Intratracheal pulmonary ventilation (ITPV): control of positive end-expiratory pressure at the level of the carina through the use of a novel ITPV catheter design.


:A new mode of pulmonary ventilation called intratracheal pulmonary ventilation (ITPV) was studied. Briefly, a continuous flow of air/oxygen is introduced through a small catheter, the tip of which is positioned at the carina, with a diffuser mounted at its distal end. A timed expiration valve, when closed, provides for inspiration; when open, it provides for expiration. The system as first described had a potential for significant back pressure at the level of the carina, which was more at rapid gas flows and with smaller endotracheal tubes. We have now mounted a venturi on the tip of the catheter (reverse thrust catheter [RTC]) that avoids back pressure, and which facilitates expiration. At respiratory rates from 10 to 120/min, the ITPV system with the RTC maintained end-expiratory pressure at the level of the carina at, or near 0 cm H2O. Compared to conventional mechanical ventilation, at identical respiratory rates, this system reduced tidal volume by one half at the lowest respiratory rates, and by as much as two thirds at the highest respiratory rates, with a proportional decrease in peak inspiratory pressure. ITPV has the smallest minute volume ventilation of any conventional or nonconventional mode of pulmonary ventilation.


Anesth Analg


Anesthesia and analgesia


Kolobow T,Powers T,Mandava S,Aprigliano M,Kawaguchi A,Tsuno K,Mueller E




Has Abstract


1994-03-01 00:00:00












  • The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac.

    abstract::Combinations of nonsteroidal antiinflammatory drugs (NSAIDs) and opioids are widespread in the management of pain, allowing better analgesia with reduced side effects. Cannabinoids are promising analgesic drugs that have pharmacological properties similar to those of opioids. However, the beneficial effects of cannabi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ulugöl A,Ozyigit F,Yesilyurt O,Dogrul A

    更新日期:2006-02-01 00:00:00

  • Postoperative Hypotension and Surgical Site Infections After Colorectal Surgery: A Retrospective Cohort Study.

    abstract:BACKGROUND:Hypotension compromises local tissue perfusion, thereby reducing tissue oxygenation. Hypotension might thus be expected to promote infection. Hypotension on surgical wards, while usually less severe than intraoperative hypotension, is common and often prolonged. In this retrospective cohort study, we tested ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yilmaz HO,Babazade R,Leung S,Zimmerman NM,Makarova N,Saasouh W,Stocchi L,Gorgun E,Sessler DI,Turan A

    更新日期:2018-11-01 00:00:00

  • A comparison of remifentanil and sufentanil as adjuvants during sevoflurane anesthesia with epidural analgesia for upper abdominal surgery: effects on postoperative recovery and respiratory function.

    abstract:UNLABELLED:We compared the recovery profile and postoperative SpO(2) after the administration of general anesthesia with either sevoflurane-remifentanil or sevoflurane-sufentanil in 30 healthy patients undergoing upper abdominal surgery. They were randomly allocated to receive general anesthesia with sevoflurane and sm...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Casati A,Albertin A,Fanelli G,Deni F,Berti M,Danelli G,Grifoni F,Torri G

    更新日期:2000-11-01 00:00:00

  • The impact of saline flush of the epidural catheter on resolution of epidural anesthesia in volunteers: a dose-response study.

    abstract:UNLABELLED:We evaluated the effect of 1, 20, and 40 mL of epidural saline flush on recovery from lidocaine epidural anesthesia. Eight volunteers were studied for three study periods, each separated by 72 h. The volume of saline was randomized, and a new catheter was inserted for each study period. A standardized dose o...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chan VW,Nazarnia S,Kaszas Z,Perlas A

    更新日期:1999-10-01 00:00:00

  • The laryngeal mask for percutaneous endoscopic gastrostomy.

    abstract:IMPLICATIONS:We report the successful use of the laryngeal mask airway for percutaneous endoscopic gastrostomy in an adult patient with a known difficult airway and severe cerebral palsy. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Brimacombe J,Newell S,Bergin A,McCarthy J,Barry J

    更新日期:2000-09-01 00:00:00

  • The wolf is crying in the operating room: patient monitor and anesthesia workstation alarming patterns during cardiac surgery.

    abstract:BACKGROUND:Vital sign monitors and ventilator/anesthesia workstations are equipped with multiple alarms to improve patient safety. A high number of false alarms can lead to a "crying wolf" phenomenon with consecutively ignored critical situations. Systematic data on alarm patterns and density in the perioperative phase...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Schmid F,Goepfert MS,Kuhnt D,Eichhorn V,Diedrichs S,Reichenspurner H,Goetz AE,Reuter DA

    更新日期:2011-01-01 00:00:00

  • Influence of volume on the spread of local anesthetic-methylene blue solution after injection for intercostal block.

    abstract::The purpose of this study was to evaluate the influence of the volume of methylene blue-local anesthetic on the spread of the injectate along the costal pleura. Twenty patients undergoing elective thoracotomy were studied. Twelve patients received intercostal nerve injection with 10 mL of 0.5% bupivacaine with methyle...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moorthy SS,Dierdorf SF,Yaw PB

    更新日期:1992-09-01 00:00:00

  • Is transcutaneous electrical stimulation a realistic surrogate for genuine surgical stimulation during spinal anesthesia for cesarean delivery?

    abstract::Several studies have investigated differential block during spinal anesthesia using transcutaneous electrical stimulation (TES) applied to patient's skin. These TES stimuli are claimed to be a surrogate for surgical stimulation, but TES has never been shown to be a realistic surrogate for a surgical stimulus during re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Zaidi AS,Russell IF

    更新日期:2005-05-01 00:00:00

  • The roles of acute and chronic pain in regression of sensory analgesia during continuous epidural bupivacaine infusion.

    abstract::The purpose of this study was to investigate whether regression of sensory analgesia during constant epidural bupivacaine infusion was different in postoperative patients with acute pain than in patients with chronic nonsurgical pain. Sensory levels of analgesia (to pinprick) and pain (on a five-point scale) were asse...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mogensen T,Scott NB,Lund C,Bigler D,Hjortsø NC,Kehlet H

    更新日期:1988-08-01 00:00:00

  • Perioperative management of patients undergoing transsphenoidal pituitary surgery.

    abstract::Pituitary adenomas often present with the symptoms of hormonal hypersecretion, and although medical therapy is available for most hyperfunctioning states, it is not curative. As a result, transsphenoidal pituitary surgery has become a commonly performed neurosurgical procedure with unique challenges for the anesthesio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Nemergut EC,Dumont AS,Barry UT,Laws ER

    更新日期:2005-10-01 00:00:00

  • The division of the sciatic nerve in the popliteal fossa: anatomical implications for popliteal nerve blockade.

    abstract:UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vloka JD,Hadzić A,April E,Thys DM

    更新日期:2001-01-01 00:00:00

  • Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia.

    abstract:UNLABELLED:Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been used to treat rheumatic and osteoarthritic pain and to reduce postoperative pain. Although other NSAIDs, such as indomethacin, reduce cerebral blood flow (CBF), the effect of flurbiprofen on CBF is unknown. In the present study, we investig...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yoshitani K,Kawaguchi M,Tatsumi K,Sasaoka N,Kurumatani N,Furuya H

    更新日期:2004-02-01 00:00:00

  • The vasodilator effects of clevidipine on human internal mammary artery.

    abstract:UNLABELLED:Endothelial dysfunction and platelet activation with thromboxane release may contribute to spasm or alterations in internal mammary artery (IMA) graft flow during coronary artery surgery. Clevidipine, an ultrashort-acting dihydropyridine calcium channel blocker, is undergoing clinical development, but there ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Huraux C,Makita T,Szlam F,Nordlander M,Levy JH

    更新日期:1997-11-01 00:00:00

  • Electroencephalographic burst suppression in elderly and young patients anesthetized with isoflurane.

    abstract::The electroencephalograms of seven elderly (70-85 years) and seven younger patients (23-31 years) anesthetized with a concentration of isoflurane sufficient to produce burst suppression were studied. Anesthesia in these unpremedicated subjects was induced by inhalation of nitrous oxide, isoflurane, and oxygen. Trachea...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Schwartz AE,Tuttle RH,Poppers PJ

    更新日期:1989-01-01 00:00:00

  • Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia.

    abstract::Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 was a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

    更新日期:1991-11-01 00:00:00

  • Baroreflex control of heart rate during cardiac sympathectomy by epidural anesthesia in lightly anesthetized humans.

    abstract::To evaluate the effects of acute sympathetic denervation on the baroreflex control of heart rate, baroreflex sensitivities were compared in lightly anesthetized humans who had either cervical (N = 20) or lumbar epidural anesthesia (N = 18), or neither (N = 18). Levels of anesthesia during cervical block using 10 ml of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dohi S,Tsuchida H,Mayumi T

    更新日期:1983-09-01 00:00:00

  • Exhaled Propofol Concentrations Correlate With Plasma and Brain Tissue Concentrations in Rats.

    abstract:BACKGROUND:Propofol can be measured in exhaled gas. Exhaled and plasma propofol concentrations correlate well, but the relationship with tissue concentrations remains unknown. We thus evaluated the relationship between exhaled, plasma, and various tissue propofol concentrations. Because the drug acts in the brain, we f...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Müller-Wirtz LM,Maurer F,Brausch T,Kiefer D,Floss M,Doneit J,Volk T,Sessler DI,Fink T,Lehr T,Kreuer S

    更新日期:2021-01-01 00:00:00

  • Venodilation contributes to propofol-mediated hypotension in humans.

    abstract::The present investigation explored the possibility that the commonly observed hypotension that occurs during induction of anesthesia with propofol might be related to its ability to produce venodilation. Thirty-six ASA I and II patients who received no premedication were studied. The first 20 patients were divided int...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Muzi M,Berens RA,Kampine JP,Ebert TJ

    更新日期:1992-06-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model.

    abstract:BACKGROUND:Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dalesio NM,Hendrix CW,McMichael DH,Thompson CB,Lee CK,Pho H,Arias RS,Lynn RR,Galinkin J,Yaster M,Brown RH,Schwartz AR

    更新日期:2016-12-01 00:00:00

  • Case report: polyuria related to dexmedetomidine.

    abstract::Dexmedetomidine has become a popular sedative in the intensive care unit for patients undergoing mechanical ventilation because of its highly selective α-2 agonism, which exerts a combination of anesthetic, analgesic, and anxiolytic effects. Bradycardia and hypotension have been reported as the most common side effect...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Pratt A,Aboudara M,Lung L

    更新日期:2013-07-01 00:00:00

  • Capacity to give surgical consent does not imply capacity to give anesthesia consent: implications for anesthesiologists.

    abstract::There is precedent in medicine for recognizing and accepting intact decisional capacity and the subsequent ability to provide valid consent in one treatment domain, while simultaneously recognizing that the patient lacks decisional capacity in other domains. As such, obtaining consent for anesthesia for a surgical pro...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Marcucci C,Seagull FJ,Loreck D,Bourke DL,Sandson NB

    更新日期:2010-02-01 00:00:00

  • Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery.

    abstract:UNLABELLED:The effects of intravascular volume replacement regimens on tissue oxygen tension (ptiO(2)) are not definitely known. Forty-two consecutive patients scheduled for elective major abdominal surgery were prospectively randomized to receive either 6% hydroxyethyl starch (HES) (mean molecular weight 130 kd, degre...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版


    authors: Lang K,Boldt J,Suttner S,Haisch G

    更新日期:2001-08-01 00:00:00

  • Triple anesthetic combination: propofol-midazolam-alfentanil.

    abstract::The hypnotic effects of propofol, midazolam, alfentanil, and their binary and triple combinations, were studied in 130 unpremedicated patients in a randomized, double-blind fashion. The ability to open eyes on verbal command was used as an end-point. Dose-response curves for the three drugs given separately and in com...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vinik HR,Bradley EL Jr,Kissin I

    更新日期:1994-02-01 00:00:00

  • Changes in respiratory mechanics during cardiac surgery.

    abstract:UNLABELLED:We investigated the role of cardiopulmonary bypass (CPB) in compromised lung function associated with cardiac surgery. Low-frequency respiratory impedance (Zrs) was measured in patients undergoing cardiac surgery with (n = 30; CPB group) or without (n = 29; off-pump coronary artery bypass [OPCAB] group) CPB....

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Babik B,Asztalos T,Peták F,Deák ZI,Hantos Z

    更新日期:2003-05-01 00:00:00

  • The visual analog scale in the immediate postoperative period: intrasubject variability and correlation with a numeric scale.

    abstract:UNLABELLED:The visual analog scale (VAS) has been used to assess the efficacy of pain management regimens in patients with acute postoperative pain, but its usefulness has not been confirmed in postoperative pain studies. We studied 60 subjects in the immediate postoperative period. The specific data collected were: VA...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: DeLoach LJ,Higgins MS,Caplan AB,Stiff JL

    更新日期:1998-01-01 00:00:00

  • Factors associated with unanticipated day of surgery deaths in Department of Veterans Affairs hospitals.

    abstract:BACKGROUND:Patients of ASA physical status 1, 2, and 3 undergoing elective surgery do not have underlying conditions that are a constant threat to life, and hence should not be expected to be at significant risk for death on the day of surgery. METHODS:We analyzed 815,077 ASA physical status 1, 2, and 3 elective surge...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bishop MJ,Souders JE,Peterson CM,Henderson WG,Domino KB

    更新日期:2008-12-01 00:00:00

  • Hemodynamic response and change in organ blood volume during spinal anesthesia in elderly men with cardiac disease.

    abstract::Aging and disease may make the elderly patient with cardiac disease particularly susceptible to hypotension during spinal anesthesia. We studied 15 men, 59-80 y old, with histories of prior myocardial infarction (n = 9), congestive heart failure (n = 2), and/or stable myocardial ischemia (n = 11) given spinal anesthes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rooke GA,Freund PR,Jacobson AF

    更新日期:1997-07-01 00:00:00

  • Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits.

    abstract:BACKGROUND:IV lipid emulsion has demonstrated to be effective therapy for bupivacaine-induced cardiotoxicity. However, the role of epinephrine when coadministered with lipid emulsion in toxin-induced cardiac arrest is unclear. We postulated superior resuscitation outcome in the absence of epinephrine in a rabbit model ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Harvey M,Cave G,Prince G,Lahner D

    更新日期:2010-09-01 00:00:00

  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome.

    abstract:BACKGROUND:When temporary arterial occlusion of the parent artery is difficult for anatomical reasons, or when inadvertent aneurysmal rupture occurs during surgical dissection, adenosine administration can be used to produce flow arrest and brief, profound systemic hypotension that can facilitate intracranial aneurysm ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bebawy JF,Zeeni C,Sharma S,Kim ES,DeWood MS,Hemmer LB,Ramaiah VK,Bendok BR,Koht A,Gupta DK

    更新日期:2013-11-01 00:00:00