A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection.

abstract：:Influenza causes significant morbidity in tropical regions; however, unlike in temperate zones, influenza in the tropics is not strongly associated with a given season. We have recently shown that influenza virus transmission in the guinea pig model is most efficient under cold, dry conditions, which are rare in the t...

journal_title：Journal of virology

authors： Lowen AC,Steel J,Mubareka S,Palese P

更新日期：2008-06-01 00:00:00

abstract：:The secreted cytokine alpha/beta interferon (IFN-alpha/beta) binds its receptor to activate the Jak-STAT signal transduction pathway, leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an antiviral stat...

journal_title：Journal of virology

authors： Zurney J,Kobayashi T,Holm GH,Dermody TS,Sherry B

更新日期：2009-03-01 00:00:00

abstract：:Infection of the central nervous system (CNS) by several viruses can lead to upregulation of proinflammatory cytokines and chemokines. In immunocompetent adults, these molecules induce prominent inflammatory infiltrates. However, with immunosuppressive retroviruses, such as human immunodeficiency virus (HIV), little C...

journal_title：Journal of virology

authors： Peterson KE,Robertson SJ,Portis JL,Chesebro B

更新日期：2001-03-01 00:00:00

abstract：:Nine pre-early polypeptides have been detected after infection with bacteriophage T5 and 10 pre-early polypeptides have been detected after infection with bacteriophage BF23. Only about one-half of the coding capacity of the redundant ends of the phage DNA, which code for pre-early proteins, is needed for these 9 to 1...

journal_title：Journal of virology

authors： McCorquodale DJ,Shaw AR,Shaw PK,Chinnadurai G

更新日期：1977-05-01 00:00:00

abstract：:Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cell...

journal_title：Journal of virology

authors： Lagaye S,Derrien M,Menu E,Coïto C,Tresoldi E,Mauclère P,Scarlatti G,Chaouat G,Barré-Sinoussi F,Bomsel M,European Network for the Study of In Utero Transmission of HIV-1.

更新日期：2001-05-01 00:00:00

abstract：:Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about ...

journal_title：Journal of virology

authors： Espejo RT,López S,Arias C

更新日期：1981-01-01 00:00:00

abstract：:The E5 protein of human papillomavirus type 16 is a small, hydrophobic protein that localizes predominantly to membranes of the endoplasmic reticulum (ER). To define the orientation of E5 in these membranes, we employed a differential, detergent permeabilization technique that makes use of the ability of low concentra...

journal_title：Journal of virology

authors： Krawczyk E,Suprynowicz FA,Sudarshan SR,Schlegel R

更新日期：2010-02-01 00:00:00

abstract：:Sequencing and reversion analysis of murine hepatitis virus (MHV) temperature-sensitive (ts) viruses has identified putative ts mutations in the replicase nonstructural proteins (nsp's) of these coronaviruses. In this study, reverse transcriptase PCR sequencing of the RNA genome of an isolate of the MHV ts virus Alb t...

journal_title：Journal of virology

authors： Sparks JS,Donaldson EF,Lu X,Baric RS,Denison MR

更新日期：2008-06-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：:VP16-H is an essential structural protein of herpes simplex virus type 1 (HSV-1) and is also a potent activator of virus immediate-early (IE) gene expression. Current models of functional determinants within VP16-H indicate that it consists of two domains, an N-terminal domain involved in recruiting VP16-H to a multic...

journal_title：Journal of virology

authors： Grapes M,O'Hare P

更新日期：2000-11-01 00:00:00

abstract：UNLABELLED:Many coxsackievirus B (CVB) isolates bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR). However, the virus does not interact with murine DAF. To understand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in whi...

journal_title：Journal of virology

authors： Pan J,Zhang L,Organtini LJ,Hafenstein S,Bergelson JM

更新日期：2015-01-15 00:00:00

abstract：:Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in both strands. Upon infectious entry into a host cell, this genome is converted into a covalently closed superhelical form (CCC-DNA), which later serves as the template for transcription. Here we examined whether the viral polymerase ...

journal_title：Journal of virology

authors： Köck J,Schlicht HJ

更新日期：1993-08-01 00:00:00

abstract：UNLABELLED:Neutralizing antibodies that target the hemagglutinin of influenza virus either inhibit binding of hemagglutinin to cellular receptors or prevent the low-pH-induced conformational change in hemagglutinin required for membrane fusion. In general, the former type of antibody binds to the globular head formed b...

journal_title：Journal of virology

authors： Iba Y,Fujii Y,Ohshima N,Sumida T,Kubota-Koketsu R,Ikeda M,Wakiyama M,Shirouzu M,Okada J,Okuno Y,Kurosawa Y,Yokoyama S

更新日期：2014-07-01 00:00:00

abstract：:Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular localizati...

journal_title：Journal of virology

authors： Pancio HA,Vander Heyden N,Ratner L

更新日期：2000-07-01 00:00:00

abstract：:Polydnaviridae is a unique family of DNA viruses that are symbiotically associated with parasitoid wasps. Upon oviposition, wasps inject these viruses into their hosts, where they cause several physiological alterations, including suppression of the cellular immune response. Here we report that expression of the glc1....

journal_title：Journal of virology

authors： Beck M,Strand MR

更新日期：2005-02-01 00:00:00

abstract：:The fraction of the adenovirus type 5 genome expressed as mRNA in a rat cell line, 5RK, transformed by the HsuI-G restriction fragment was analyzed by saturation hybridization using separated strands of 32P-labeled HindIII-G fragment. It was found that 45 to 50% of G fragment (about 8 X 10(5) daltons) is expressed as ...

journal_title：Journal of virology

authors： Chinnadural G,Fujinaga K,Rho MH,van der Eb AJ,Green M

更新日期：1978-12-01 00:00:00

abstract：:We have examined the pattern of RNA transcription on the L (late) DNA strand late in the simian virus 40 virus infectious cycle by separating pulse-labeled RNA chains according to size and hybridizing to an ordered series of DNA fragments obtained by restriction enzyme digestion. From this analysis, the 5' end of the ...

journal_title：Journal of virology

authors： Ford JP,Hsu MT

更新日期：1978-12-01 00:00:00

abstract：:Nucleocapsids were isolated from purified enveloped nucleocapsids of Plodia interpunctella granulosis virus by treatment with Nonidet P-40. When analyzed on sodium dodecyl sulfate-polyacrylamide gels, the nucleocapsids consisted of eight polypeptides. One of these, a major component with a molecular weight of 12,500 (...

journal_title：Journal of virology

authors： Tweeten KA,Bulla LA,Consigli RA

更新日期：1980-02-01 00:00:00

abstract：:The genome of hepatitis A virus (HAV) was reverse transcribed into cDNA and molecularly cloned. cDNA clones coding for the capsid protein VP1 that carries the major HAV antigen were cloned into the expression vector pUR290 and expressed in Escherichia coli. The recombinant fusion protein reacted in an immunoblot with ...

journal_title：Journal of virology

authors： Ostermayr R,von der Helm K,Gauss-Müller V,Winnacker EL,Deinhardt F

更新日期：1987-11-01 00:00:00

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...

journal_title：Journal of virology

authors： Gretch DR,Kari B,Gehrz RC,Stinski MF

更新日期：1988-06-01 00:00:00

abstract：:Epstein-Barr virus is associated with several human malignancies including Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease (HD). To examine the effect of Epstein-Barr virus nuclear antigen 1 (EBNA-1) in the pathogenesis of HD, we transfected the gene into the HD cell line L428. EBNA-1 expression wa...

journal_title：Journal of virology

authors： Kube D,Vockerodt M,Weber O,Hell K,Wolf J,Haier B,Grässer FA,Müller-Lantzsch N,Kieff E,Diehl V,Tesch H

更新日期：1999-02-01 00:00:00

abstract：:A protein-protein interaction within the helicase domain of the Tobacco mosaic virus (TMV) 126- and 183-kDa replicase proteins was previously implicated in virus replication (S. Goregaoker, D. Lewandowski, and J. Culver, Virology 282:320-328, 2001). To further characterize the interaction, polypeptides covering the in...

journal_title：Journal of virology

authors： Goregaoker SP,Culver JN

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments. Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a...

journal_title：Journal of virology

authors： Poo YS,Nakaya H,Gardner J,Larcher T,Schroder WA,Le TT,Major LD,Suhrbier A

更新日期：2014-06-01 00:00:00

abstract：:We have investigated the species-specific replication of polyomavirus DNA in the cell-free system that was established previously (Y. Murakami, T. Eki, M. Yamada, C. Prives, and J. Hurwitz, Proc. Natl. Acad. Sci. USA 83:6347-6351, 1986). Extracts from various species of cells supported polyomavirus DNA replication in ...

journal_title：Journal of virology

authors： Eki T,Enomoto T,Masutani C,Miyajima A,Takada R,Murakami Y,Ohno T,Hanaoka F,Ui M

更新日期：1991-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein US2 increases the proteasome-mediated degradation of major histocompatibility complex (MHC) class I heavy chain (HC), class II DR-alpha and DM-alpha proteins, and HFE, a nonclassical MHC protein. US2-initiated degradation of MHC proteins apparently involves the recruitment of ...

journal_title：Journal of virology

authors： Chevalier MS,Johnson DC

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication. HIV-1 Vpr and HIV-2/simian immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteaso...

journal_title：Journal of virology

authors： Sharifi HJ,Furuya AK,Jellinger RM,Nekorchuk MD,de Noronha CM

更新日期：2014-06-01 00:00:00

abstract：:Cycloheximide and 6-azauridine were employed to study the time course of measles virus protein and nucleic acid syntheses in AV3 cells. Synthesis of ribonucleic acid (RNA) essential for infectivity was first detected at 6 hr and increased concurrently with the formation of essential protein. Maximum levels of virus-sp...

journal_title：Journal of virology

authors： Portner A,Bussell RH

更新日期：1973-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) subtype C viruses have been found to almost exclusively use the chemokine receptor CCR5 as a coreceptor for entry, even in patients with advanced AIDS. We have characterized subtype C virus isolates from 28 patients from Harare, Zimbabwe, 20 of whom were receiving antiretrov...

journal_title：Journal of virology

authors： Johnston ER,Zijenah LS,Mutetwa S,Kantor R,Kittinunvorakoon C,Katzenstein DA

更新日期：2003-07-01 00:00:00

abstract：:Antibodies present in two peritoneal exudates of rats bearing abdominal tumors induced by UR2-transformed rat cells were characterized. The ability to immunoprecipitate p68gag-ros and to inhibit the protein and phospholipid kinase activities of this protein was investigated. One of the exudates specifically inhibited ...

journal_title：Journal of virology

authors： Balduzzi PC,Chovav M,Christensen JR,Macara IG

更新日期：1986-11-01 00:00:00