Abstract:
BACKGROUND:An immunohistochemical study was conducted to compare distributions of mast cell subpopulations in normal human gingiva and in gingival overgrowth induced by nifedipine and immunosuppressive medication. METHODS:Gingival samples were collected from 12 triple-medicated organ transplant recipients (immunosuppression group), 11 triple-medicated organ transplant recipients taking nifedipine (immunosuppression plus nifedipine group), 11 nifedipine-medicated cardiac outpatients (nifedipine group), and 20 generally healthy individuals (control group). Cryostat sections were stained with mAbs for tryptase and chymase, and an avidin-biotin enzyme complex method was used to detect tryptase-positive mast cells (MC(T)), tryptase- and chymase-positive mast cells (MC(TC)), and chymase-positive mast cells (MC(C)). Total numbers of labeled cells were determined in connective tissue beneath the sulcular epithelium, connective tissue beneath the oral epithelium, and middle connective tissue. Statistical analyses were conducted using the Kruskal-Wallis test, the Mann-Whitney U-test, and Pearson's correlation test. RESULTS:In the three counting zones combined, numbers of MC(TC) cells and MC(C) cells were lower (P = 0.001 and P = 0.048, respectively) in the immunosuppression group than in the control group. The difference in numbers of MC(TC) cells was most marked in the middle connective tissue. Nifedipine medication had no effect on numbers of the mast cell subclasses. CONCLUSIONS:Immunosuppressive medication without concomitant nifedipine decreases the numbers of MC(TC) and MC(C) in overgrown gingiva. Chymase-positive mast cells may play a role in formation of gingival overgrowth, especially in patients receiving cyclosporin A (CsA) medication with no concomitant nifedipine. In this respect, nifedipine and CsA are different.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Nurmenniemi PK,Pernu HE,Knuuttila MLdoi
10.1902/jop.2004.75.7.933subject
Has Abstractpub_date
2004-07-01 00:00:00pages
933-8issue
7eissn
0022-3492issn
1943-3670journal_volume
75pub_type
杂志文章abstract::Cystatins are physiological inhibitors of cysteine proteinases and widely distributed in human tissues and fluids including saliva. Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids. Previous studies demonstrated that total...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.3.205
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Implant failures are rare but do occur. Mechanical factors are certainly important in implant failures; so are biologic, iatrogenic, and functional factors. Mobility is the cardinal sign of implant failure. Three major etiologic factors have been suggested for implant failures: infection, impaired healing, a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.385
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs. METHODS:In eight beagle dogs, a critical-size...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120380
更新日期:2013-08-01 00:00:00
abstract::Despite the improvement in the patients' oral hygiene, there was no significant decrease in the frequency of bacteremia. There was no significant difference in bacteremia between brushing, flossing, or deplaquing either before or after initial periodontal preparation and plaque control in 21 healthy subjects. Utilizin...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.12.683
更新日期:1976-12-01 00:00:00
abstract::T-cell subsets extracted from chronically inflamed periodontal tissues were identified using monoclonal antibodies, and their functional activity was analysed using the autologous mixed lymphocyte reaction (AMLR). Tissue was obtained from a total of 33 adult periodontitis (AP) patients and 6 normal/marginal gingivitis...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.8.569
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Although there are several studies that show the prevalence and diameter of accessory root canals in the furcation area, there is a scarceness of studies that observe the trajectory and different types of cavo-interradicular canals. The aim of this study was to verify the prevalence of the different morpholo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060112
更新日期:2006-10-01 00:00:00
abstract::This investigation was undertaken to compare the Gindex saliva test scores with the Gingival Index scores and crevicular fluid flow scores, as proposed by Löe and Holm-Pedersen. Eighty-one patients were tested using the Gindex chemical analysis kit. Crevicular fluid was collected from the six teeth advocated by Ramfjo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.11.564
更新日期:1978-11-01 00:00:00
abstract::Ten mouse monoclonal antibodies were prepared against cultured bovine periodontal ligament cells to be used as reagents for the study of periodontal disease and wound healing. Using standard immunohistochemical methods, these antibodies were found to recognize cell surface antigens in formalin-fixed bovine periodontiu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.3.190
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the e...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090379
更新日期:2010-02-01 00:00:00
abstract::The purpose of this study was to conduct a direct comparison of two dose regimens of minocycline to determine 1) whether they achieved crevicular fluid concentrations in a therapeutic range; and 2) the frequency of side effects. In a double-blind design, 30 patients divided into 2 groups were given either 100 mg minoc...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1992.63.1.13
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:A specific labeler of the human gingival fibroblast (HGF) does not exist. Anionic maghemite nanoparticles allow labeling of a wide cell variety and their recognition in cellular, organotypical, and animal models. METHODS:We studied internalization effects of nanoparticles on an HGF phenotype in vitro, evalu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050064
更新日期:2006-02-01 00:00:00
abstract::Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermo...
journal_title:Journal of periodontology
pub_type: 社论
doi:10.1002/JPER.18-0553
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Cyclosporin A (CsA) induces gingival overgrowth (GO) in patients who seem to be prone to this disorder. It is still impossible to determine which patients will develop GO. Patients treated with the new immunosuppressive drug tacrolimus seem not to have GO. The aims of this study were to investigate transform...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050086
更新日期:2006-05-01 00:00:00
abstract::The form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis (JP). The disease has been the object of intense study because from its analysis may come insights into understanding other, more common, forms of periodontitis. We recently had th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.10.602
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication-related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (μCT) imag...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0547
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Crohn's disease is a chronic inflammatory bowel disease characterized by uncertainty in etiology and pathogenesis occasionally with manifestations in oral mucous membranes. This report reviews the literature on Crohn's disease and presents a patient with Crohn's disease on continuous anti-inflammatory and im...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.4.537
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:A 22-year-old African American female was referred for augmentation of keratinized gingiva around implants at the right and left maxillary second premolar sites. Presurgical evaluation revealed generalized melanosis of the buccal gingiva and a lack of keratinized tissue around implants at sites #4 and #13. N...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090289
更新日期:2010-01-01 00:00:00
abstract::This short report offers solutions for three common clinical problems. Based on their experience, the authors suggest using a "spoon" type partial denture for the temporary replacement of maxillary anterior teeth. The denture is unique in that it has no clasps and does not contact the marginal gingiva. Also, conventio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.6.341
更新日期:1984-06-01 00:00:00
abstract::This study compared demineralized-unicortical-ilium-strips (DUIS) and an expanded polytetrafluoroethylene (ePTFE) physical barrier in combination with decalcified freeze-dried bone allograft (DFDBA) for treatment of Class II mandibular furcations. Twenty patients with adult periodontitis and at least 2 furcation invas...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.8.803
更新日期:1996-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2002.73.3.317
更新日期:2002-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1993.64.8s.807
更新日期:1993-08-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2014.130693
更新日期:2014-10-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.11.1361
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:It was hypothesized that periodontal diseases may increase the risk of preeclampsia. To test this hypothesis, this study was conducted to determine the association between periodontal parameters and preeclampsia among women in the north of Jordan. METHODS:A case-control study was conducted among women who g...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050463
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Controversy over the long-term clinical effectiveness of hydroxyapatite (HA)-coated dental implants still persists, despite numerous clinical studies documenting high survival rates. Concerns about the degradation of the coating over the years have been raised; it has been speculated that resorption of the H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060271
更新日期:2007-05-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070309
更新日期:2008-03-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.5.457
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Earlier publications from our laboratory described the use of guided bone regeneration to fill large bone voids in the mandible created through en bloc resection in primates. The present report describes placement of implants into the regenerated bone with subsequent prostheses construction and loading. MET...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.6.703
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Gingival augmentation procedures are indicated primarily to increase an insufficient amount of gingiva and sometimes to halt the progression of gingival recession. The aim of this retrospective long-term study was to evaluate changes in the amount of keratinized tissue (KT) and in the position of the gingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070414
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:The clinical success of root coverage with autogenous connective tissue (CT) or acellular dermal matrix (ADM) has been well documented. However, limited histological results of CT grafts have been reported, and a case report of a human block section has been published documenting an ADM graft. The purpose of...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.2.178
更新日期:2005-02-01 00:00:00