Abstract：
:T-cell subsets extracted from chronically inflamed periodontal tissues were identified using monoclonal antibodies, and their functional activity was analysed using the autologous mixed lymphocyte reaction (AMLR). Tissue was obtained from a total of 33 adult periodontitis (AP) patients and 6 normal/marginal gingivitis (N/MG) patients. All AP patients had received repeated oral hygiene instruction and root planing prior to the surgery, and the majority (30 out of 33) had at least one site with greater than 6 mm loss of attachment from the cementoenamel junction within the surgical field. The N/MG patients had no loss of attachment, and probing depths were less than 3 mm. Single cell suspensions were obtained following collagenase digestion (90 minutes at 37 degrees C) and mechanical disruption of the tissue. T-cell subsets were identified using an indirect immunofluorescence assay on cells obtained from 19 AP patients and the 6 N/MG patients. The mean (+/- standard error) helper:suppressor (T4:T8) ratio for the AP patients was found to be 0.94 +/- 0.48 compared with 1.65 +/- 0.16 for the N/MG group and 1.51 +/- 0.12 for peripheral blood controls. HLA-DR positive macrophages were identified and were found to include both acid phosphatase (AcP) positive and adenosine triphosphatase (ATPase) positive populations. Functional analysis was carried out using cells extracted from the remaining 14 AP patients. Cells from six of these 14 patients were found to be capable of spontaneous proliferation. Co-culture experiments using autologous T and non-T populations revealed that cells from only four patients were able to respond in an AMLR while those from only one of the 14 patients were able to stimulate the AMLR.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Cole KL,Seymour GJ,Powell RNdoi
10.1902/jop.1987.58.8.569subject
Has Abstractpub_date
1987-08-01 00:00:00pages
569-73issue
8eissn
0022-3492issn
1943-3670journal_volume
58pub_type
杂志文章abstract：BACKGROUND:During the last decade, there have been great strides in the treatment of gingival recession defects, especially with subepithelial connective tissue graft and guided tissue regeneration (GTR) procedures. Gingival recession represents a significant concern for patients. It is necessary to choose the most app...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.2000.72.9.1258
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:The efficacy of various partial-mouth recording (PMR) systems is analyzed in the evaluation of periodontal status, using index teeth and different combinations of quadrants. METHODS:The study group was formed of 108 adults aged 25 to 65 years old. A full-mouth examination (FME) was performed in all particip...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2013.130389
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients ma...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2004.75.1.91
更新日期：2004-01-01 00:00:00
abstract：:A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1982.53.3.163
更新日期：1982-03-01 00:00:00
abstract：:The relation between utilization of dental services from community dentists and the extent and severity of alveolar bone loss is reported for a panel of men followed for over 6 years. Oral health data were collected by the Department of Veterans Affairs, Dental Longitudinal Study, which began in 1969 and still continu...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1994.65.5s.551
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.2005.76.6.867
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Simvastatin has been shown to stimulate new bone growth on rat mandibles, but much of the bone is lost over time. The purpose of this study is to evaluate the impact of a locally or systemically applied antiresorptive agent (alendronate) on simvastatin-induced bone formation in and adjacent to a rat periodon...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2012.110683
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The goal of guided tissue regeneration-based root coverage (GTRC) is to repair gingival recession via new attachment formation. Numerous clinical trials have been conducted utilizing the concept of GTR to promote root coverage. Most GTRC studies have had relatively small sample sizes and have not utilized po...
journal_title：Journal of periodontology
pub_type： 杂志文章,meta分析,评审
doi：10.1902/jop.2003.74.10.1520
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Smoking is a major risk factor for periodontal disease. Conventional oral epidemiology approaches have found strong, consistent associations between chronic smoking and periodontal attachment loss (AL) through ages 26, 32, and 38 years, but those statistical methods disregarded the data's hierarchical struct...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2014.130577
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The rehabilitation of the oral cavity with dental implants has become a predictable treatment modality. However, there have been only a few direct comparisons evaluating the submerged and nonsubmerged placement techniques. The purpose of this study was to characterize radiographic peri-implant bone changes f...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1999.70.3.248
更新日期：1999-03-01 00:00:00
abstract：:The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-inci...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1997.68.12.1231
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2014.140386
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2012.120490
更新日期：2013-10-01 00:00:00
abstract：:Increasingly, patients referred to periodontists have undergone some form of non-surgical periodontal treatment prior to their referral. As a result of this, there is an increased need to treat isolated, rather than generalized, periodontal defects. A surgical technique that utilizes small incisions and a limited acce...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1999.70.12.1547
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:Various modifications of the laterally sliding flap have been proposed to reduce the risk of gingival recession at the donor tooth site, but the reported root coverage predictability was quite low. The goal of the present study was to evaluate the effectiveness with respect to root coverage of a modified sur...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2004.75.12.1734
更新日期：2004-12-01 00:00:00
abstract：:There are only a few long-term investigations on root-resected teeth in the literature. This article is a 10-year review of 28 root-resection cases, which mainly had been used as bridge abutments. The periodontal, prosthetic, and endodontic problems were evaluated. After 10 years a total failure rate of 32% was observ...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1988.59.12.805
更新日期：1988-12-01 00:00:00
abstract：:A retrospective study was conducted of 620 patients in a periodontal practice over the years 1960 to 1982. Various periodontal therapies were assessed by using careful office protocols, meticulous record-keeping and well-defined outcome criteria. Four treatment outcome categories were used: two representing satisfacto...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1985.56.5.253
更新日期：1985-05-01 00:00:00
abstract：BACKGROUND:Infection and inflammation induce epigenetic changes that alter gene expression. In periodontal disease, inflammation, and microbial dysbiosis occur, which can lead to compromised barrier function of the gingival epithelia. Here, we tested the hypotheses that infection of cultured human gingival epithelial (...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1002/JPER.20-0262
更新日期：2020-10-01 00:00:00
abstract：:Subtraction radiography requires radiographs made with identical projection geometry. Recently a new radiographic aiming device and an x-ray beam manipulator made it possible to repeat radiographic exposures in vivo with small angular errors and to measure the angular errors occurring. The purpose of the present inves...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1993.64.4.278
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:Desipramine is a tricyclic antidepressant with immune-modulatory activity, whose effects on ligature-induced periodontitis are yet to be investigated. Hence, its actions on alveolar bone resorption, gingival collagen content and key inflammatory mediators were herewith analyzed. METHODS:A total of 60 male W...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1002/JPER.19-0569
更新日期：2020-12-01 00:00:00
abstract：:Periodontal disease is a common infection-induced inflammatory disease among individuals suffering from diabetes mellitus. The purpose of this study was to assess the effects of treatment of periodontal disease on the level of metabolic control of diabetes. A total of 113 Native Americans (81 females and 32 males) suf...
journal_title：Journal of periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1902/jop.1997.68.8.713
更新日期：1997-08-01 00:00:00
abstract：BACKGROUND:Cannabis sativa (marijuana) can interfere with bone physiopathology because of its effect on osteoblast and osteoclast activity. However, its impact on periodontal tissues is still controversial. The present study evaluates whether marijuana smoke affects bone loss (BL) on ligature-induced periodontitis in r...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2011.100362
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:T cell cytokine profiles in the spleens and anti-Porphyromonas gingivalis antibodies in the sera of P. gingivalis-immunized BALB/c (H-2d), CBA/CaH (H-2k), C57BL6 (H-2b), and DBA/2J (H-2d, C5 deficient) mice were examined. METHODS:Mice were immunized either by intraperitoneal injections of P. gingivalis oute...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2000.71.7.1130
更新日期：2000-07-01 00:00:00
abstract：:In previous studies Fusobacterium nucleatum has been shown to induce either stimulatory or inhibitory effects on human mononuclear cells. We examined the interaction of human mononuclear cells with human and cynomolgus monkey strains of F. nucleatum. Peripheral blood mononuclear cells (PBMCs) isolated from normal dono...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1997.68.1.39
更新日期：1997-01-01 00:00:00
abstract：:Histologic sections from six autopsy cases which from a clinical point of view fitted into the criteria of periodontosis were examined with the aim at evaluating the role of subgingival plaque in the etiology of the loss of attachment in this condition. The following pertinent observations were made: 1. The subgingiva...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1976.47.11.636
更新日期：1976-11-01 00:00:00
abstract：BACKGROUND:Due to its concave morphology, a COL creates difficulties for proper oral hygiene. When this characteristic is accentuated by tooth position or caries and when restorations are necessary, they should be corrected by preprosthetic surgery. However, there are no data proving the efficacy of the procedures. The...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2001.72.12.1734
更新日期：2001-12-01 00:00:00
abstract：:Serial histological sections of gingiva obtained from each of six advanced adult periodontitis, two localized juvenile periodontitis and two periodontally healthy patients were used for specific identification of bacteria within the oral epithelium and adjacent connective tissue. Healthy gingival biopsies served as co...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.1986.57.8.492
更新日期：1986-08-01 00:00:00
abstract：BACKGROUND:Green tea is a very popular beverage, and in vitro studies have shown that green tea polyphenols inhibit the growth and cellular adherence of periodontal pathogens and their production of virulence factors. We investigated the epidemiologic relationship between the intake of green tea and periodontal disease...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2009.080510
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to perform alveolar ridge augmentation by distraction osteogenesis (DO) and to enhance bone regeneration through the use of recombinant human bone morphogenetic protein-2 (rhBMP-2), followed by implant placement. METHODS:Alveolar segmental osteotomy was performed in the mandibl...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2004.75.11.1524
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Hyperlipidemia is a known risk factor for cardiovascular diseases. A common biologic mechanism between systemic diseases, such as cardiovascular diseases, and periodontal diseases has been suggested. The aim of this study is to examine the association between blood lipid profile and periodontitis. METHODS:T...
journal_title：Journal of periodontology
pub_type： 杂志文章
doi：10.1902/jop.2017.170111
更新日期：2018-01-01 00:00:00
