Science to practice: will contrast agents for molecular imaging of angiogenesis help overcome the limitations of functional vascular imaging?

Abstract:

:Schmieder and colleagues introduced a new molecular magnetic resonance (MR) probe with a promising lipophilic gadolinium chelate complex that provides high relaxivity. Results of in vivo experiments clearly demonstrate the excellence of the probe for longitudinally monitoring α(v)β(3) integrin expression in tumors. In addition, the authors have developed a robust nonrelaxometric analysis method with which to quantify the spatial distribution of molecular MR probes. In combination with a molecular probe targeting angiogenesis, this approach may be superior to functional vascular assessments. It has the potential to enable better detection of angiogenic regions in heterogeneous tumors and to improve the monitoring and individualization of antiangiogenic treatments.

journal_name

Radiology

journal_title

Radiology

authors

Kiessling F

doi

10.1148/radiol.13131094

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

309-11

issue

2

eissn

0033-8419

issn

1527-1315

pii

268/2/309

journal_volume

268

pub_type

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