Abstract:
STUDY OBJECTIVE:To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol. DESIGN:Prospective, controlled, single-blind, partially randomized study. SETTING:Large medical center. PATIENTS:ASA physical status I-III patients undergoing elective surgical procedures of at least 3 hours' duration. INTERVENTIONS:The effect of pretreatment with nondepolarizing muscle relaxants (atracurium 40 micrograms/kg or metocurine 50 micrograms/kg), benzodiazepine agonists (diazepam 5 mg or midazolam 2.5 mg), or thiopental sodium 1 mg/kg on the increased muscle tone produced by alfentanil 175 micrograms/kg was compared with a control group (given no pretreatment). MEASUREMENTS AND MAIN RESULTS:Rigidity was assessed quantitatively by measuring the electromyographic activity of five muscle groups (biceps, intercostals, abdominals, quadriceps, and gastrocnemius). Rigidity also was rated qualitatively by attempts to initiate and maintain mask ventilation, attempts to flex an extremity, and the occurrence of myoclonic movements. Pretreatment with the two nondepolarizing muscle relaxants had no effect on the severe muscle rigidity produced by high-dose alfentanil. Whereas thiopental was only mildly effective, the benzodiazepines midazolam and diazepam significantly attenuated alfentanil rigidity (p < 0.05). CONCLUSION:This study suggests that benzodiazepine pretreatment is frequently, but not always, effective in preventing opioid-induced muscle rigidity.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Sanford TJ Jr,Weinger MB,Smith NT,Benthuysen JL,Head N,Silver H,Blasco TAdoi
10.1016/0952-8180(94)90087-6subject
Has Abstractpub_date
1994-11-01 00:00:00pages
473-80issue
6eissn
0952-8180issn
1873-4529pii
0952-8180(94)90087-6journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract::The use of direct oral anticoagulants including apixaban, rivaroxaban, and dabigatran, which are approved for several therapeutic indications, can simplify perioperative and postoperative management of anticoagulation. Utilization of regional neuraxial anesthesia in patients receiving anticoagulants carries a relative...
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