Malabsorption with progressive weight loss and multiple intestinal ulcers in a patient with T-cell lymphoma.

Abstract:

:We describe a 52-year-old woman who presented with severe diarrhea, nausea, intermittent abdominal pain and weight loss of 18 kg within ten months. Jejunal and duodenal ulcers were detected by endoscopy and multiple biopsies revealed villous atrophy of the jejunum. However, neither gliadin nor endomysium antibodies were detected and no clinical and histological improvement was achieved after gluten withdrawal. Despite strong clinical suspicion for intestinal lymphoma many unrevealing biopsies were done. The patient developed intermittent septic fever and diagnostic laparotomy revealed jejunal perforation. Partial jejunal resection was performed and histology confirmed the diagnosis of an intestinal T-cell lymphoma without celiac disease. Malabsorption and all intestinal ulcers disappeared during the course of chemotherapy (six cycles CHOP) and the patient recovered remarkably.

journal_name

Z Gastroenterol

authors

Widjaja A,Wagner S,Mix H,Rifai K,Rambusch E,Stolte M,Meier PN,Nashan B,Reimann J,Böker K,Heil G,Manns MP

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

611-4

issue

7

eissn

0044-2771

issn

1439-7803

journal_volume

37

pub_type

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