Abstract:
:The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.
journal_name
Radiologyjournal_title
Radiologyauthors
Klintmalm GB,Klingensmith WC 3rd,Iwatsuki S,Schröter GP,Starzl TEdoi
10.1148/radiology.142.1.7031760subject
Has Abstractpub_date
1982-01-01 00:00:00pages
199-202issue
1eissn
0033-8419issn
1527-1315journal_volume
142pub_type
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