Clinical, laboratory, and immunological studies of a family with a high prevalence of generalized prepubertal and juvenile periodontitis.


:A study of a consanguineous family with a high prevalence of localized juvenile periodontitis (LJP) and generalized prepubertal periodontitis (GPP) was done over a 7-and-a-half year period. The parents had adult periodontitis, while 2 daughters, aged 13 and 15, had LJP. Furthermore, 2 other daughters, ages 14 and 10, and a son, aged 9, were affected by GPP. Two remaining siblings were not affected. Clinical and radiographic examinations on all family members were done, and chemotaxis for blood neutrophils was assessed. Laboratory tests, immunological examinations, and evaluation for neutrophil functions were done on the GPP patients. Microbiological cultures were performed on 2 of the GPP patients, as well as in the mother. The mother, the 2 LJP patients, and 1 of the unaffected siblings had depressed PMN chemotaxis. The other family members, including the 3 GPP patients, had normal PMN chemotaxis. GPP patients did not have any systemic disease, and evidence of major defects in the immunological functions was not detected. LJP patients were successfully treated with root planing, subgingival curettage, and tetracycline therapy. Intensive periodontal therapy, combined with systemic administration of antibiotics, was not effective in halting periodontal tissue destruction in the 3 GPP patients. Results indicate that the underlying cause of GPP is not always related to leukocyte dysfunction. Since Actinobacillus actinomycetemcomitans was the most frequent pathogen found in subgingival microflora of 2 of the GPP patients, it is assumed that it may play a key role in the etiology of GPP.


J Periodontol


López NJ




Has Abstract


1992-05-01 00:00:00












  • Periodontitis as a manifestation of chronic benign neutropenia.

    abstract:BACKGROUND:A subcategory of chronic neutropenia is chronic benign neutropenia, which is characterized by a prolonged non-cyclic neutropenia as the sole abnormality, with no underlying disease to which the neutropenia can be attributed. Chronic neutropenia is defined as a low absolute neutrophil count for >6 months. In ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Zaromb A,Chamberlain D,Schoor R,Almas K,Blei F

    更新日期:2006-11-01 00:00:00

  • Assessment of risk for periodontal disease. I. Risk indicators for attachment loss.

    abstract::Specific risk indicators associated with either susceptibility or resistance to severe forms of periodontal disease were evaluated in a cross-section of 1,426 subjects, 25 to 74 years of age, mostly metropolitan dwellers, residing in Erie County, New York, and surrounding areas. The study sample exhibited a wide range...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Grossi SG,Zambon JJ,Ho AW,Koch G,Dunford RG,Machtei EE,Norderyd OM,Genco RJ

    更新日期:1994-03-01 00:00:00

  • Hepatitis. A review of the disease and its significance to dentistry.

    abstract::The report is a review of the literature related to hepatitis B and its implications for dental practitioners. Hepatitis B represents a serious health risk among dentists and simple preventive measures can greatly reduce the risk of transmission or contraction of the disease. Certain positive findings in a healthy his...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Withers JA

    更新日期:1980-03-01 00:00:00

  • Introduction of a mixture of β-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration.

    abstract:BACKGROUND:The purpose of this study is to evaluate whether β-tricalcium phosphate (β-TCP) could be a promising modality to help augment alveolar bone in periodontal tissue regeneration by bone marrow mesenchymal stem cells (BMMSCs). METHODS:Expanded BMMSCs and atelocollagen (Col) were mixed together (MSC/Col). A comb...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Nagahara T,Yoshimatsu S,Shiba H,Kawaguchi H,Takeda K,Iwata T,Mizuno N,Fujita T,Kurihara H

    更新日期:2015-03-01 00:00:00

  • The association between osteopenia and periodontal attachment loss in older women.

    abstract:BACKGROUND:Recent research suggests that osteopenia may be a predisposing factor for periodontal tissue destruction. If so, then a relationship should exist between measures of systemic bone mineral density and periodontal tissue destruction. The purpose of the present cross-sectional study was to evaluate the associat...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weyant RJ,Pearlstein ME,Churak AP,Forrest K,Famili P,Cauley JA

    更新日期:1999-09-01 00:00:00

  • A new hypothesis of periodontal homeostasis.

    abstract::A review of the experimental evidence evidence on marrow inhibition by implanted roots has shown that an inhibitory factor is present in all root surfaces. It is most marked in periodontally diseased roots and least in periodontally healthy roots. It is hypothesized that a "marked" amount would inhibit periodontal cel...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Morris ML

    更新日期:1980-01-01 00:00:00

  • The Adjunctive Effect of Platelet-Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel-Group Controlled Trial.

    abstract:BACKGROUND:Platelet-rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Keceli HG,Kamak G,Erdemir EO,Evginer MS,Dolgun A

    更新日期:2015-11-01 00:00:00

  • Modulation of Host PGE2 Secretion as a Determinant of Periodontal Disease Expression.

    abstract::An increasing body of evidence supports the concept that host-produced PGE2 mediates much of the tissue destruction that occurs in periodontal disease. PGE2 levels within the crevicular fluid can serve as a static assessment of ongoing disease activity; i.e., rate of attachment loss and bone resorption. New insights i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Offenbacher S,Heasman PA,Collins JG

    更新日期:1993-05-01 00:00:00

  • Clinical application of spiral tomography in anterior implant placement: case report.

    abstract:BACKGROUND:Placement of endosseous dental implants in edentulous areas of the anterior maxilla poses a unique challenge due to variations in the amount of residual alveolar bone. Implant position becomes crucial in cases demanding high esthetic results but possessing minimal ridge width or in cases requiring augmentati...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Dixon DR,Morgan R,Hollender LG,Roberts FA,O'Neal RB

    更新日期:2002-10-01 00:00:00

  • Dysregulation of miR-146a by periodontal pathogens: A risk for acute coronary syndrome.

    abstract:BACKGROUND:Periodontitis is a polymicrobial, chronic inflammatory disease leading to loss of tooth-supporting structures. The bacteremia, endotoxemia, and systemic low-grade inflammation associate periodontitis with systemic illnesses such as diabetes mellitus and coronary artery disease. Periodontal pathogens have bee...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Bagavad Gita J,George AV,Pavithra N,Chandrasekaran SC,Latchumanadhas K,Gnanamani A

    更新日期:2019-07-01 00:00:00

  • Epidermolysis bullosa acquisita: clinical manifestations, microscopic findings, and surgical periodontal therapy. A case report.

    abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Hakki SS,Celenligil-Nazliel H,Karaduman A,Usubütün A,Ertoy D,Ayhan A,Ruacan S

    更新日期:2001-04-01 00:00:00

  • Evaluation of periodontal probing forces.

    abstract::The purpose of this study was to evaluate interexaminer and intraexaminer probing force variations in various regions of the mouth and adjacent to different tooth surfaces. Fifty-eight dental clinicians composed of 13 periodontists, 15 general dentists, 15 hygienists and 15 senior dental students probed the facial sur...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Freed HK,Gapper RL,Kalkwarf KL

    更新日期:1983-08-01 00:00:00

  • Full- versus partial-mouth disinfection in the treatment of periodontal infections. Long-term clinical observations of a pilot study.

    abstract::A classical treatment for chronic adult periodontitis consists of four to six consecutive sessions of scaling and root planing at a 1- to 2-week interval. Such a so-called "quadrant or sextant therapy" might result in a reinfection of a previously disinfected area by bacteria from an untreated region. The purpose of t...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vandekerckhove BN,Bollen CM,Dekeyser C,Darius P,Quirynen M

    更新日期:1996-12-01 00:00:00

  • Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in pregnant women with chronic periodontitis.

    abstract:BACKGROUND:There is evidence of reduced antioxidant (AO) defense in periodontitis and pregnancy and adverse interactions between periodontitis and pregnancy. METHODS:In this study, serum and gingival crevicular fluid (GCF) total AO capacity (TAOC) and superoxide dismutase (SOD) enzyme concentrations in pregnant patien...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Akalin FA,Baltacioğlu E,Alver A,Karabulut E

    更新日期:2009-03-01 00:00:00

  • Clinical and Biochemical Evaluation of Lozenges Containing Lactobacillus reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Chronic Periodontitis.

    abstract:BACKGROUND:This study evaluates the effects on clinical and biochemical parameters of Lactobacillus reuteri-containing probiotic supplementation adjunctive to initial periodontal therapy in patients with chronic periodontitis (CP). METHODS:Thirty patients with CP were included and divided into two groups. Every patien...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: İnce G,Gürsoy H,İpçi ŞD,Cakar G,Emekli-Alturfan E,Yılmaz S

    更新日期:2015-06-01 00:00:00

  • Vascular endothelial growth factor in gingival tissues and crevicular fluids of diabetic and healthy periodontal patients.

    abstract:BACKGROUND:Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients ma...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Güneri P,Unlü F,Yeşilbek B,Bayraktar F,Kokuludağ A,Hekimgil M,Boyacioğlu H

    更新日期:2004-01-01 00:00:00

  • The potential use of gingival crevicular blood for measuring glucose to screen for diabetes: an examination based on characteristics of the blood collection site.

    abstract:BACKGROUND:This study examined conditions under which gingival crevicular blood (GCB) could be used to obtain a useful glucose reading to screen for undiagnosed diabetes during routine dental visits. METHODS:GCB and capillary finger-stick blood (CFB) glucose readings obtained with a glucometer were compared for 46 pat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Strauss SM,Wheeler AJ,Russell SL,Brodsky A,Davidson RM,Gluzman R,Li L,Malo RG,Salis B,Schoor R,Tzvetkova K

    更新日期:2009-06-01 00:00:00

  • Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis.

    abstract:BACKGROUND:Porphyromonas gingivalis is a major pathogen and has a high detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by P. gingivalis, and these play an important role in the adherence of the bacteria to periodontal tissue and biofilm formation. The aim of this study was to investigate...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Kan P,Sasaki H,Inaba K,Watanabe K,Hamada N,Minabe M

    更新日期:2019-08-01 00:00:00

  • The presence of bacteria in the oral epithelium in periodontal disease. II. Immunohistochemical identification of bacteria.

    abstract::Serial histological sections of gingiva obtained from each of six advanced adult periodontitis, two localized juvenile periodontitis and two periodontally healthy patients were used for specific identification of bacteria within the oral epithelium and adjacent connective tissue. Healthy gingival biopsies served as co...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Saglie FR,Smith CT,Newman MG,Carranza FA Jr,Pertuiset JH,Cheng L,Auil E,Nisengard RJ

    更新日期:1986-08-01 00:00:00

  • The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

    abstract::A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximate...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章


    authors: Vogel RI,Lamster IB,Wechsler SA,Macedo B,Hartley LJ,Macedo JA

    更新日期:1986-08-01 00:00:00

  • Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial.

    abstract:BACKGROUND:Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinica...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Zhou QB,Xia WH,Ren J,Yu BB,Tong XZ,Chen YB,Chen S,Feng L,Dai J,Tao J,Yang JY

    更新日期:2017-08-01 00:00:00

  • A method for determining patient oral care skills: The University of Mississippi Oral Hygiene Index.

    abstract::The plaque control record (O'Leary index) appears to be a commonly used oral hygiene index for assessing oral health skills. This index provides sufficient information for patient education; however, the time involved in data collection reduces its value. Most other indices limit the number of teeth and surfaces and f...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Silberman SL,Le Jeune RC,Serio FG,Devidas M,Davidson L,Vernon K

    更新日期:1998-10-01 00:00:00

  • Spontaneous pigmentation of non-pigmented palatal tissue after periodontal surgery.

    abstract:BACKGROUND:A 22-year-old African American female was referred for augmentation of keratinized gingiva around implants at the right and left maxillary second premolar sites. Presurgical evaluation revealed generalized melanosis of the buccal gingiva and a lack of keratinized tissue around implants at sites #4 and #13. N...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Holtzclaw D,Toscano NJ,Tal H

    更新日期:2010-01-01 00:00:00

  • Optimizing autologous bone contribution to implant osseointegration.

    abstract:BACKGROUND:Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional drills or bone scrapers. Additionally, we tested whether ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Coyac BR,Sun Q,Leahy B,Salvi G,Yuan X,Brunski JB,Helms JA

    更新日期:2020-12-01 00:00:00

  • Surgical crown lengthening: a 12-month clinical wound healing study.

    abstract:BACKGROUND:Surgical crown lengthening has been proposed as a means of facilitating restorative procedures and preventing periodontal injuries in teeth with structurally inadequate clinical crowns or exposing tooth structure in the presence of deep, subgingival pathologies which may hamper the access for proper restorat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Pontoriero R,Carnevale G

    更新日期:2001-07-01 00:00:00

  • Characterization of patients presenting for treatment to a university refractory periodontal diseases unit: three case reports.

    abstract:BACKGROUND:Of the many forms of periodontal disease, refractory periodontal diseases are the least characterized. They are defined as the continued degeneration of the periodontium despite adequate management. This has led to the suggestion that there may be a systemic component that is a contributing factor to the dev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Bhide VM,Tenenbaum HC,Goldberg MB

    更新日期:2006-02-01 00:00:00

  • Dose-dependent effects of platelet gel releasate on activities of human osteoblasts.

    abstract:BACKGROUND:Platelet-rich plasma is used in oral and maxillofacial surgery; however, its real efficacy is debated. Also, the in vitro effects on bone-specific functions are contradictory. Understanding the mechanisms of action of platelet-derived factors could be the basis for their proper use in clinical applications. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Uggeri J,Belletti S,Guizzardi S,Poli T,Cantarelli S,Scandroglio R,Gatti R

    更新日期:2007-10-01 00:00:00

  • Removal torque and histomorphometric evaluation of bioceramic grit-blasted/acid-etched and dual acid-etched implant surfaces: an experimental study in dogs.

    abstract:BACKGROUND:Surface modifications to dental implants have been used in an attempt to accelerate the osseointegration process. The objective of this study was to biomechanically/histomorphometrically evaluate a bioceramic grit-blasted and acid-etched surface (BGB/AA; test) versus a dual acid-etched implant surface (contr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Marin C,Granato R,Suzuki M,Gil JN,Piattelli A,Coelho PG

    更新日期:2008-10-01 00:00:00

  • Topographic classification of deformities of the alveolar process.

    abstract::A system of nomenclature for deformities of the alveolar process is presented. Descriptive, familiar topographic terms are used (crater, trench, moat, ramp and plane), and specific criteria are given for each term. Two hundred randomly selected osseous deformities in dry skulls were classified by two examiners at inde...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Karn KW,Shockett HP,Moffitt WC,Gray JL

    更新日期:1984-06-01 00:00:00

  • Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis.

    abstract::This report describes a case of rapidly progressive periodontal tissue breakdown and bone loss in an HIV-infected markedly immunosuppressed homosexual male. Within 6 months of initial presentation with a necrotizing ulcerative gingivitis, the lesion extended to a necrotizing ulcerative stomatitis involving the surroun...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Patton LL,McKaig R

    更新日期:1998-06-01 00:00:00