured 7 times between 3 and 5 pm in 34 inpatients with major depression and 25 controls. 1 mg of dexamethasone per os was administrated the day before a 11 pm. The maximum, minimum, mean and range of cortisol concentration were calculated. All these parameters were statistically significan...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVES:Internet Addiction Disorder can be defined as "the inability of individuals to control their internet use, resulting in marked distress and/or functional impairment in daily life." It carries the same social aftermath of impulse control and substance misuse disorders such as loss of control, craving and with...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/32500
更新日期：2015-03-01 00:00:00
abstract：:no summary. ...
journal_title：Psychiatria polska
pub_type： 社论
doi：10.12740/PP/74146
更新日期：2017-06-18 00:00:00
abstract：:In this paper we review previous research, suggesting a link between depressive symptoms and poor prognosis in cancer patients. The possibility, to identify an association between depressed mood and poorer outcomes and survival in haematological malignancies seems to be very interesting. We shortly describe acute leuk...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:The aim of the work was to establish the usefulness of alcoholism scales enclosed in MMPI for the evaluation of risk of alcohol dependence among college students. The results of 1255 college students from different schools and various years of studium were reviewed. The risk of alcohol dependence was established by an...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：UNLABELLED:A pair of auditory stimuli presented in a 0.5 second interval cause a reduction of the P50 auditory evoked potential (P50 AEP) amplitude after the second stimuli in the pair. In some, but not all studies, a clear deficit of such P50 AEP gating was observed in schizophrenic patients. It was present constantly...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:Computerized tomography of the head and psychological evaluation by use the WAIS, Benton Gestalt Test, and L. Bender battery was performed in 32 bipolar patients. CT revealed structural changes in 90% of subjects while only 47% of patients showed organic features in psychological evaluation. No significant correlation...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：INTRODUCTION:The influence of antipsychotic medication on brain alterations in proton magnetic resonance spectroscopy (1H MRS) in schizophrenia can be the explanation of many discrepancies observed in the previous papers. AIM:The aim of this study was the evaluation of antipsychotic medication effect on the metabolite...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
