Blood cell gene expression profiling in subjects with aggressive periodontitis and chronic arthritis.

Abstract:

BACKGROUND:Microarray analysis of local and peripheral cells in subjects with immune-inflammatory diseases may identify candidate genes associated with these diseases. The present study identified differentially expressed genes in peripheral blood mononuclear cells (PBMCs) from subjects with untreated localized aggressive periodontitis (LAgP) or generalized aggressive periodontitis (GAgP). Differentially expressed genes were validated in groups of subjects with LAgP, GAgP, juvenile idiopathic arthritis (JIA), or rheumatoid arthritis (RA) and controls. METHODS:Candidate genes were identified by gene expression profiling of PBMCs using a microarray system in untreated gender-matched subjects with LAgP (N = 2) or GAgP (N = 3) and controls (N = 2) younger than 35 years of age. The microarray results were validated by real-time reverse transcription-polymerase chain reaction (RT-PCR) using PBMCs from 103 individuals, including groups of subjects with LAgP (N = 18), GAgP (N = 27), JIA (N = 10), or RA (N = 23) and controls (N = 25). RESULTS:Of 53 differentially expressed candidate genes identified in subjects with LAgP, 14 were involved in immune responses and inflammatory processes. Of these, the RT-PCR validation confirmed that Toll-like receptor 2 gene (TLR2) and myomesin 2 gene had a significantly higher expression in subjects with LAgP than in controls. RT-PCR also showed increased expression of TLR2 in subjects with RA. Comparison of subjects with GAgP to controls using microarray analysis identified only three upregulated genes. CONCLUSION:Several genes upregulated in subjects with LAgP were related to immune responses including TLR2 and myomesin 2.

journal_name

J Periodontol

authors

Sørensen LK,Havemose-Poulsen A,Sønder SU,Bendtzen K,Holmstrup P

doi

10.1902/jop.2008.070309

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

477-85

issue

3

eissn

0022-3492

issn

1943-3670

journal_volume

79

pub_type

杂志文章
  • Periodontal manifestations of adult onset of histiocytosis X.

    abstract::Histiocytosis X, a reticuloendothelial disorder, includes the three clinical syndromes: Letterer-Siwe and Hand-Schuller-Christian diseases and eosinophilic granuloma of the bone. Twenty-eight cases of adult onset of histiocytosis X involving the head and neck region were found in the literature during the past 20 year...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1989.60.1.57

    authors: Artzi Z,Grosky M,Raviv M

    更新日期:1989-01-01 00:00:00

  • Underestimation of periodontitis in NHANES surveys.

    abstract::The study design of national surveys of periodontal disease often uses partial-mouth examination protocols to rationalize the need for resources so that the collection of data from a large number of subjects can be achieved within the available means without significantly sacrificing precision and validity. Studies sh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100638

    authors: Albandar JM

    更新日期:2011-03-01 00:00:00

  • Oral food consumption and subgingival microorganisms: subgingival microbiota of gastrostomy tube-fed children and healthy controls.

    abstract::This study examined the effect of oral food consumption on the prevalence and levels of subgingival bacteria and yeasts in 20 gastrostomy tube-fed children and 24 healthy controls. Microbial identification was carried out using anaerobic culture and 16S rRNA-based PCR identification methods. Streptococcal and Actinomy...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.12.1163

    authors: Chen C,Ashimoto A,Sangsurasak S,Flynn MJ,Slots J

    更新日期:1997-12-01 00:00:00

  • A radiographic evaluation of bone healing around submerged and non-submerged dental implants in beagle dogs.

    abstract:BACKGROUND:The rehabilitation of the oral cavity with dental implants has become a predictable treatment modality. However, there have been only a few direct comparisons evaluating the submerged and nonsubmerged placement techniques. The purpose of this study was to characterize radiographic peri-implant bone changes f...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.3.248

    authors: Fiorellini JP,Buser D,Paquette DW,Williams RC,Haghighi D,Weber HP

    更新日期:1999-03-01 00:00:00

  • Salivary and plasma levels of Toll-like receptor 2 and Toll-like receptor 4 in chronic periodontitis.

    abstract:BACKGROUND:This cross-sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll-like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy. METHODS:Whole saliva and plasma samples were obtained and full-mouth c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100467

    authors: Buduneli N,Özçaka Ö,Nalbantsoy A

    更新日期:2011-06-01 00:00:00

  • Topographic classification of deformities of the alveolar process.

    abstract::A system of nomenclature for deformities of the alveolar process is presented. Descriptive, familiar topographic terms are used (crater, trench, moat, ramp and plane), and specific criteria are given for each term. Two hundred randomly selected osseous deformities in dry skulls were classified by two examiners at inde...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.6.336

    authors: Karn KW,Shockett HP,Moffitt WC,Gray JL

    更新日期:1984-06-01 00:00:00

  • Relationships between periodontal disease and bacterial pneumonia.

    abstract::Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that bacterial pneumonia will assume increasing importance in the coming ye...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1996.67.10s.1114

    authors: Scannapieco FA,Mylotte JM

    更新日期:1996-10-01 00:00:00

  • Subgingival microflora of advanced periodontitis in the Dominican Republic.

    abstract::A study of the predominant subgingival microflora was carried out in 24 periodontitis patients, 18 to 60 years of age, in Santo Domingo, Dominican Republic. Paper point sampling, transport in VMGA III, and conventional microbiological techniques were utilized. Direct microscopic examination revealed that cocci and non...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.9.543

    authors: Slots J,Rams TE,Feik D,Taveras HD,Gillespie GM

    更新日期:1991-09-01 00:00:00

  • Improvement of multiple facial gingival recession by non-surgical and supportive periodontal therapy: a case report.

    abstract::We report a case of multiple facial gingival recession which was improved by non-surgical and supportive periodontal therapy. The patient, a 28-year-old Japanese woman, presented for treatment of multiple facial gingival recession ranging from 1 to 4 mm on teeth 5 through 12 and 19 through 30. Periodontal plastic surg...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.8.909

    authors: Ando K,Ito K,Murai S

    更新日期:1999-08-01 00:00:00

  • Clinical comparison of hydroxyapatite-coated titanium dental implants placed in fresh extraction sockets and healed sites.

    abstract::The placement of hydroxyapatite-coated dental implants in fresh extraction sockets was compared to placement in adjacent healed sites in 14 patients. Systematic sequential documentation was obtained regarding periodontal health, radiographic bone levels, and implant stability at the time of implant placement, at uncov...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.7.468

    authors: Yukna RA

    更新日期:1991-07-01 00:00:00

  • Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial.

    abstract:BACKGROUND:This study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcurrent electrotherapy on palatal wound healing. METHODS:This was a parallel, double-masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly ass...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0122

    authors: Miguel MMV,Mathias-Santamaria IF,Rossato A,Ferraz LFF,Figueiredo-Neto AM,de Marco AC,Casarin RCV,Wallet SM,Tatakis DN,Mathias MA,Santamaria MP

    更新日期:2020-08-12 00:00:00

  • Phenytoin-induced gingival overgrowth resulting in delayed eruption of the primary dentition. A case report.

    abstract::A case of delayed eruption of the primary dentition secondary to phenytoin therapy in a 4-year-old child is reported. The patient had been on phenytoin therapy since the first months of life. Radiographs revealed that alveolar but not gingival emergence had occurred. Surgical excision of the excess gingival tissue was...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1984.55.1.19

    authors: Church LF Jr,Brandt SK

    更新日期:1984-01-01 00:00:00

  • Reexamining the association between smoking and periodontitis in the dunedin study with an enhanced analytical approach.

    abstract:BACKGROUND:Smoking is a major risk factor for periodontal disease. Conventional oral epidemiology approaches have found strong, consistent associations between chronic smoking and periodontal attachment loss (AL) through ages 26, 32, and 38 years, but those statistical methods disregarded the data's hierarchical struct...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.130577

    authors: Zeng J,Williams SM,Fletcher DJ,Cameron CM,Broadbent JM,Shearer DM,Thomson WM

    更新日期:2014-10-01 00:00:00

  • Influence of plaque control on the healing of experimentally-induced bone defects in the dog.

    abstract::The aim of this investigation was to induce alveolar bone defects experimentally in dogs and to study the effects of mechanical tooth cleaning on their subsequent development. Thirty premolars from four beagle dogs were used. Bone defects were created by surgically exposing the adjacent alveolar bone and applying stee...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.3.135

    authors: Hugoson A,Schmidt G

    更新日期:1978-03-01 00:00:00

  • Vascular endothelial growth factor in gingival tissues and crevicular fluids of diabetic and healthy periodontal patients.

    abstract:BACKGROUND:Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients ma...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2004.75.1.91

    authors: Güneri P,Unlü F,Yeşilbek B,Bayraktar F,Kokuludağ A,Hekimgil M,Boyacioğlu H

    更新日期:2004-01-01 00:00:00

  • Clinical and laboratory studies of a family with a high prevalence of juvenile periodontitis.

    abstract::The form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis (JP). The disease has been the object of intense study because from its analysis may come insights into understanding other, more common, forms of periodontitis. We recently had th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.10.602

    authors: Page RC,Vandesteen GE,Ebersole JL,Williams BL,Dixon IL,Altman LC

    更新日期:1985-10-01 00:00:00

  • Effective periodontal treatment in a patient with type IIA von Willebrand's disease: report of a case.

    abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.5.548

    authors: Izumi Y,Taniguchi T,Maruyama Y,Sueda T

    更新日期:1999-05-01 00:00:00

  • A retrospective cohort study on peri-implant complications in implants up to 10 years of functional loading in periodontally compromised patients.

    abstract:BACKGROUND:Prevalence of peri-implantitis is directly proportional to the time of functional loading. The aim of this retrospective study was to assess the survival and success rates as well as the incidence of peri-implantitis among patients with a history of periodontitis and among implants with 1 to 10 years of func...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.18-0715

    authors: Pandolfi A,Rinaldo F,Pasqualotto D,Sorrentino F,La Torre G,Guerra F

    更新日期:2019-12-20 00:00:00

  • Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study.

    abstract:BACKGROUND:The objective of this study is to characterize the association between metabolic syndrome (MetS) and periodontitis in women, for which there is limited evidence. METHODS:Cross-sectional associations between MetS and periodontitis were examined in 657 postmenopausal women aged 50 to 79 years enrolled in a pe...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2014.140185

    authors: LaMonte MJ,Williams AM,Genco RJ,Andrews CA,Hovey KM,Millen AE,Browne RW,Trevisan M,Wactawski-Wende J

    更新日期:2014-11-01 00:00:00

  • Evaluation of the immunogenicity of freeze-dried skin allografts in humans.

    abstract::A study was undertaken to evaluate the antigenic potential of allogeneic freeze-dried skin (FDS) when used as a grafting material and to examine the clinical results when FDS is used for the correction of mucogingival problems in humans. FDS was obtained from an HLA-tissue-type donor according to Navy Tissue Bank prot...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.10.571

    authors: Gher ME Jr,Williams JE Jr,Vernino AR,Strong DM,Pelleu GB Jr

    更新日期:1980-10-01 00:00:00

  • RANKL upregulation associated with periodontitis and Porphyromonas gingivalis.

    abstract:BACKGROUND:Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital roles in the progression of bone loss in periodontitis. In this study, the expression of RANKL and OPG mRNA and the relationshi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060398

    authors: Wara-aswapati N,Surarit R,Chayasadom A,Boch JA,Pitiphat W

    更新日期:2007-06-01 00:00:00

  • Vertical distance from the crest of bone to the height of the interproximal papilla between adjacent implants.

    abstract:BACKGROUND:As patient demand increases for more natural restorations in the esthetic zone, clinicians must have the highest level of skill and knowledge to maintain or reform the interdental papilla between teeth, between implants and teeth, and between adjacent implants. To date, there are no reports that have measure...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.12.1785

    authors: Tarnow D,Elian N,Fletcher P,Froum S,Magner A,Cho SC,Salama M,Salama H,Garber DA

    更新日期:2003-12-01 00:00:00

  • Risk Indicators for Periodontitis in US Adults: NHANES 2009 to 2012.

    abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160013

    authors: Eke PI,Wei L,Thornton-Evans GO,Borrell LN,Borgnakke WS,Dye B,Genco RJ

    更新日期:2016-10-01 00:00:00

  • The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis.

    abstract::The purpose of this study was to evaluate the safety and clinical efficacy of controlled-release tetracycline-containing fibers in patients with refractory periodontitis versus the preceding classical treatment. One hundred twenty-one sites in 20 patients were followed from baseline to 6 months after fiber insertion. ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1997.68.4.353

    authors: Vandekerckhove BN,Quirynen M,van Steenberghe D

    更新日期:1997-04-01 00:00:00

  • Effect of supragingival plaque control in smokers and never-smokers: 6-month evaluation of patients with periodontitis.

    abstract:BACKGROUND:The effect of supragingival plaque control on clinical signs of periodontitis is controversial, particularly when smoking habits are considered. This study evaluated the clinical effects of supragingival plaque control on clinical signs of periodontitis in smokers and never-smokers. METHODS:The following da...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2007.060462

    authors: Gomes SC,Piccinin FB,Susin C,Oppermann RV,Marcantonio RA

    更新日期:2007-08-01 00:00:00

  • Histologic comparison of healing following tooth extraction with ridge preservation using two different xenograft protocols.

    abstract:BACKGROUND:The objectives of this study are to compare differences in histologic and clinical healing following tooth extraction and ridge preservation using two different xenograft treatment protocols. METHODS:Forty-four patients with a non-molar tooth that required extraction and planned implant placement were rando...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.120219

    authors: Cook DC,Mealey BL

    更新日期:2013-05-01 00:00:00

  • Effect of section thickness on cone beam computed tomography-based measurements of intrabony defects compared with clinical measurements.

    abstract:BACKGROUND:It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0338

    authors: Nikolic-Jakoba N,Barac M,Jankovic S,Aleksic Z,Spin-Neto R,Wenzel A

    更新日期:2020-08-21 00:00:00

  • HTR polymer grafts in human periodontal osseous defects. I. 6-month clinical results.

    abstract::HTR polymer was evaluated as a grafting material in periodontal osseous defects in 21 adult patients. Following initial preparation and pre-surgical documentation with standardized measurements, radiographs, and photographs, vertical osseous defects were treated with surgical open flap debridement alone (DEBR) or with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.10.633

    authors: Yukna RA

    更新日期:1990-10-01 00:00:00

  • Laser irradiation of bone: III. Long-term healing following treatment by CO2 and Nd:YAG lasers.

    abstract:BACKGROUND:Relative few reports exist concerning healing of laser created osteotomies over an extended period of time. The purpose of this study was to evaluate long-term healing, from 21 to 63 days, of osteotomy defects in the rat tibia created with the Nd:YAG and CO2 in the presence of a surface cooling spray of air/...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.2.174

    authors: McDavid VG,Cobb CM,Rapley JW,Glaros AG,Spencer P

    更新日期:2001-02-01 00:00:00

  • An evaluation of laser Doppler readings obtained from human gingival sulci.

    abstract::A small laser doppler probe with an outside diameter comparable to a conventional periodontal probe (0.5 mm) was developed. The objectives of this investigation were to determine if intrasulcular laser doppler readings (LDR): 1) are reproducible; 2) can detect vascular changes associated with trauma from probe placeme...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1995.66.3.171

    authors: Hinrichs JE,LaBelle LL,Aeppli D

    更新日期:1995-03-01 00:00:00