[Interferon therapy effects on activation of T-lymphocytes in patients with systemic lupus erythematosus].

Abstract:

AIM:To elucidate the effects of combined therapy with glucocorticosteroids (GCS) and recombinant human interferon alpha or gamma (IFN) on proliferative responses of T-lymphocytes activated by various surface molecules (CD3 and CD2) in patients with SLE. MATERIALS AND METHODS:A 3-month trial entered 3 groups 15 patients each with verified SLE by APA criteria (1982). Patients of group 1, 2 and 3 received IFN-alpha (realdiron, Biofa, Lithuania) in a single dose 3 million IU i.m., IFN-gamma (inflagen, Biofa, Lithuania) in a single dose 3 million IU i.m. and cyclophosphamide in a dose 200 mg i.m. once a week, respectively. T-lymphocyte proliferative response was assessed to stimuli of two types: CD3-dependent (classic activation) and CD2-dependent (alternative activation). The analysis was made by inclusion of 3H-thymidine after 72-hour incubation of peripheral blood mononuclear cells with various stimuli. The response was assessed before the treatment, on the treatment day 20 and after the treatment. The blood from 27 donors was also examined. Flow cytometry estimated the percentage of the cells expressing molecules CD3, CD4, CD8. RESULTS:The effect is found of alpha and gamma INF on functional capacity of T-lymphocytes and on the number of cells expressing surface molecules CD3 and CD4. Realdiron produced two-phase reaction to a proliferative response to mitogenic stimuli by CD3-dependent activation pathway: the initial rise then lowering. CD2-dependent way of T-cell activation is associated with weakening of responses to all combinations of stimuli with participation of autologous red cells. This group of patients to the end of the therapy exhibited a significant decrease in the number of cells expressing CD3 and CD4 (p < 0.05 and p < 0.001, respectively). Inflagen enhanced CD3-dependent activation of T cells and normalized the response to all types of the alternative stimuli. This group demonstrated an increase in the number of cells expressing CD3 and CD4 (p < 0.01 and p < 0.05, respectively). The changes in the number of CD8+ cells in both the groups were statistically insignificant. The controls had T-cell responses reduced by both activation pathways. CONCLUSION:Preparations of both alpha and gamma interferon have a multidirectional influence on functional potential and phenotype of T-lymphocytes of SLE patients.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Stanislav ML,Balabanova RM,Nikonova MF,Litvina MM,Iarilin AA

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

44-9

issue

5

eissn

0040-3660

issn

2309-5342

journal_volume

72

pub_type

临床试验,杂志文章
  • [Features of the epidemiologic characteristics of ischemic heart disease among scientific research workers].

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    doi:

    authors: Timofeeva TN,Zhukovskiĭ GS,Khaltaev NG,Kazanskaia AI,Bulin VA

    更新日期:1987-01-01 00:00:00

  • [Science and clinical practice].

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    journal_title:Terapevticheskii arkhiv

    pub_type: 社论

    doi:

    authors: Chazov EI

    更新日期:2012-01-01 00:00:00

  • [Morphofunctional status of the gastric mucosa in acalculous diseases of the biliary tract].

    abstract:AIM:To study morphofunctional peculiarities of gastric mucosa in native and migrant rural population of North Siberia. MATERIAL AND METHODS:A comprehensive clinicomorphological examination including physical examination, ultrasonic scanning, cholecystography, duodenal intubation, intragastric pH-metry, esophagogastrod...

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    doi:

    authors: Tsukanov VV,Barkalov SV,Tonkikh IuL

    更新日期:2003-01-01 00:00:00

  • [Immunomorphological evaluation of intestinal function in periodic disease patients].

    abstract::Based on clinico-endoscopic, x-ray, immunological and immunohistochemical studies the authors demonstrate the role of disorders in the components of humoral and cellular immunity in the development of intestinal inflammation and amyloidosis in patients with periodical disease. Circulatory disorders, congestive hyperem...

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    pub_type: 杂志文章

    doi:

    authors: Mamikonian RS,Arutiunian VM,Eganian GA

    更新日期:1984-01-01 00:00:00

  • [A trial of the long-term use of Sedacorone (amiodarone) under polyclinic conditions for the prevention of paroxysms of atrial fibrillation].

    abstract::Sedacorone (amiodarone) was given to 70 outpatients with coronary heart disease for 1.5-2 years to prevent paroxysms of cardiac arrhythmia after recovery of sinus rhythm. Sedacorone was administered initially in the dose 600 mg/day for 10-12 days, then the dose lowering was adjusted to the tolerance, heart rate and EC...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bart BIa,Mamtsev BN,Larin VG,Smirnova OL

    更新日期:1997-01-01 00:00:00

  • [Right ventricular dilatation in patients with coronary heart disease without myocardial infarction: According to the data of the Coronary Angiography Surgery Registry].

    abstract:AIM:To identify factors associated with right ventricular (RV) dilatation in patients with coronary heart disease (CHD) without prior myocardial infarction (Ml). SUBJECTS AND METHODS:Out of 16 839 patents from the Coronary Angiography Surgery Registry, the investigators selected patients with >75% stenosis in at least...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201587934-38

    authors: Kuznetsov VA,Yaroslavskaya EI,Pushkarev GS,Krinochkin DV,Bessonov IS,Gorbatenko EA

    更新日期:2015-01-01 00:00:00

  • [Croup in toxic forms of diphtheria in adults].

    abstract::Toxic patterns of diphtheria of the fauces in adults are characterized by laryngeal lesions which considerably deteriorate the disease prognosis. The clinical manifestations of diphtheric croup may be unpronounced in such cases and be masked by other severe disease symptoms. If patients with toxic diphtheria develop c...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Pokrovskiĭ VI,Ostrovskiĭ NN,Astaf'eva NV,Filimonova NV

    更新日期:1985-01-01 00:00:00

  • [The synthetic peptide preparation dalargin in the treatment of peptic ulcer].

    abstract::The paper is concerned with the results of clinical assessment of a new peptide drug dalargin in therapy of duodenal peptic ulcer. Assessment of the efficacy of dalargin was compared to that of tagamet and placebo using double "blind" control. A total of 180 males with exacerbation of duodenal ulcer were examined, of ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Smagin VG,Vinogradov VA,Bulgakov SA,Propisnova EP,Titov MI

    更新日期:1987-01-01 00:00:00

  • [Sandostatin in the treatment of diarrhea of different origins].

    abstract::Antidiarrheal action of sandostatin (octreotide) was studied in dumping syndrome, diabetic enteropathy, short-bowel syndrome, Crohn's disease and ulcerative colitis. Sandostatin proved effective in diarrhea of secretory, motor and osmotic origin. Dumping syndrome, diabetic enteropathy, Crohn's disease and short-bowel ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Belousova EA,Zlatkina AR,Mishurovskaia TS,Bezzubik KV

    更新日期:1995-01-01 00:00:00

  • [Errors in the diagnosis of tuberculosis of the respiratory organs in a pulmonological hospital and the possibilities of their prevention].

    abstract::Respiratory tuberculosis in a pulmonary inpatient setting is not rare but, as a rule, is not diagnosed in time. Tuberculosis-directed alertness, especially in patients with an atypical lingering course of disease, the absence of the effect of nonspecific antibacterial therapy, risk factors (immunodeficiency state, dia...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Daniliak IG,Rostislavina OA,Solomakhina NI

    更新日期:1988-01-01 00:00:00

  • [Postinfarction remodeling of the left atrium and left ventricle: effects of long-term treatment with beta adrenergic blockers and angiotensin converting enzyme inhibitors].

    abstract:AIM:To study changes in left atrial volume, geometry and function in myocardial infarction (MI) patients treated with beta-adrenoblocker and ACE inhibitor. MATERIAL AND METHODS:65 patients with Q-wave myocardial infarction (MI) were followed up for 6 months. Regular check-ups included clinical examination, ECG, echo-C...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Mazur NA,Vikent'ev VV

    更新日期:2001-01-01 00:00:00

  • [The cardiology dispensary, its structure and functions (the work experience of the dispensary in Tomsk)].

    abstract::The first experience of the activities of a cardiological dispensary was summed up. The authors proposed its structure developed in accordance with the goals set before dispensaries. The appropriateness of some of them was discussed. The main types of the activities of a dispensary were discussed. ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Potapov AI,Karpov RS,Plotnikova ND,Smirnova TA

    更新日期:1987-01-01 00:00:00

  • [Enteral tube feeding in adult patients with cystic fibrosis and respiratory failure].

    abstract:AIM:To evaluate the efficiency of nocturnal hyperalimentation in adult patients with cystic fibrosis (CF) and respiratory failure. SUBJECTS AND METHODS:The investigation enrolled 17 patients older than 18 years (mean age, 25.6±4.2 years) diagnosed with very severe CF (forced expiratory volume in one second (FEV1), < 3...

    journal_title:Terapevticheskii arkhiv

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  • [Clinical considerations in the treatment of atrial fibrillation (in thyrotoxicosis patients)].

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    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kedrov AA,Somova LV

    更新日期:1984-01-01 00:00:00

  • [The value of bone mineral density assessment by dual-energy x-ray absorptiometry for prediction of cardiovascular mortality in patients treated with hemodialysis].

    abstract:AIM:Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. MATERIALS AND METHODS:A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men 265, women 251, ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/00403660.2020.06.000277

    authors: Mazurenko SO,Nakatis YA,Enkin AA,Staroselsky KG,Vasiliev AN,Mazurenko OG,Soin PV,Ermolaeva LG,Ivanov IG

    更新日期:2020-07-09 00:00:00

  • [Humoral and cellular indices of nonspecific resistance in viral hepatitis A and ascorbic acid].

    abstract::A total of 260 patients aged 15 to 57 years with virus hepatitis A were examined over time for some indicators of humoral and cellular immunity (serum IgA, IgM, IgG, the phagocytic number and indicator of the completeness of neutrophil phagocytosis, cytochemical content of ribonucleic and deoxyribonucleic acids in blo...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Vasil'ev VS,Komar VI,Kisel' NI

    更新日期:1989-01-01 00:00:00

  • [Clinico-statistical analysis of chronic cardiac failure].

    abstract:AIM:To analyse epidemiologically chronic heart failure (CHF) according to 1996 records for patients admitted to therapeutic and cardiological departments of Moscow city hospital N 64. MATERIALS AND METHODS:An individual sheet has been developed for computer. The statistical processing has been conducted according to A...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Tereshchenko SN,Demidova IV,Levchuk NN,Kobalava ZhD

    更新日期:1999-01-01 00:00:00

  • [Prevalence of bronchial asthma and allergic rhinitis in the adult population of St. Petersburg].

    abstract:AIM:To evaluate prevalence of bronchial asthma (BA) and allergic rhinitis (AR) among adult population of St-Petersburg. MATERIAL AND METHODS:Responders to ECRHS and B. Sibbald & E. Rink questionnaires who gave at least one positive answer were examined clinically, functionally and allergologically. A total of 3634 res...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Fedoseev GB,Emel'ianov AV,Sergeeva GR,Ivanova NI,Zibrina TM,Maksimenko IN,Tsukanova IV

    更新日期:2003-01-01 00:00:00

  • [State of lipid peroxidation, blood antioxidant defense in patients with myocardial infarction aggravated by circulatory insufficiency].

    abstract:AIM:To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure. MATERIAL AND METHODS:Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Tarasov NI,Tepliakov AT,Malakhovich EV,Stepacheva TA,Fedosova NN,Kaliuzhin VV,Pushnikova EIu

    更新日期:2002-01-01 00:00:00

  • Minimal hepatic encephalopathy: current clinical and pathogenetic aspects.

    abstract::The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:10.26442/terarkh201890289-93

    authors: Damulin IV

    更新日期:2018-02-15 00:00:00

  • [The prevalence of bacterial overgrowth syndrome and its associated factors in patients with inflammatory bowel diseases (according to the data of the Novosibirsk registry)].

    abstract:AIM:To assess the prevalence of bacterial overgrowth syndrome (BOS) and its risk factors in patients with inflammatory bowel diseases (IBD). SUBJECTS AND METHODS:The patients from the Novosibirsk IBD registry, who had undergone a hydrogen breath test (HBT) using a Gastro+ device, were examined. RESULTS:In 93 IBD pati...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201789215-19

    authors: Kulygina YA,Osipenko MF,Skalinskaya MI,Pal'chunova KD

    更新日期:2017-01-01 00:00:00

  • [Role of electron-beam tomography in diagnosing patency of aortocoronary and mammary-coronary shunts (from data from a 3-year study)].

    abstract:AIM:To assess informative value of electron-beam tomography (EBT) and to compare dynamics of occlusive defects of autovenous and autoarterial shunts. MATERIAL AND METHODS:36 patients with coronary heart disease entered the study. All the patients have undergone coronary artery bypass operation and/or mammarocoronary b...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Veselova TN,Sinitsyn VE,Fedotenkov IS,Vasil'ev VP,Shiriaev AA,Ternovoĭ SK

    更新日期:2003-01-01 00:00:00

  • [The new basic agent prospidin in the therapy of rheumatoid arthritis. An evaluation of the clinical effectiveness and the mechanism of action of prospidin].

    abstract::A therapeutic effect of prospidine, a Soviet antitumor drug, was studied on the basis of clinicoimmunological correlations in 74 patients with proved rheumatoid arthritis (RA) who were resistant to well known basic drugs. It was administered parenterally and intraarticularly according to the methods developed by the a...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Benenson EV,Nemtsov BF,Krasnov SL

    更新日期:1986-01-01 00:00:00

  • Hepatic involvement in sarcoidosis.

    abstract::Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Liver is frequently involved in the pathological process. Wide range of clinical manifestations can be seen: from asymptomatic lesion with normal liver function tests to cirrhosis with portal hypertension. Biopsy plays the key role in diagnosis of...

    journal_title:Terapevticheskii arkhiv

    pub_type: 社论

    doi:10.26442/00403660.2019.04.000179

    authors: Fomin VV,Brovko MY,Kalashnikov MV,Sholomova VI,Rozina TP,Akulkina LA,Pershina AE,Yanakayeva AS,Nekrasova TP

    更新日期:2019-05-15 00:00:00

  • [The clinical and hemodynamic efficacy of telmisartan and enalapril in the treatment of arterial hypertension in patients with type 2 diabetes mellitus].

    abstract:AIM:To study the effects of enalapril and telmisartan on hemodynamic parameters and diastolic function (DF) of the left ventricle (LV) in patients with type 2 diabetes mellitus (DM) concurrent with arterial hypertension (AH). SUBJECTS AND METHODS:The study included 64 patients (mean age 54.3 +/- 5.2 years) with type 2...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Tatarchenko IP,Pozdniakova NV,Mordovina AG,Morozova OI,Zaĭtseva AV

    更新日期:2009-01-01 00:00:00

  • [Regulatory R proteins and lipid peroxidation in rheumatoid arthritis].

    abstract::Levels of R proteins (RP) and activity of lipid peroxidation (LPO) were measured in 209 patients with RA. It was noted that RP levels and LPO activity correlated with the activity of inflammation. A rapid RA progression was characterized by higher RP levels and LPO activity, while polyarthritis by more intensive RP me...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kochetova EV,Ignat'ev VK

    更新日期:1996-01-01 00:00:00

  • [Effects of endotheline and nitric oxide on vascular tonicity in patients with chronic cardiac failure].

    abstract:AIM:To examine effects of endotheline-1 (ET-1) and nitric oxide (NO) on endothelium-dependent mechanisms of vascular tonicity regulation in patients with chronic cardiac failure (CCF) of FC I-IV (NYHA). MATERIAL AND METHODS:Vascular reactions of 94 patients with CCF of FC I-IV were examined according to D.S. Celermaje...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Denisov EN,Kots IaI,Bakhtiiarov RZ,Gumanova NG

    更新日期:2007-01-01 00:00:00

  • The clinical significance of insulin resistance in non-diabetic patients with early forms of non-alcoholic fatty liver disease.

    abstract:AIM:To assess the presence of insulin resistance (IR) in non-diabetic patients with early forms of non-alcoholic fatty liver disease (NAFLD) - liver steatosis (LS) and steatohepatitis (SH) of mild activity and the influence of IR on the clinical course of these diseases. MATERIALS AND METHODS:134 patients with NAFLD w...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

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    authors: Shipovskaya AA,Dudanova OP,Kurbatova IV

    更新日期:2018-08-27 00:00:00

  • [The clinical significance of the liver glutathione system in chronic lesions].

    abstract::It is shown that chronic hepatobiliary pathology is associated with a fall in spontaneous metabolite conjugation related to reduced concentration of hepatic glutathione. There was also enhanced activity of glutathione-dependent enzymes. This indicates progress of compensatory processes associated with mobilization of ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Loginov AS,Matiushin BN,Tkachev VD

    更新日期:1997-01-01 00:00:00

  • [A trial of using allogeneic bone marrow transplantation in children with different hematologic neoplastic diseases].

    abstract:AIM:To define optimal time for transplantation of bone marrow (TBM) in children with hematological malignancies. MATERIALS AND METHODS:20 allogenic TBMs were performed in children with acute myeloblastic leukemia (6 patients, 2 of them in recurrence), acute lymphoblastic leukemia (7 patients, 4 of them in recurrence),...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Zubarovskaia LS,Sitskaia KO,Marinets OV,Fregatova LM,Belogurova MB,Trofimova SA,Chukhlovin AB,Afanas'ev BV

    更新日期:1998-01-01 00:00:00