Expression of hepatitis A virus cDNA in Escherichia coli: antigenic VP1 recombinant protein.

abstract：:A herpes simplex virus type 1 variant [C239(TK-)] harboring a deletion in the thymidine kinase (TK) gene was assessed for capacity to establish latent infections. Outbred Swiss Webster mice were inoculated on both hind footpads, and numbers of neurons expressing latency-associated transcript and amounts of viral DNA i...

journal_title：Journal of virology

authors： Leist TP,Sandri-Goldin RM,Stevens JG

更新日期：1989-11-01 00:00:00

abstract：:Systemic application of first-generation adenovirus induces pathogenic effects in the liver. To begin unraveling the mechanisms underlying early liver toxicity after adenovirus infusion, particularly the role of macrophage activation and expression of viral genes in transduced target cells, first-generation adenovirus...

journal_title：Journal of virology

authors： Lieber A,He CY,Meuse L,Schowalter D,Kirillova I,Winther B,Kay MA

更新日期：1997-11-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific rol...

journal_title：Journal of virology

authors： Scheffer KD,Gawlitza A,Spoden GA,Zhang XA,Lambert C,Berditchevski F,Florin L

更新日期：2013-03-01 00:00:00

abstract：:Influenza A virus (IAV) replication relies on an intricate interaction between virus and host cells. How the cellular proteins are usurped for IAV replication remains largely obscure. The aim of this study was to search for novel and potential cellular factors that participate in IAV replication. ZBTB25, a transcripti...

journal_title：Journal of virology

authors： Chen SC,Jeng KS,Lai MMC

更新日期：2017-09-27 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a variety of immunoregulatory disorders. HTLV-1 has been shown to bind to and infect a variety of hematopoietic and nonhematopoietic cells. However, both in vivo and in vitro, the provirus is mos...

journal_title：Journal of virology

authors： Newbound GC,Andrews JM,O'Rourke JP,Brady JN,Lairmore MD

更新日期：1996-04-01 00:00:00

abstract：:The Sindbis virus minimal subgenomic mRNA promoter (spanning positions -19 to +5 relative to the subgenomic mRNA start site) is approximately three- to sixfold less active than the fully active -98 to +14 promoter region. We identified two elements flanking the -19 to +5 region which increase its transcription to leve...

journal_title：Journal of virology

authors： Wielgosz MM,Raju R,Huang HV

更新日期：2001-04-01 00:00:00

abstract：:The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...

journal_title：Journal of virology

authors： Spaderna S,Kropff B,Ködel Y,Shen S,Coley S,Lu S,Britt W,Mach M

更新日期：2005-09-01 00:00:00

abstract：:We previously reported that a mutant Rous sarcoma virus (RSV) with an alternate polypurine tract (PPT), DuckHepBFlipPPT, had unexpectedly high titers and that the PPT was miscleaved primarily at one position following a GA dinucleotide by the RNase H of reverse transcriptase (RT). This miscleavage resulted in a portio...

journal_title：Journal of virology

authors： Chang KW,Oh J,Alvord WG,Hughes SH

更新日期：2008-09-01 00:00:00

abstract：:The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming abilit...

journal_title：Journal of virology

authors： Gazdar AF,Russell E,Sarma PS,Sarin PS,Hall W,Chopra HC

更新日期：1973-10-01 00:00:00

abstract：:A particles with the diameter of 70 to 80 nm were isolated from the cytoplasm of HEp-2, HeLa, and AO cells producing oncornavirus of Mason-Pfizer-like type. Most of the A particles banded at 1.23 to 1.24 g/ml, whereas 3 to 10% banded at 1.29 g/ml in equilibrium sucrose gradients. They banded at 1.30 g/ml in CsCl gradi...

journal_title：Journal of virology

authors： Bukrinskaya AG,Miller GG,Lebedeva EN,Agaphonova LV,Masurenko NN,Ilyin KV

更新日期：1974-10-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) infection in the central nervous system (CNS) is characterized by replication in macrophages or brain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia and related cognitive and motor disorders that affect 20 to 30% o...

journal_title：Journal of virology

authors： Zhuang K,Leda AR,Tsai L,Knight H,Harbison C,Gettie A,Blanchard J,Westmoreland S,Cheng-Mayer C

更新日期：2014-08-01 00:00:00

abstract：:A unique feature of the large hepadnavirus envelope protein (L) is its mixed transmembrane topology, resulting from partial posttranslational translocation of the pre-S domain. Using protease protection analysis, we demonstrate for duck hepatitis B virus an essential role for the small envelope protein (S) in this pro...

journal_title：Journal of virology

authors： Grgacic EV,Kuhn C,Schaller H

更新日期：2000-03-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) establishes a latent infection in sensory ganglionic neurons of cattle. During a latent infection, a single latency-related (LR) transcript is expressed. This observation suggested that DNA sequences in the LR promoter are positively regulated by neural cell type factors. The regulation of...

journal_title：Journal of virology

authors： Bratanich AC,Jones CJ

更新日期：1992-10-01 00:00:00

abstract：:Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against papillomavirus, a double-stranded DNA virus. By analogy, we reason that polyamid...

journal_title：Journal of virology

authors： Gumpper RH,Li W,Castañeda CH,Scuderi MJ,Bashkin JK,Luo M

更新日期：2018-03-28 00:00:00

abstract：:Incubation of highly purified adeno-associated virus (AAV) capsids in vitro at pH 5.5 induced significant autocleavage of capsid proteins at several amino acid positions. No autocleavage was seen at pH 7.5. Examination of other AAV serotypes showed at least two different pH-induced cleavage patterns, suggesting that d...

journal_title：Journal of virology

authors： Salganik M,Venkatakrishnan B,Bennett A,Lins B,Yarbrough J,Muzyczka N,Agbandje-McKenna M,McKenna R

更新日期：2012-11-01 00:00:00

abstract：:Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasm...

journal_title：Journal of virology

authors： Takemoto KK,Mullarkey MF

更新日期：1973-09-01 00:00:00

abstract：:Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+ T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4+ T-cell proliferation might...

journal_title：Journal of virology

authors： Boritz E,Palmer BE,Wilson CC

更新日期：2004-11-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein B (gB) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. Here we investigated the mechanism of viral neutralization by the monoclonal antibody (MAb) 2c, which specifically recognizes the gB of HSV type 1 (HSV-1) and HSV-2. Bin...

journal_title：Journal of virology

authors： Krawczyk A,Krauss J,Eis-Hübinger AM,Däumer MP,Schwarzenbacher R,Dittmer U,Schneweis KE,Jäger D,Roggendorf M,Arndt MA

更新日期：2011-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates derived directly from clinical samples are usually unable to grow in cytokine-independent continuous cell lines, thus hindering the study of their biological features and their sensitivity to humoral and cellular protective immunity. To overcome these limitations, w...

journal_title：Journal of virology

authors： Lusso P,Cocchi F,Balotta C,Markham PD,Louie A,Farci P,Pal R,Gallo RC,Reitz MS Jr

更新日期：1995-06-01 00:00:00

abstract：:Historically, the adenoviral E3 region was found to be nonessential for viral replication in vitro. In addition, adenoviruses whose genome was more than approximately 105% the size of the native genome were inefficiently packaged. These profound observations were used experimentally to insert transgenes into the adeno...

journal_title：Journal of virology

authors： Zhu M,Bristol JA,Xie Y,Mina M,Ji H,Forry-Schaudies S,Ennist DL

更新日期：2005-05-01 00:00:00

abstract：:Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitations, we identified ...

journal_title：Journal of virology

authors： Joseph SB,Arrildt KT,Swanstrom AE,Schnell G,Lee B,Hoxie JA,Swanstrom R

更新日期：2014-02-01 00:00:00

abstract：:Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectru...

journal_title：Journal of virology

authors： O'Keefe BR,Giomarelli B,Barnard DL,Shenoy SR,Chan PK,McMahon JB,Palmer KE,Barnett BW,Meyerholz DK,Wohlford-Lenane CL,McCray PB Jr

更新日期：2010-03-01 00:00:00

abstract：:Ribonucleic acid extracted from the virions of two human rhinoviruses is infective and is similar in size to poliovirus ribonucleic acid. ...

journal_title：Journal of virology

authors： Nair CN,Lonberg-Holm KK

更新日期：1971-02-01 00:00:00

abstract：:Pathogens such as HIV-1, with their minimalist genomes, must navigate cellular networks and rely on hijacking and manipulating the host machinery for successful replication. Limited overlap of host factors identified as vital for pathogen replication may be explained by considering that pathogens target, rather than s...

journal_title：Journal of virology

authors： Marx A,Alian A

更新日期：2015-05-01 00:00:00

abstract：:The three primary capsid proteins (A, B, and C) of adeno-associated viruses have been shown previously to contain overlapping amino acid sequences (R. McPherson and J. Rose, J. Virol. 46:523-529, 1983). In the present study we demonstrate definitively that these proteins are encoded in the right half of the adeno-asso...

journal_title：Journal of virology

authors： Janik JE,Huston MM,Rose JA

更新日期：1984-11-01 00:00:00

abstract：:Thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. Two research groups independently identified a novel negative-strand RNA virus, now designated avian bornavirus (ABV), in...

journal_title：Journal of virology

authors： Staeheli P,Rinder M,Kaspers B

更新日期：2010-07-01 00:00:00

abstract：:Cells that express glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) resist infection by HSV-1 and HSV-2 because of interference with viral penetration. The results presented here show that both HSV-1 and HSV-2 gD can mediate interference and that various HSV-1 and HSV-2 strains differ in sensitivity to this ...

journal_title：Journal of virology

authors： Dean HJ,Warner MS,Terhune SS,Johnson RM,Spear PG

更新日期：1995-08-01 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high mortality rates in newborn piglets, leading to massive losses to the swine industry worldwide during recent epidemics. Intense research efforts are now focusing on defining viral characteristics that confer a growth advantage, pathogenicity, or cel...

journal_title：Journal of virology

authors： Jaru-Ampornpan P,Jengarn J,Wanitchang A,Jongkaewwattana A

更新日期：2017-01-03 00:00:00