Acute pulmonary embolism: sensitivity and specificity of ventilation-perfusion scintigraphy in PIOPED II study.


PURPOSE:To use Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) II data to retrospectively determine sensitivity and specificity of ventilation-perfusion (V/Q) scintigraphic studies categorized as pulmonary embolism (PE) present or PE absent and the proportion of patients for whom these categories applied. MATERIALS AND METHODS:The PIOPED II study had institutional review board approval at all participating centers. Patient informed consent was obtained; the study was HIPAA compliant. Approval and consent included those for future retrospective research. Patients in the PIOPED II database of clinical and imaging results were included if they had diagnosis at computed tomographic (CT) angiography, Wells score, and diagnosis at V/Q scanning. V/Q scan central readings were recategorized as PE present (PIOPED II reading = high probability of PE), PE absent (PIOPED II reading = very low probability of PE or normal), or nondiagnostic (PIOPED II reading = low or intermediate probability of PE). A composite reference standard was used: the PIOPED II digital subtraction angiographic (DSA) result, or if there was no definitive DSA result, CT angiographic results that were concordant with the Wells score (ie, positive CT angiographic result and Wells score > 2 or negative CT angiographic result and Wells score < 6). Sensitivity and specificity of recategorized central readings were computed. RESULTS:With the exclusion of patients with intermediate or low probability, the sensitivity of a high probability (PE present) scan finding was 77.4% (95% confidence interval [CI]: 69.7%, 85.0%), while the specificity of very low probability or normal (PE absent) scan finding was 97.7% (95% CI: 96.4%, 98.9%). The percentage of patients with a PE present or PE absent scan finding was 73.5% (95% CI: 70.7%, 76.4%). CONCLUSION:In a population similar to that in PIOPED II, results of V/Q scintigraphy can be diagnostically definitive in a majority of patients; thus, it can be considered an appropriate pulmonary imaging procedure in patients for whom CT angiography may be disadvantageous.






Sostman HD,Stein PD,Gottschalk A,Matta F,Hull R,Goodman L




Has Abstract


2008-03-01 00:00:00














  • Suspected local recurrence after radical prostatectomy: endorectal coil MR imaging.

    abstract:PURPOSE:To evaluate endorectal coil magnetic resonance (MR) imaging in the depiction of local recurrence after radical prostatectomy. MATERIALS AND METHODS:Endorectal MR images were reviewed retrospectively in 82 patients who underwent prostatectomy. The interval between prostatectomy and MR imaging ranged between 0.5...


    pub_type: 杂志文章


    authors: Sella T,Schwartz LH,Swindle PW,Onyebuchi CN,Scardino PT,Scher HI,Hricak H

    更新日期:2004-05-01 00:00:00

  • Prospective versus retrospective ECG-gated 64-detector coronary CT angiography: assessment of image quality, stenosis, and radiation dose.

    abstract:PURPOSE:To show that prospective electrocardiographically (ECG)-triggered coronary computed tomographic (CT) angiography (hereafter, prospective CT angiography) is at least as effective as retrospective ECG-gated coronary CT angiography (hereafter, retrospective CT angiography). MATERIALS AND METHODS:Institutional rev...


    pub_type: 杂志文章,随机对照试验


    authors: Hirai N,Horiguchi J,Fujioka C,Kiguchi M,Yamamoto H,Matsuura N,Kitagawa T,Teragawa H,Kohno N,Ito K

    更新日期:2008-08-01 00:00:00

  • Bowel wall thickening in children: differentiation with US.

    abstract:PURPOSE:To determine whether vascular, ischemic, and inflammatory causes of bowel wall thickening in children can be differentiated at gray-scale and color Doppler ultrasonography (US). MATERIALS AND METHODS:Thirty-seven children with acute bowel disease underwent graded compression US. Findings of bowel wall thicknes...


    pub_type: 杂志文章


    authors: Siegel MJ,Friedland JA,Hildebolt CF

    更新日期:1997-06-01 00:00:00

  • Perianal Sepsis in Hematologic Malignancy: MR Imaging Appearances and Distinction from Cryptoglandular Infection in Immunocompetent Patients.

    abstract:PURPOSE:To use magnetic resonance (MR) imaging to document the appearance of perianal infection in patients with a hematologic malignancy (HM) compared with that in immunocompetent control patients. MATERIALS AND METHODS:After an ethical waiver was obtained, 38 patients with an HM were matched by age and sex to 38 con...


    pub_type: 杂志文章


    authors: Plumb AA,Halligan S,Bhatnagar G,Taylor SA

    更新日期:2015-07-01 00:00:00

  • Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation.

    abstract:PURPOSE:To prospectively evaluate airway wall thickness and lung attenuation at spirometrically gated thin-section computed tomography (CT) in patients with chronic obstructive pulmonary disease (COPD) and to correlate gated CT findings with pulmonary function test (PFT) results. MATERIALS AND METHODS:The ethical comm...


    pub_type: 杂志文章


    authors: Orlandi I,Moroni C,Camiciottoli G,Bartolucci M,Pistolesi M,Villari N,Mascalchi M

    更新日期:2005-02-01 00:00:00

  • Skeletal metastases from hepatoma: frequency, distribution, and radiographic features.

    abstract::Over the past 6 years, the authors evaluated 300 patients with hepatoma as part of phase 1 and 2 treatment protocol trials. Analysis of the available clinical data and radiographic studies revealed 22 patients (7.3%) with skeletal metastases demonstrated by radiography, computed tomography (CT), and/or nuclear scintig...


    pub_type: 杂志文章


    authors: Kuhlman JE,Fishman EK,Leichner PK,Magid D,Order SE,Siegelman SS

    更新日期:1986-07-01 00:00:00

  • Association of achalasia and pulmonary Mycobacterium fortuitum infection.

    abstract::A case of achalasia complicated by Mycobacterium fortuitum pulmonary infection and empyema is reported. This association has been documented in the medical literature. Possible mechanisms explaining this association are discussed. ...


    pub_type: 杂志文章


    authors: Aronchick JM,Miller WT,Epstein DM,Gefter WB

    更新日期:1986-07-01 00:00:00

  • The Meckel cave: computed tomographic study. Part I: Normal anatomy; Part II: Pathology.

    abstract::A formalin-fixed cadaver head with air filling the cisternal and ventricular spaces was scanned by high-resolution computed tomography (CT) in multiple planes (axial, coronal, and sagittal) through the Meckel cave. Correlation of the CT appearance of the Meckel cave was made with an anatomic dissection and whole-head ...


    pub_type: 杂志文章


    authors: Kapila A,Chakeres DW,Blanco E

    更新日期:1984-08-01 00:00:00

  • Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience.

    abstract:PURPOSE:To prospectively assess the oxygenation state of renal transplants and determine the feasibility of using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging to differentiate between acute tubular necrosis (ATN), acute rejection, and normal function. MATERIALS AND METHODS:This HIPAA-compliant s...


    pub_type: 杂志文章


    authors: Sadowski EA,Fain SB,Alford SK,Korosec FR,Fine J,Muehrer R,Djamali A,Hofmann RM,Becker BN,Grist TM

    更新日期:2005-09-01 00:00:00

  • Relative biological effectiveness of low- and high-LET radiotherapy beams for jejunal crypt cell survival at low doses per fraction.

    abstract::In order to determine the relative biological effectiveness (RBE) of various low- and high-LET radiotherapy beams of low coses, LAF1 mice were exposed to one dose and 10 equally fractionated doses of 60Co gamma rays, 137Cs gamma rays, 4-MeV x rays, 300-kVp x rays, helium ions in the plateau and Bragg-peak region, and ...


    pub_type: 杂志文章


    authors: Fu KK,Phillips TL,Heilbron DC,Ross G,Kane LJ

    更新日期:1979-07-01 00:00:00

  • Jejunal fold separation in adult celiac disease: relevance of enteroclysis.

    abstract::The number of folds in the proximal jejunum was measured retrospectively in 25 studies of patients with adult celiac disease and 75 control subjects. The average number of folds per inch of proximal jejunum in the group with celiac disease was 2.88 (none to five), as against 4.88 (three to seven) in the controls. The ...


    pub_type: 杂志文章


    authors: Herlinger H,Maglinte DD

    更新日期:1986-03-01 00:00:00

  • Ultrasonic visualization of an umbilical vein.

    abstract::A patent umbilical vein was demonstrated via ultrasound in a patient with portal hypertension. Ultrasonographic differential diagnosis of intra- and juxta-hepatic veins is given, with emphasis on real time ultrasonography. ...


    pub_type: 杂志文章


    authors: Weill F

    更新日期:1976-07-01 00:00:00

  • The soleal line: a cause of tibial pseudoperiostitis.

    abstract::An unusually prominent soleal line (a normal anatomic variant) may mimic periosteal reaction along the posterior margin of the proximal tibial shaft. This area of pseudoperiostitis is differentiated from hyperostoses arising from the anterior tibial tubercle and the interosseous membrane. It is always associated with ...


    pub_type: 杂志文章


    authors: Levine AH,Pais MJ,Berinson H,Amenta PS

    更新日期:1976-04-01 00:00:00

  • Bronchial anastomotic complications in lung transplant recipients: virtual bronchoscopy for noninvasive assessment.

    abstract:PURPOSE:To compare the accuracy of virtual bronchoscopy (VB) with that of axial computed tomography (CT) in the assessment of bronchial anastomotic complications in lung transplant recipients. MATERIALS AND METHODS:Twenty-seven bronchial anastomoses in 17 patients were evaluated with helical CT. Axial CT and VB images...


    pub_type: 杂志文章


    authors: McAdams HP,Palmer SM,Erasmus JJ,Patz EF,Connolly JE,Goodman PC,Delong DM,Tapson VF

    更新日期:1998-12-01 00:00:00

  • Breast cancer imaging with In-111 human IgM monoclonal antibodies: preliminary studies.

    abstract::Detection of specific tumor sites was studied with scintigraphy and radiolabeled human IgM monoclonal antibodies (MoAbs). Ten patients with metastatic breast cancer received an infusion of one of three indium-111-labeled anti-breast carcinoma MoAbs. The time of infusion ranged from 30 minutes to 2 hours. Three patient...


    pub_type: 杂志文章


    authors: Ryan KP,Dillman RO,DeNardo SJ,DeNardo GL,Beauregard J,Hagan PL,Amox DG,Clutter ML,Burnett KG,Rulot CM

    更新日期:1988-04-01 00:00:00

  • Carotid-cavernous fistula associated with intracranial fibromuscular dysplasia.

    abstract::Fibromuscular dysplasia (FMD) of the intracranial internal carotid and vertebro-basilar system is extremely rare. A case with diffuse intracranial involvement and an associated carotid-cavernous fistula is presented. The literature is reviewed and the pathogenesis of this complication of FMD is discussed. ...


    pub_type: 杂志文章


    authors: Zimmerman R,Leeds NE,Naidich TP

    更新日期:1977-03-01 00:00:00

  • The indeterminate CT pulmonary angiogram: imaging characteristics and patient clinical outcome.

    abstract:PURPOSE:To retrospectively review imaging characteristics of indeterminate computed tomographic (CT) pulmonary angiograms for pulmonary embolism (PE) and patient outcome. MATERIALS AND METHODS:Investigational review board approval was obtained, informed consent was waived, and the study was HIPAA compliant. Retrospect...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones SE,Wittram C

    更新日期:2005-10-01 00:00:00

  • Composition of mammographic phantom materials.

    abstract:PURPOSE:To determine the composition of a breast phantom that is most suitable for phototimer testing. MATERIALS AND METHODS:Kilovolt peak and milliampere second values were analyzed for phototimed exposures of phantoms containing 0%, 30%, 50%, 70%, and 100% simulated glandular material at thicknesses of 2, 4, 6, and ...


    pub_type: 杂志文章


    authors: Geise RA,Palchevsky A

    更新日期:1996-02-01 00:00:00

  • Angioplasty and stenting of completely occluded iliac arteries.

    abstract::Percutaneous angioplasty and placement of balloon-expandable intraluminal stents were performed in 12 iliac occlusions in 12 patients. Indications were limb salvage in seven and claudication in five. After successful stenting, ankle-brachial indexes improved by 0.15 or more in 11 of 12 patients (mean increase, 0.40), ...


    pub_type: 杂志文章


    authors: Rees CR,Palmaz JC,Garcia O,Roeren T,Richter GM,Gardiner G Jr,Schwarten D,Schatz RA,Root HD,Rogers W

    更新日期:1989-09-01 00:00:00

  • Left coronary arterial blood flow: noninvasive detection by Doppler US.

    abstract::Continuous wave (CW) and pulsed Doppler ultrasound studies with spectral analysis were used to detect the left coronary arterial blood flow in patients who were undergoing routine echocardiography. The pulmonary artery is a stable ultrasonic landmark from which detection of the blood flow can be effected. The left cor...


    pub_type: 杂志文章


    authors: Gramiak R,Holen J,Moss AJ,Gutierrez OH,Picone AL,Roe SA

    更新日期:1986-06-01 00:00:00

  • A new photon scattering method for bone mineral density measurements.

    abstract::A new technique for the determination of bone mineral density, based on the detection of both coherently and Compton scattered photons in a narrow beam geometry, is described. Initial results show that this method delivers an accuracy of less than 2% when varying quantities of materials surround the measuring site. ...


    pub_type: 杂志文章


    authors: Puumalainen P,Uimarihuhta A,Olkkonen H

    更新日期:1976-09-01 00:00:00

  • Thrombolytic therapy with recombinant human tissue-type plasminogen activator: a comparison of two doses.

    abstract::The efficacy and safety of two doses of recombinant human tissue-type plasminogen activator (rt-PA) were compared. Forty patients with peripheral arterial occlusions were treated with intraarterial rt-PA. Group A (n = 21) received 0.1 mg/kg/h, and group B (n = 19) received 0.05 mg/kg/h. Infusion durations varied from ...


    pub_type: 杂志文章


    authors: Risius B,Graor RA,Geisinger MA,Zelch MG,Lucas FV,Young JR

    更新日期:1987-08-01 00:00:00

  • Osteoid osteoma: CT-guided percutaneous excision confirmed with immediate follow-up scintigraphy in 16 outpatients.

    abstract:PURPOSE:To evaluate treatment of osteoid osteoma with computed tomography (CT)-guided percutaneous excision and immediate follow-up scintigraphy. MATERIALS AND METHODS:Sixteen consecutive adolescent and adult patients underwent CT-guided percutaneous excision of a nidus with 14-gauge biopsy cutting needles, with local...


    pub_type: 杂志文章


    authors: Roger B,Bellin MF,Wioland M,Grenier P

    更新日期:1996-10-01 00:00:00

  • Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures.

    abstract:PURPOSE:To evaluate the relationship among chest radiographs, oxygen supplementation requirement, and treatment response in severe acute respiratory syndrome (SARS). MATERIALS AND METHODS:Forty patients (20 women, 20 men; mean age, 42.90 years +/- 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with SARS w...


    pub_type: 杂志文章


    authors: Ooi CG,Khong PL,Ho JC,Lam B,Wong WM,Yiu WC,Wong PC,Wong CF,Lai KN,Tsang KW

    更新日期:2003-11-01 00:00:00

  • Mediastinal tumors: biopsy under US guidance.

    abstract::Percutaneous biopsies of mediastinal tumors were successfully performed under sonographic guidance in 14 of 21 patients. In 10 of 11 malignant lesions, malignancy was determined by means of cytologic and histologic examination of the specimens obtained. A histologic diagnosis was reached in seven patients with maligna...


    pub_type: 杂志文章


    authors: Wernecke K,Vassallo P,Peters PE,von Bassewitz DB

    更新日期:1989-08-01 00:00:00

  • Integrated stereotaxic imaging with CT, MR imaging, and digital subtraction angiography.

    abstract::A stereotaxic frame, compatible with digital subtraction angiography, computed tomography, and magnetic resonance imaging, is described along with a set of software programs that run in an independent imaging computer system, as well as in the computers associated with each modality. Plexiglas plates fastened to the s...


    pub_type: 杂志文章


    authors: Peters TM,Clark JA,Olivier A,Marchand EP,Mawko G,Dieumegarde M,Muresan LV,Ethier R

    更新日期:1986-12-01 00:00:00

  • Neonatal thyroid function: effect of a single exposure to iodinated contrast medium in utero.

    abstract:PURPOSE:To evaluate the effect of in utero exposure to a single dose of water-soluble intravenous iodinated contrast medium on thyroid function at birth. MATERIALS AND METHODS:This study was approved by the institutional review board, with waiver of consent, and was HIPAA compliant. Maternal and newborn records were r...


    pub_type: 杂志文章


    authors: Bourjeily G,Chalhoub M,Phornphutkul C,Alleyne TC,Woodfield CA,Chen KK

    更新日期:2010-09-01 00:00:00

  • Noninvasive Staging of Liver Fibrosis Using 5-Minute Delayed Dual-Energy CT: Comparison with US Elastography and Correlation with Histologic Findings.

    abstract::Background Normalized iodine concentration (NIC) (ratio of iodine concentration of liver to that of aorta) of liver at delayed dual-energy CT (DECT) may reflect the amount of fibrosis based on the extent of iodine uptake. Purpose To stage liver fibrosis by using 5-minute delayed DECT and compare findings with those of...


    pub_type: 杂志文章


    authors: Marri UK,Das P,Shalimar,Kalaivani M,Srivastava DN,Madhusudhan KS

    更新日期:2021-01-05 00:00:00

  • Pleural telangiectasia and absence of a pulmonary artery.

    abstract::The radiological features of absence of a pulmonary artery are often characteristic enough to allow a diagnosis based on the plain radiograph. They include a small hemithorax, ipsilateral displacement of the mediastinum, absence of the corresponding pulmonary artery, and reticular parenchymal densities, generally attr...


    pub_type: 杂志文章


    authors: Kleinman PK

    更新日期:1979-08-01 00:00:00

  • Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results.

    abstract:PURPOSE:To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases. MATERIALS AND METHODS:In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot se...


    pub_type: 临床试验,杂志文章


    authors: Vogl TJ,Müller PK,Hammerstingl R,Weinhold N,Mack MG,Philipp C,Deimling M,Beuthan J,Pegios W,Riess H

    更新日期:1995-07-01 00:00:00