Abstract：
AIM:To study renal functional reserve and 24-h beta 2-microglobulinuria (B2-MGU) in patients with different stages of essential hypertension (EH) and to evaluate acceptability of these parameters as early markers of preclinical renal impairment in EH. METHODS:We examined 150 patients (mean age 42.1 +/- 3.4 years) with EH without overt clinical manifestations of hypertensive nephropathy. Renal functional reserve (RFR) was determined with the use of acute oral protein loading and was defined as an increase in endogenic creatinine clearance in percent. B2-MGU was evaluated by radioimmunoassay (RIO-BETA-2-MICRO kit). Radioimmunoassay detection of microalbuminuria (MAU) was performed with the use of the standard kit Albumin-RIA. RESULTS:RFR appeared to be significantly lower in patients with EH compared to the control group, and its level significantly decreased with aggravation of EH. Both B2-MGU and MAU were significantly higher in patients with EH and significantly increased with aggravation of EH. CONCLUSION:We suggest that, apart from MAU, RFR abnormalities and excessive B2-MGU should be used as markers of preclinical renal impairment in EH.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Grinshteĭn IuI,Shabalin VVsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
40-3issue
4eissn
0040-3660issn
2309-5342journal_volume
76pub_type
杂志文章abstract：:The trends in atherosclerosis presentation were followed up pathomorphologically in a two-stage epidemiological survey performed in 9 cities of CIC and Baltic states at 25-year interval. The investigations were conducted in accordance with WHO program. Stage 1 (1963-1968) covered 6121 cases, stage 2 (1985-1989) includ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：AIM:To clarify the effect of cyclosporin A (CSA) on the apoptosis and proliferative activity of bone marrow cells in patients with aplastic syndromes by trepanobiopsy evidence. MATERIALS AND METHODS:The TUNEL immunohistochemical assay was used to study apoptosis of bone marrow cells in the histological specimens from ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:The paper provides a review of the literature on a relevant non-drug prevention problem, namely the negative effect of trans isomers of unsaturated fatty acids (trans-UFA) on the risk of circulatory system diseases (CSD) and other chronic noncommunicable diseases. It gives data on the specific features of the structur...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:Altogether 216 patients with grave infection-dependent (49.5%) and autoimmune (50.5%) bronchial asthma received 311 courses of immunosuppressant therapy, with follow up periods up to 8 years. According to the clinico-immunologic data the patients were distributed into 4 groups. The basic drugs were (1) azathioprin, (2...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:To investigate sex- and age-specific features of radiographic abnormalities in rheumatoid arthritis (RA) patients, radiographic signs in hands and feet were assessed using Steinbroker criteria. A score system from 0 to 3 was also introduced to evaluate every radiographic feature: osteoporosis, cysts, joint space narro...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:One of the mechanisms responsible for occupational dermatoses of constructors in contact with Cr-containing substances is supposed to be antibodies production as a result of Cr ion migration in the blood. The authors' measurements led them to the conclusions that no significant rise in blood Cr content occurs with an ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:To compare efficacy and safety of atenolol, methoprolol and bisoprolol, as the most usable beta-blockers, in patients with isolated systolic arterial hypertension (ISAH) and concomitant diabetes mellitus (DM) and/or chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS:Forty tow patients with ISAH and...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-01-01 00:00:00
abstract：AIM:To ascertain criteria of aggressive course of juvenile rheumatoid arthritis (JRA) during 6-12 months since the disease onset, to measure the rate of destruction progression, to formulate indications for conduction of early immunosuppressive therapy. MATERIALS AND METHODS:The study included 30 patients (21 girls an...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：AIM:To elucidate the effects of combined therapy with glucocorticosteroids (GCS) and recombinant human interferon alpha or gamma (IFN) on proliferative responses of T-lymphocytes activated by various surface molecules (CD3 and CD2) in patients with SLE. MATERIALS AND METHODS:A 3-month trial entered 3 groups 15 patient...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:A study was made of immunologic cell markers in 32 patients with acute myeloid leukemia by indirect immunofluorescence with the aid of xenogeneic antisera and monoclonal antibodies obtained by the authors. Ia-like antigen demonstrated by monoclonal antisera IKO-I expressed in myeloblastic leukemia with maturation in m...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:In the Russian Federation, the increase in all-cause and cardiovascular disease mortality began in the 1960s and lasted almost continuously until 2003. In our country, the characteristics of mortality are its substantially higher rates among men and a large regional variability, which is associated with economic, clim...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.17116/terarkh20178915-13
更新日期：2017-01-01 00:00:00
abstract：:The paper is concerned with the results of clinical assessment of a new peptide drug dalargin in therapy of duodenal peptic ulcer. Assessment of the efficacy of dalargin was compared to that of tagamet and placebo using double "blind" control. A total of 180 males with exacerbation of duodenal ulcer were examined, of ...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The paper discusses issues related to the role of basic studies in the development of practical medicine and to the integration of basic science and medical treatment. ...
journal_title：Terapevticheskii arkhiv
pub_type： 社论
doi：
更新日期：2012-01-01 00:00:00
abstract：:The paper shows more than 40 years' experience with ursodeoxycholic acid (UDCA) used as a drug; during this period it has demonstrated its rather high clinical efficacy. Due to the range of its inherent pleiotropic (choleretic, cytoprotective, immunomodulatory, antiapoptotic, hypocholesterolemic, and litholytic) prope...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.17116/terarkh201587484-90
更新日期：2015-01-01 00:00:00
abstract：AIM:To compare clinical, cost-effect efficacies and safety of simvastatin Zokor and generic Vasilip in correction of dislipoproteinemia in patients with ischemic heart disease. MATERIAL AND METHODS:The original statin Zokor and generic statin Vasilip were given for 8 weeks in a dose 20 mg/day. RESULTS:Vasilip and Zok...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Enterosorbents were tried clinically in 90 patients with chronic renal failure and in vitro (immersion into gastric juice, enteral and colon content). Advantages of granulated carbone sorbents over polyphepan, lignin derivative, were evident. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The article provides an overview of current views on the involvement of the liver, gallbladder, and pancreas in patients with overweight and obesity. It considers the general issues of the pathogenesis of these conditions, their clinical features and diagnostic methods. :В статье приводится обзор современных взглядов...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.17116/terarkh2017891128-133
更新日期：2017-01-01 00:00:00
abstract：:As many as 30 patients suffering from systemic lupus erythematosus (SLE) with the clinical signs of central nervous system derangement were examined. The mean age of the patients was 31.1 years. Using EIA, antibodies against cardiolipin (a-CL) were detected in 21 patients (70%). A-CL were revealed in all the patients ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The paper is concerned with the results and analysis of transesophageal electrocardiostimulation in 383 patients before and in hospital over 6 years for urgent therapy of brady- and tachyarrhythmias. The method was assessed using a simple, recoverable and effective first aid element in combined resuscitation measures,...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Diabetes mellitus is a key cause of chronic kidney disease (CKD) in developed contries. Disorders of glucose metabolism regulation in CKD are explained by insulin resistance, decreased insulin clearance, weak hormonal response to hypoglycemia. These disturbances appear in inhibition of glomerular filtration rate under...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The paper is concerned with a case of Brill-Symmers' disease started with the thrombocytopenic syndrome relating to hypersplenism. After splenectomy the first benign stage of disease without eradication therapy lasted over 10 years. Signs of immunological incompetence (signs of secondary infection) and recurring immun...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：AIM:To assess efficacy of cyclopheron (Polysan production) as opisthorchiasis pretreatment in patients with chronic viral hepatitis C (CHC). MATERIAL AND METHODS:Fifteen CHC patients received cyclopheron by 6 month scheme before dehelminthization. The effect was evaluated by dynamics of clinical symptoms, results of f...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：AIM:To characterize hypertensive patients, residents of Moscow, treated at Moscow Municipal Cardiological Center (MMCC) in 1999. MATERIAL AND METHODS:A total of 1056 case histories of patients with the diagnosis of arterial hypertension or essential hypertension, directed to MMCC in 1999, were analyzed. The files were...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：AIM:To study nebivolol efficacy in pregnant and puerperal women with hypertension. MATERIAL AND METHODS:Monitoring of endothelial function, central and peripheral hemodynamics (HD), myocardial function, intrarenal circulation and microalbuminuria (MAU) was performed in 90 pregnant (67 hypertensive and 23 normotensive)...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Altogether 76 patients with terminal chronic renal failure (CRF) were examined for the intensity of endogenous intoxication and its action mechanism in blood serum. To determine the degree of intoxication, use was made of neuromuscular preparations of Rana temporaria. In order to study the action mechanism of the toxi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The paper provides current views on the structure and functional activity of bacterial toxins, clinical use of bacterial lipopolysaccharides and their derivatives as immunostimulators, review investigations on the introduction of the botulinic toxin A in ophthalmological and neurological practice, on production of imm...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Application of a modern method of introscopy--electroimpedance tomography (EIT) for diagnosis of different types of lung diseases is described. The EIT system including measurement and collecting data devices, 16-electrodes array and IBM PC 486 computer was used. The results of analysis of electrotomograms have demons...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：AIM:To characterize a superficial phenotype and to make a cytogenetic analysis of bone marrow (BM) mesenchymal stromal cells (MSC) from donors. MATERIALS AND METHODS:The study analyzed BM samples from 11 healthy donors. The phenotype of obtained MSC was analyzed using cytofluorometry. Chromosomal analysis was carried ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：AIM:To investigate effects of trimetazidine and perindopril on myocardial function and metabolism in patients with cardiac failure after myocardial infarction. MATERIAL AND METHODS:A comparative study was mode of the effects of 6-month therapy with perindopril, trimetazidine alone and in combination on clinical sympto...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-01-01 00:00:00
abstract：:Neurological complications were examined in 30 patients with multiple myeloma. The neurological syndromes which play the key role in the clinical picture of the disease were distinguished. The pathogenetic mechanisms of the development of the individual symptoms and the methods for their treatment are discussed. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
