Abstract:
PURPOSE:To investigate the feasibility of obtaining reproducible apparent diffusion coefficient (ADC) maps of normal rat kidneys by using respiratory-triggered spin-echo diffusion-weighted magnetic resonance (MR) imaging, to investigate the sensitivity of ADC maps in the evaluation of renal blood flow, and to use this technique to monitor acute graft rejection in transplanted rat kidneys. MATERIALS AND METHODS:Spin-echo diffusion-weighted MR imaging measurements were performed in 20 normal rats and nine rats that had undergone transplantation (six rats had received allografts; three had received isografts) at 7 T. To evaluate the effect of alteration in blood flow and water transport function, angiotensin II was infused in six normal rats and a series of spin-echo diffusion-weighted MR images was obtained at five time points. Transplanted kidneys were monitored by obtaining spin-echo diffusion-weighted MR images and gradient-echo MR images every 2 hours for 8 hours on postoperative day 4. Statistical analysis was performed with repeated-measures multivariate analysis of variance and the paired t test. RESULTS:No significant differences in ADC values were observed between right and left kidneys in all three orthogonal directions; however, a small difference was observed between the cortex and medulla. ADC values in the cephalocaudal and mediolateral directions were higher than those in the anteroposterior direction (P <.01 for all). ADC values in the cortex and medulla decreased significantly (by >35%, P <.01) during angiotensin II-induced reduction in renal blood flow. No significant signal intensity change was observed between native and transplanted kidneys on gradient-echo MR images. Allografts exhibited decreased ADC values (P <.01) and isografts exhibited similar ADC values compared with native kidneys. CONCLUSION:These findings suggest that reproducible renal ADC maps can be obtained in rats by using spin-echo diffusion-weighted MR imaging at 7 T. Spin-echo diffusion-weighted MR imaging may have potential as a noninvasive tool for monitoring early graft rejection after kidney transplantation.
journal_name
Radiologyjournal_title
Radiologyauthors
Yang D,Ye Q,Williams DS,Hitchens TK,Ho Cdoi
10.1148/radiol.2313021587subject
Has Abstractpub_date
2004-06-01 00:00:00pages
702-9issue
3eissn
0033-8419issn
1527-1315pii
231/3/702journal_volume
231pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Traumatic spondylolisthesis of C-2, frequently referred to as the hangman's fracture, is typically regarded as a hyperextension injury with rare neurologic sequelae by virtue of decompression of the neural canal. The authors retrospectively evaluated their radiographic experience with this injury in 27 patients over a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.163.3.3575720
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:To use magnetic resonance (MR) imaging to examine the short-term (6 months) natural history of the lipid-rich necrotic core (LRNC) in carotid artery plaques by examining the placebo group of a multicenter clinical trial. MATERIALS AND METHODS:Study procedures and consent forms were approved by the institutiona...
journal_title:Radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1148/radiol.13121702
更新日期:2013-07-01 00:00:00
abstract::In two pathologically documented cases of renal cell carcinoma, the appearance of the tumors at magnetic resonance (MR) imaging was markedly hypointense relative to normal renal parenchyma on both T1- and T2-weighted spin-echo images. Pathologic examination of both tumors revealed diffuse iron scattered throughout the...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.2.2217790
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:To prospectively determine whether dynamic contrast material-enhanced (DCE) magnetic resonance (MR) quantitative parameters correlate with fibrosis and microvascular density (MVD) in malignant and benign solid pancreatic focal lesions and nontumoral pancreatic tissue. MATERIALS AND METHODS:The institutional re...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11103515
更新日期:2011-11-01 00:00:00
abstract::High-resolution computed tomography (CT) was correlated with pulmonary function tests in the evaluation of regional emphysema in 59 smokers. The lung was divided into upper (above the carina tracheae) and lower (below the carina tracheae) zones, and the degree of emphysema was graded with a subjective and an objective...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.183.2.1561350
更新日期:1992-05-01 00:00:00
abstract::The authors describe a coordinate measuring device developed to simplify manual acquisition of the digital information required for computerized three-dimensional treatment planning. This system has been used for two years and shown to be both fast and accurate. The time needed to digitize contour data is reduced to a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/115.1.187
更新日期:1975-04-01 00:00:00
abstract::Purpose To characterize intratumoral spatial heterogeneity at perfusion magnetic resonance (MR) imaging and investigate intratumoral heterogeneity as a predictor of recurrence-free survival (RFS) in breast cancer. Materials and Methods In this retrospective study, a discovery cohort (n = 60) and a multicenter validati...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2018172462
更新日期:2018-07-01 00:00:00
abstract::History A 43-year-old right-handed man presented with a history of progressive mild left-sided weakness and slowness of movements. Symptoms began 4 years earlier, and the patient noticed a progressive decline in his daily routine due to gait difficulties in the past year. There was no history of head trauma, surgery, ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017151717
更新日期:2017-05-01 00:00:00
abstract::Cystic hepatoblastomas share ultrasonographic characteristics with simple hepatic cysts; however, a distinction can be made by the demonstration of internal septations. The differentiation is important because cystic hepatoblastoma may have malignant potential. The ultrasonographic and scintigraphic findings in five c...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.138.1.6256810
更新日期:1981-01-01 00:00:00
abstract::Fifty-six cases of spondylolysis were encountered in 1500 lumbar spine reports reviewed. The frequency of detecting isthmus defects on anteroposterior (AP), lateral, 45-degree right and left oblique, 30-degree up-angled AP, and collimated lateral views was determined. The collimated lateral view showed the largest num...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.153.3.6494460
更新日期:1984-12-01 00:00:00
abstract::The effect of nuclear magnetic resonance (NMR) imaging on six representative cardiac pacemakers was studied. The results indicate that the threshold for initiating the asynchronous mode of a pacemaker is 17 gauss. Radiofrequency levels are present in an NMR unit and may confuse or possibly inhibit demand pacemakers, a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.1.6828720
更新日期:1983-04-01 00:00:00
abstract::A chart for organizing, teaching, and recording the magnetic resonance (MR) pulse sequences used for brain and cervical spine imaging is described. The chart helps document workable sequences and facilitates comparisons between different sequences. It has also been helpful in instructing residents and fellows how to a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.157.1.4034970
更新日期:1985-10-01 00:00:00
abstract::The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative we...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.142.1.7031760
更新日期:1982-01-01 00:00:00
abstract::A new method is presented for the removal of streaking artifact in computed tomography. The method uses a nearest-neighbor pattern recognition technique to redetermine ray sums that intersect the foreign object responsible for the streaking. When the method is applied to the removal of streaking artifact caused by lea...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.141.1.7291530
更新日期:1981-10-01 00:00:00
abstract:PURPOSE:To evaluate use of the transjugular intrahepatic portosystemic shunt (TIPS) as a nonsurgical approach for the management of Budd-Chiari syndrome (BCS). MATERIALS AND METHODS:Twelve patients with fulminant (n = 2), subacute (n = 5), or chronic (n = 5) BCS underwent TIPS placement. Hepatic venous obstruction was...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.197.3.7480760
更新日期:1995-12-01 00:00:00
abstract::Quantitative microstructural sonography differs from conventional sonography in several ways. The frequency as well as the amplitude of echoes is recorded and assessed using spectral analysis techniques. The effects of diffraction of the ultrasound beam are calibrated, as are the transfer characteristics of the system...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.155.2.2984720
更新日期:1985-05-01 00:00:00
abstract::Though the advent of computed tomography has improved the detection of posterior fossa lesions, there are times when it can not be used to differentiate between an intra- and extraaxial lesion, particularly when the mass is anteriorly located. Base view angiography can be used to make this distinction, accurately loca...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/124.1.157
更新日期:1977-07-01 00:00:00
abstract::Esophageal atresia may be associated with a long interval or gap between the upper and lower pouches. Despite a variety of procedures to elongate the esophagus, surgeons have been unable to achieve esophageal continuity in many patients. Three infants with esophageal atresia and long gaps recently underwent hydrostati...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.171.3.2717760
更新日期:1989-06-01 00:00:00
abstract:PURPOSE:To assess the reproducibility and accuracy of volumetric quantifications of articular cartilage in the knee determined with three-dimensional (3D) magnetic resonance (MR) imaging combined with pulsed saturation transfer subtraction (STS) or T1-weighted fat suppression (FS) imaging. MATERIALS AND METHODS:Eight ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.192.2.8029420
更新日期:1994-08-01 00:00:00
abstract:PURPOSE:To compare the reliability of acoustic radiation force impulse (ARFI) imaging and supersonic shear imaging (SSI) in measurement of liver stiffness. MATERIALS AND METHODS:This study was approved by the institutional review board, and written informed consent was obtained for all patients. Seventy-nine patients ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015141975
更新日期:2015-12-01 00:00:00
abstract::Gas cisternography was combined with edge-enhanced computed tomography (CT) in 6 patients and demonstrated the seventh and eighth cranial nerves thorugh both the cerebellopontine angle cistern and the internal auditory canal in the normal patients. The normal nerve outline was lost when a tumor was contained within th...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.136.3.7403560
更新日期:1980-09-01 00:00:00
abstract::Purpose To report the impact of changing from screen-film mammography to digital mammography (DM) in a large organized national screening program. Materials and Methods A retrospective analysis of prospectively collected annual screening data from 2009-2010 to 2015-2016 for the 80 facilities of the English National He...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018181426
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To investigate the feasibility of breast tissue characterization in terms of water, lipid, and protein contents with a spectral computed tomographic (CT) system based on a cadmium zinc telluride (CZT) photon-counting detector by using postmortem breasts. MATERIALS AND METHODS:Nineteen pairs of postmortem breas...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14132732
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To determine the ability of different types of gadolinium-based contrast agents (GBCAs) to stimulate fibroblast proliferation in monolayer cell culture. MATERIALS AND METHODS:The National Health Service West Glasgow Ethics Committee granted approval for this study. Fibroblasts established from healthy voluntee...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10091131
更新日期:2010-09-01 00:00:00
abstract::Depiction of small-bowel pathologic conditions was optimized with use of a negative luminal contrast agent, spectral fat suppression, and gadolinium enhancement in an excised gut phantom. The method was applied in nine patients in conjunction with standard enteroclysis examinations. Bulk susceptibility effects of oral...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.205.1.9315000
更新日期:1997-10-01 00:00:00
abstract::A 49-year-old premenopausal woman presented with acute onset of lower abdominal pain. Physical examination revealed her abdomen was distended and nontender. Her white blood cell count and serum markers for ovarian cancer were normal (alpha-fetoprotein level, 1.6 microg/L; Ca-125 level, 15 U/mL; beta-human chorionic go...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2441040790
更新日期:2007-07-01 00:00:00
abstract::We present the results of a study on the value of ultrasound in the detection of metastasis to the cervical lymph nodes in connection with cancer of the ear, nose, and throat. Comparison of clinical, ultrasound, and histological findings for 100 patients who underwent surgery revealed that clinical examination had a s...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.152.3.6463260
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:To compare survival of patients who undergo treatment in protocols versus survival of patients not in protocols. MATERIALS AND METHODS:Records of 81 adult patients with small-cell lung cancer who underwent chemotherapy and radiation therapy in 1987-1992 were reviewed retrospectively. Forty-one patients were in...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.197.3.7480770
更新日期:1995-12-01 00:00:00
abstract::Medical therapy is standard for intrahepatic amebic abscess and generally is effective. However, we have encountered a group of patients in whom percutaneous aspiration and drainage was indicated due to uncertainty of diagnosis or clinical deterioration of the patient. Twenty such patients underwent percutaneous drain...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.156.3.4023220
更新日期:1985-09-01 00:00:00
abstract::In obese individuals, a localized deposit of normal fat may simulate a mediastinal tumor on chest radiography. It is important to consider this possibility in the differential diagnosis to avoid needless surgery and facilitate continued observation when appropriate. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/119.1.74
更新日期:1976-04-01 00:00:00