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Comparison of propofol with thiopental and isoflurane for induction and maintenance of general anesthesia.

Abstract：

:Propofol, a phenol compound with a short elimination half-life, was compared with thiopental and isoflurane for induction and maintenance of general anesthesia in 60 consenting ASA I, II, and III patients. The study was randomized and open label in design. Hemodynamically, the propofol patients showed a mean +/- SEM decrease in systolic blood pressure in comparison with the thiopental/isoflurane group at 2 (115.1 +/- 4.9 vs. 136.6 +/- 6.0 mmHg), 3 (125.7 +/- 5.1 vs. 149.4 +/- 5.6 mmHg), and 5 min (126.6 +/- 3.8 vs. 144.4 +/- 6.1 mmHg) postinduction and at intubation (135.2 +/- 4.7 vs. 157.8 +/- 6.0 mmHg) (p less than 0.05). The heart rate was lower in the propofol group throughout the induction period (p less than 0.05). Patients who received propofol were ready for discharge from the recovery room sooner (67.9 +/- 4.0 vs. 80.0 +/- 3.6 min) than the thiopental/isoflurane-treated patients (p less than 0.05). Propofol is as safe and effective for induction and maintenance of general anesthesia as thiopental and isoflurane.

journal_name

J Clin Anesth

journal_title

Journal of clinical anesthesia

authors

Gold MI,Sacks DJ,Grosnoff DB,Herrington CA

doi

10.1016/0952-8180(89)90026-3

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

272-6

issue

4

eissn

0952-8180

issn

1873-4529

pii

0952-8180(89)90026-3

journal_volume

1

pub_type

临床试验,杂志文章,随机对照试验

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