[Immunosuppressive therapy for inflammatory bowel disease: consensus by the Austrian working group on IBD].

Abstract:

:Azathioprine (AZA) or 6-mercaptopurine (6-MP) are the immunosuppressive drugs of choice in the treatment of inflammatory bowel disorders (IBD). Optimal dosage for AZA is around 2.5 mg/kg body weight and induction of remission by these drugs may take 6 - 7 months. Intramuscularly applied Methotrexate (MTX) is the second choice, while its efficacy starts earlier than that of AZA; studies assessing oral low-dose MTX treatment are lacking. Cyclosporin is the standard treatment in case of steroid-refractory severe ulcerative colitis. This drug may also be used in patients with severe extraintestinal manifestations of IBD. Regarding other immunosuppressive drugs such as mycophenolic acid or 6-thioguanine respective controlled clinical study data are not available. The risk of malignancy using immunosuppressive drugs such as AZA is low and furthermore, especially AZA and 6-MP can be used rather safely during pregnancy.

journal_name

Z Gastroenterol

authors

Reinisch W,Dejaco C,Knoflach P,Petritsch W,Vogelsang H,Tilg H

doi

10.1055/s-2004-813500

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

1033-45; discussion 1046-7

issue

9

eissn

0044-2771

issn

1439-7803

journal_volume

42

pub_type

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